Neurological and Immune Reactive Conditions Affecting Kids: The mercury connection to neurological pervasive developmental disorders ( autism, schizophrenia, dyslexia, ADD, childhood depression, learning disabilities, OCD ) and developmental immune conditions ( eczema, asthma, and allergies )- Bernard Windham (Ed) DAMS Intl
The incidence of neurotoxic, allergic, and immune reactive conditions such as autism, schizophrenia, ADD, dyslexia, allergies, asthma, eczema, psoriasis, childhood diabetes, etc. have been increasing rapidly in recent years (1,2,3,5,23,50,52,59,75,82,86,92,142). A report by the National Research Council in 2000 found that 50% of all pregnancies in the U.S. were resulting in prenatal or postnatal mortality, significant birth defects, developmental disabilities or otherwise chronically unhealthy babies (3a) and studies published in JAMA found similar trends continuing with huge increases in childhood chronic conditions (3de). Incidence of chronic developmental conditions in infants more than doubled between 1988 and 2006, especially asthma, learning and behavioral problems, and obesity (3e). There has been a similar sharp increase in developmental disabilities in Canadian children over the last 2 decades (71), including learning disabilities and behavioral problems, asthma and allergies, and childhood cancer. Studies have documented that the primary cause of the increased developmental conditions are increased toxic exposures, including increased use of vaccines with toxic and inflammatory ingredients (50, etc.).
The U.S. Dept. Of Education indicates that over 5 million children attending school have neurological related disabilities reported by state agencies, other than ADD(2a). A random sample of Oregon high school students found that over 16% had been diagnosed with depression(75b). According to the American Academy of Pediatrics between 6 to 12 % of all school age children are affected by ADHD (4) and a similar number have some degree of dyslexia (1). "The Centers for Disease Control issued a new survey report that showed 5.4 million schoolchildren have been diagnosed with attention-deficit/hyperactivity disorder (AD/HD). That was 10%." In fact, "from the years 2003 to 2007, the number of kids between four and 17 with AD/HD jumped by one million. That's a 22% increase."(560) However large surveys of elementary level student records find much higher levels- with over 20% of elementary school boys in some areas being treated for ADD (75a, 560). Studies have found that long term use of stimulant drugs commonly causes significant adverse neurological and health effects (76), and options are available to deal with such conditions without such adverse effects including dealing with the underlying causes. Estimates of the percentage of children with mood or anxiety orders are as much as 20%.
The health effects of toxic metals are synergistic with other toxic exposures such as pesticides , herbicides,& other endocrine disrupting substances like organochlorine compounds , POP s, PAHs , PCBs, etc. There are also synergistic effects with the various types of parasites, bacteria, viruses to which people have common exposures and commonly become infected when the immune system is weakened by toxic exposures. Studies have found considerable genetic variability in susceptibility to toxic metals as well. The health effects caused to children by pesticides and herbicides include birth defects, ADHD, seizures, developmental conditions, etc. While there is considerable commonality to the health effects commonly caused by the toxic metals, and effects are cumulative and synergistic with other toxic exposures, this paper will concentrate on the health effects of elemental mercury from amalgam fillings and toxic metals.
Most of the increase in children’s neurological or developmental conditions have been found to be related to major increases in brain and immune system inflammation related to increased exposure to toxic chemicals or dietary excitoxins of the 4 million U.S. children born each year (598,3,1,2,22,33). At least 1 in 6 had one of the neurological conditions previously listed (1-3). One of the main causes of increased exposures to toxic metals such as mercury and aluminum and other toxics is the greatly increased vaccination schedule for infants in recent years compared to 1983 and prior (4e). Another major source of mercury exposure is dental amalgam fillings (500,501,576). U.S. EPA has estimated that over 3 million of these are related to lead or mercury toxicity, with at least 25% of U.S. children getting mercury exposure at dangerous levels (1,81,499-502). The National Center for Education Statistics reported that between 1990-2005 the number of children receiving special education services (SES) rose significantly, and then, from 2004-2012, the number declined significantly. This coincided with the introduction of Thimerosal-containing hepatitis B vaccine in 1991, and the subsequent introduction of Thimerosal-reduced hepatitis B vaccine in the early 2000s(12d,142).
Researchers have found that the most striking differences between autistic and normal brains were loss of the purkinje cell layer in the cerebellum, and also activation of the microglia, which are cells that are central to the inflammatory response. The inflammatory response is your body's defense against invasion, but in autism, it seems there is an inflammatory war going on in the brains of autistic children and adults (595). According to Psychology Today: "Other studies have shown that autism is possibly an autoimmune disease of some kind ... the immune system is not only fighting external invaders or bad guys in the body, such as viruses, bacteria, or newly-formed cancer cells, but also has started to attack presumably healthy tissues of the body. In the evolutionary medicine paradigm, autoimmune disorders are diseases of civilization, caused by our highly inflammatory diets and stressful lifestyles." (595a)
Studies indicate that over 60,000 children are born each year with neurodevelopmental impairments due to prenatal exposure to methyl mercury (45,46). But two other sources of mercury exposure appear to have been more common and at higher levels than this, ethyl mercury from vaccines (23,33) and mercury vapor from amalgam dental fillings (81,501,13), with Mom � s mercury fillings being a the largest source of mercury in the fetus and a significant source of mercury in infants(502,580). Vaccines have unacceptable levels of many toxics such as mercury thimerosal, aluminum, formaldehyde, endotoxins, and altered strains of viruses that cause brain i nflammation and immune effects on infants (158,580,582,598,52,570,571,572,575,35), with some more susceptible to such effects than others based on genetics and other synergistic toxic exposures .
Another study has found results suggesting that EMR radiation such as cell phones and cell phone towers may be another significant factor in autism (583). The study found a significant correlation between measured heavy metal concentrations, exposure to EMR, and autism.
II. Autism spectrum disorder (ASD), tic disorder (TD), and hyperkinetic syndrome of childhood (attention deficit disorder [ADD]/attention deficit hyperactivity disorder [ADHD]) are disorders recently defined as abnormal connectivity spectrum disorders (ACSDs) because they show a similar pattern of abnormal brain connectivity. A large study (80a) examined whether these disorders are associated with exposure to thimerosal, a mercury (Hg)-based preservative. On a per 25 μg Hg basis, cases diagnosed with ASD (OR = 1.493), TD (OR = 1.428), or ADD/ADHD (OR = 1.503) were significantly ( P < .001) more likely than controls to have received increased Hg exposure. Similar relationships were observed when separated by gender. Cases diagnosed with control outcomes were no more likely than controls to have received increased Hg exposure.
Another similar study evaluated Thimerosal-containing childhood vaccines and the risk of a diagnosis called disturbance of emotions specific to childhood and adolescence (ED).(80b) Cases diagnosed with ED were significantly more likely than controls to have received increased Hg exposure within the first month of life (odds ratio (OR) = 1.3384), the first 2 months of life (OR = 1.3367) and the first 6 months of life (OR = 2.37). When the data were separated by gender, similar significant adverse effects were observed for males, but not females. On a per microgram Hg basis, cases diagnosed with ED were significantly more likely than controls to have received increased exposure within the first 6 months of life (OR = 1.025 per microgram Hg). Another study evaluated the hypothesis that the 1999 recommendation by the American Academy of Pediatrics (AAP) and US Public Health Service (PHS) to reduce exposure to mercury (Hg) from Thimerosal in US vaccines would be associated with a reduction in the long-term risk of being diagnosed with autism (80c). Analysis of the VAERS database using logistic regression revealed that the odds ratio (OR) for being an autism case in the VAERS database significantly decreased with a more recent year of vaccination in comparison to controls (OR=0.65) from 1998 to 2003. Sex-separated analyses revealed similar significant effects for males (OR=0.62) and females (OR=0.71). The study concluded that the risk of autism during from the late1990s to early 2000s in the US significantly decreased with reductions in Hg exposure from Thimerosal-containing childhood vaccines, but future studies should examine this phenomenon in other US populations. Another case-control study evaluated automated medical records for exposure to organic-Hg from Thimerosal-containing hepatitis B vaccines (TM-HepB) administered at specific intervals in the first six-months-of-life among cases diagnosed with a tic disorder (TD) or cerebral degeneration (CD) (80d). TD cases were significantly more likely than controls to have received increased organic-Hg from TM-HepB administered within the first month-of-life (odds ratio (OR)=1.59, p<0.00001), first two-months-of-life (OR=1.59, p<0.00001), and first six-months-of-life (OR=2.97, p<0.00001). Male TD cases were significantly more likely than male controls to have received increased organic-Hg from TM-HepB administered within the first month-of-life (OR =1.65, p<0.0001), first two-months-of-life (OR=1.64, p<0.0001), and first six months-of-life (OR=2.47, p<0.05), whereas female TD were significantly more likely than female controls to have received increased organic-Hg from TM-HepB administered within the first six-months-of-life (OR=4.97, p<0.05). Similar large studies found similar results for autism and other neurological conditions (80efghij,81,88,91,140,170, etc.). �
A survey of thousands of parents of autistic children or children with Asperger � s by the Autism Association found that chelation/detoxification was by far the most effective treatment for autism and also much safer than most drug treatments for autism spectrum conditions (110,133,205). This is consistent with the findings of most autism treatment clinic tests that most autistic children tested are highly mercury and metal toxic (101,100,603). Another significant factor in some autism cases has been found to be lyme disease (98b).
A study at the U.S. CDC found "statistically significant associations" between neurologic developmental disorders such as autism, attention deficit disorder (ADD) and speech disorders with exposure to mercury from thimerosal containing vaccines before the age of 6 months (62,80). An analysis of the U.S. CDC VAERS database for adverse reactions from vaccines regarding effects of the diptheria-tetanus-pertusis vaccine found that those receiving DTaP and DTucP vaccines with thimerosal had significantly higher rates of autism, speech disorders, and heart arrest than those receiving DtaP vaccine without thimerosal, and that the rate of these increase exponentially with dose (81). The Head of the CDC has admitted that mercury can cause autism in susceptible children (130). An analysis of the U.S. Dept. of Education report on the prevalence of various childhood conditions among school children found that the rate of autism and speech disorders increased with increasing levels of thimerosal exposure from vaccines (81). Mercury has been well documented to cause birth defects, spontaneous abortions, and neurological problems (116,502,570), so these autism related effects are not surprising.
A follow-up study using DMSA as a chelator found that overall, urinary mercury concentrations were significantly higher in children with autistic spectrum disorders than in a matched control population, and that vaccinated cases showed significantly higher urinary mercury concentrations than vaccinated controls(81b). This is consistent with other studies that found that those who are poor excreters of mercury are more likely to accumulate mercury and have adverse health effects. Changes in birth procedures in hospitals such as immediate cord clamping has also been found to be a factor in the increase in neurological developmental problems (83). Children with autism had significantly (2.1-fold) higher levels of mercury in baby teeth (90) and blood (102), but similar levels of lead and similar levels of zinc. Baby teeth are a good measure of cumulative exposure to toxic metals during fetal development and early infancy (90). A study of environmental mercury levels in Texas school districts found a 61 percent increase in autism and a 43 percent increase in special education cases for every 1,000 pounds of mercury released into the environment(94a). A utism prevalence diminished by 2 percent for every 10 miles of distance from a mercury source. Another similar study found similar results and estimated economic costs due to disability or lower IQ (94b). Fossil fuel-burning power plants were the largest source of the widespread mercury pollution (94) but dental amalgam was the largest source in sewers and a significant source of environmental mercury in water bodies, fish, and a significant source of air emissions, since all people with amalgams continuously release mercury by breathing and in waste products into sewers that has air emissions (95).
Children with autism also had significantly higher usage of oral antibiotics during their first 12 months of life. Children exposed to high levels or mercury and/or toxic metals have been found to have weakened immune system and increased susceptibility to pathogens (500,563). Tylenol, antibiotics, and milk are documented to increase the effects of mercury (570,571, etc.).
A new survey released recently indicates a strong correlation between rates of neurological disorders, such as ADHD and autism, and childhood vaccinations. The survey found vaccinated boys were two and a half times (155%) more likely to have neurological disorders compared to their unvaccinated peers. Vaccinated boys were 224% more likely to have Attention Deficit Hyperactivity Disorder (ADHD), and 61% more likely to have autism (93). For older vaccinated boys in the 11-17 age bracket, the results were even more pronounced. Vaccinated boys were 158% more likely to have a neurological disorder, 317% more likely to have ADHD, and 112% more likely to have autism. Other studies have found similar results regarding a connection to vaccines and toxic metals (92,50,131,562). Studies have also found a significant link between food additives (food colorings and food preservatives) and ADHD (561).
Asthma is a chronic inflammatory disorder of the airways, characterized by wheezing, shortness of breath, chest tightness, mucus production, etc. At least 7.2% of the adult population has asthma and asthma in children has become much more prevalent. (186) Asthma is closely tied to immune system reactions of the humoral system, as controlled by cell signaling cytokines. Allergic antigens bind to immune mast cells and basophils, and when these come into contact with IgE antibody, a hypersensitivity response of the immune system occurs leading to inflammation and bronchoconstriction.
It has been suggested that infant and childhood vaccinations may be contributing to the increasing prevalence of asthma. [5b] The strongest evidence in support of a possible association between vaccination and asthma comes from a prospective study of a cohort of children born in 1977 in Christchurch, New Zealand. [5b] In that study there was no evidence of asthma after 5 to 10 years of follow-up among 23 children who received neither pertussis nor oral polio vaccine, whereas asthma developed in >20% of 1184 children who had been vaccinated. A study of 1934 patients followed from birth to age 12 in a general medical practice in the UK found an ~1.4-fold increased risk of asthma associated with whole cell pertussis vaccination. [ 5b] An association between pertussis vaccination and asthma was also reported in two cross-sectional surveys. [ 2b]
There are theoretical reasons to suspect a possible association of asthma with vaccination. One possible mechanism is that vaccines or their adjuvants may have direct IgE-potentiating effects. [5c] Another possibility is that vaccination may shift the immunologic balance toward a more allergenic response. [5d] It has also been suggested that vaccination may indirectly affect the tendency to develop allergies and perhaps asthma, by preventing diseases in childhood, such as measles, which may protect against developing allergic conditions later in life. [5e] In the case of pertussis the disease has been suggested to increase the occurrence of atopy and asthma, and it may be that the vaccine could have similar effects. [5f]
Also according to the U.S. FDA, at least 26 million have allergies, at least 17 million have asthma (1b), 15 million have systemic eczema (82), and childhood diabetes is increasing rapidly (52, etc.). Although Russian and U.S. studies from the 1980s found that thimerosal was highly toxic and recommended that its use as a medical preservative should be discontinued (70,79,88,141), its use was not discontinued. One study(60a) found 5 times higher rate of allergy among a group vaccinated with pertussis vaccine (DPT) as opposed to an unvaccinated group, and 3 other studies(60bcd,141) found increased asthma, allergies, and eczema among the vaccinated group.
Vaccines given in the first 6 months of infants commonly cause asthma (99).
Over the last 20 years the percent of diabetes cases below 20 years old has increased from 2% to over 30%, and there was a 70% in cases under 40 years of age between 1990 and 1998(52,50). Studies in the U.S. and Sweden have confirmed vaccinations to be a major factor in the increased diabetes cases (52). Currently over 16 million have diabetes (52).
DPT vaccinations have also been linked to sudden infant death syndrome (SIDS)(61,92,141). DPT vaccines are mostly given at 2, 4, and 6 months of age and 85% of SIDS cases occur during this age span. One study found babies die at a rate 8 times the normal rate within 3 days of DPT shots(60a), while another found that among SIDS victims 61% had DPT within the 2 previous weeks and 13% within 24 hours of DPT vaccination (60c). According to Dr. Harris Coulter, "Crib death" was so infrequent in the pre-vaccination era that it was not even mentioned in the statistics, but it started to climb in the 1950s with the spread of mass vaccination against diseases of childhood." A monitoring study of infant breathing patterns after DPT vaccinations showed large increases in breathing difficulties including episodes of ceased breathing, which continued for months after DPT in some cases (61b). Infant deaths & SIDS clustered in the post vaccination period- 1 to 7 days post vaccination(study, (a)). SADS deaths and deaths to young healthy athletes from unexpected heart attacks were also found to cluster in similar post vaccination pattern. Medical evidence from autopsies found heart damage post-vaccination. (61h). Some cases of seizures after DPT were also observed. Another study found significantly higher rates of heart arrest in those getting DpaT vaccines with mercury thimerosal compared to those without (81). Prenatal exposure to mercury has also been found to predispose animals and infants to seizures and epilepsy (85).
Many thousands of adverse reactions and adverse health effects to the Gardasil HPV vaccine and many deaths (559).
The computer records from the National Vaccine Injury Compensation Program, obtained by Gannett News Service using the Freedom of Information Act as part of a four-month study of federal immunization policy, reveal: Of 253 infant death cases awarded more than $61 million by the U.S. Court of Federal Claims in the 1990s under the compensation program, 224, or 86 percent, were attributed to vaccination with DTP, the diphtheria, tetanus and pertussis (whooping cough) shot. In these cases, mortality was originally attributed to SIDS in 90, or 40 percent, of them. (61g) The Vaccine Court has awarded at least nine judgments in favor of children who have become autistic or have had serious damage from �� vaccine (137,581). The effect of metals in vaccines on peptides from milk and gluten have been suggested as another mechanism causing apnea in infants and some SIDS cases (24,26).
Andrew Wakefield has published about 130-140 peer-reviewed papers looking at the mechanism and cause of inflammatory bowel disease, and he has extensively investigated the brain-bowel connection in the context of children with developmental disorders such as autism. One of his studies(37a) has been highly criticized, but the criticisms have been documented to be for political reasons rather than science, and his study has been vindicated. A large number of replication studies have been performed around the world, by other researchers, confirming the curious link between brain disorders such as autism and gastrointestinal dysfunction. For a list of more than 25 of those studies, please see this previous article . "A team from the Wake Forest University School of Medicine in North Carolina are examining 275 children with regressive autism and bowel disease - and of the 82 tested so far, 70 prove positive for the measles virus. Last night the team's leader, Dr Stephen Walker, said: 'Of the handful of results we have in so far, all are vaccine strain and none are wild measles . 'This research proves that in the gastrointestinal tract of a number of children who have been diagnosed with regressive autism, there is evidence of measles virus. What it means is that the study done earlier by Dr Wakefield and published in 1998 is correct.
Of 771 total claims filed by parents from 1990 through mid-1998, 660, or 86 percent, contained assertions that DTP was the cause of death. And 43 percent were classified by medical authorities at time of death as SIDS cases.
A second federal database tends to draw a similar connection. This one, for the 1990s from the Food and Drug Administration, contains 460 reports of children who died within three days of receiving shots containing DTP. Of those 460 reports, 266 -- or 58 percent -- listed SIDS as a ``reaction.''
That database is called VAERS, for Vaccine Adverse Event Reporting System. It was ordered by Congress to track dangerous reactions to the shots all babies must receive as admission to our society. In typical federalese, the FDA refers to death as an � adverse event'' or a � reaction.'' By law, reports of reactions to DTP and other vaccines are supposed to be made religiously by doctors, pharmaceutical companies and public health clinics. But former FDA commissioner David A. Kessler has estimated the reports ``represent only a fraction of the serious adverse events'' -- perhaps as few as 10 percent. Dr. Marcel Salive, chief of the FDA's epidemiology staff, says, ``Any number you get, take with a grain of salt.'' (61g) Some spokespersons at various government and medical institutions have continued to deny the strong evidence that vaccines are a major factor in autism and other conditions, however they can identify no credible evidence to support their opinion that I � ve aware of. Most such have been found to have significant connections to special interests and no credible paper or clinical evidence has been provided to support their position that has not been credibly debunked in Congressional Hearings and other documentation (570,571,147,62,130,146, � etc.)
Vaccines contain immune adjuvants such as aluminum and mercury thimerosal that cause stimulation and activation of the immune system (598,580,582,570,571). Thimerosal and aluminum in vaccines have a synergistic effect of more than doubling the effect of one alone (158). � This has been found to cause high levels of brain inflammation with increased free radicals and inflammatory cytokines over prolonged periods of time, as long as a year from one vaccination. Brain inflammation has been found to be a major factor in irritability, anxiety, depression, insomnia, and neurological conditions including ADHD, schizophrenia, and autism(598,22a). Aluminum has also been found to significantly increase the effects of other toxics such as mercury through synergistic effects (582,571,158). Autistic children have been found to have on average 3 times as much aluminum in erythrocytes as non- autism children (571). There is new evidence supporting a link between the aluminum hydroxide used in vaccines, and symptoms associated with Parkinson's, amyotrophic lateral sclerosis (Lou Gehrig's disease), and Alzheimer's (582,571).
With large numbers of vaccines being given in recent years in rapid succession, the brain of infants becomes increasingly overexcited and inflamed, resulting in brain damage and disruption of brain development. Vaccine adjuvants, mercury from mother � s amalgam fillings (502), and dietary excitotoxins such as MSG and soy products have all been found to be major factors in the brain inflammation causing large numbers of developmental neurological conditions in children (158,598,580,582, etc.).
Mercury has been found to cause an increase in inflammatory Th2 cytokines (58,500,22). In the pancreas, the cells responsible for insulin production can be damaged or destroyed by the chronic high levels of cytokines, with the potential of inducing type II diabetes - even in otherwise healthy individuals with no other risk factors for diabetes(52). Mercury inhibits production of insulin and is a factor in diabetes and hypoglycemia, with significant reductions in insulin need after replacement of amalgam filings and normalizing of blood sugar(52,500). In addition to this mechanism, other links between vaccines and diabetes have also been found and there is evidence vaccines are the number one cause of Type I diabetes in young children (52).
The largest increase in neurological and immune conditions has been in infants (1,2,5-7,23,4,50,81,92,142), with an increase in autism cases to over 500,000 (1,2,23,86,142), an over 900% increase to a level of approx. 1 per 500 infants in the last decade(2ab), making it the 3rd most common chronic childhood condition. For 1999 through 2002, the number of professionally diagnosed in California with full syndrome autism had doubled(2e,86) and the trend continued. There were similar increases in ADD and dyslexia to over 10 million, similar large numbers (over 10%) with childhood depression or anxiety(75b), and over 10 % of infants- approximately 15 million in the U.S. with systemic eczema (1,2,82).
���� � Large numbers of studies researching the reason for these rapid increases in infant reactive conditions implicate earlier and higher usage of vaccines containing mercury(thimerosal) as the main connection (2cd,12,23,30,40,80-82,88,96,97,137,140-145,170). A recent study comparing pre and post vaccination mercury levels, found a significant increase in both preterm and term infants after vaccination(42a), with post vaccination mercury levels approximately 3 times higher in the preterm infants as compared with term infants. The study found mercury blood levels up to 23.6 ug/L and received an average dose of 16.7 ug/kg. Just this one vaccination gave an exposure to mercury that is many times the U.S. ATSDR adult minimum risk level (MRL) for mercury of .3/ug/kg body weight per day (41,81). �
����� Much research provides evidence that the use of hepatitis B vaccines with thimerosal in newborns is very harmful(12,42b,62). The first phase of a monkey study, published in 2009 in the journal Neurotoxicology , focused on the first two weeks of life. Baby monkeys received a single vaccine for Hepatitis B, mimicking the U.S. vaccine schedule, and were compared with matched, unvaccinated monkeys. The vaccinated monkeys, unlike their unvaccinated peers, suffered the loss of many reflexes that are critical for survival . A large study using longitudinal case-control design on prospectively collected data, in the Vaccine Safety Datalink (VSD). Cases diagnosed with premature pubert y were significantly more likely to have received increased exposure to Hg from hepatitis B vaccines preserved with Thimerosal given in the first month after birth (odds ratio (OR) = 1.803) and first six months after birth (OR = 2.0955), compared to control subjects(12a). A similar study found the same for Attention-deficit/hyperactivity disorder ( ADHD ) (12b). � Three doses of T-HepB exposure in comparison to no exposure significantly increased the risk of an ADHD diagnosis using logistic regression (adjusted odds ratio=1.980). Obesity among children and adolescents in the United States has tripled since 1980, and this has become a major public health concern(12d). A case-control study was undertaken to evaluate exposure to organic mercury from Thimerosal-containing hepatitis B vaccines, which were administered at specific intervals in the first 6 months of life, among cases diagnosed with childhood obesity and controls by examining automated medical records for children born from 1991 to 2000 who were continuously enrolled in the Vaccine Safety Datalink database. This study found highly significant associations as follows. Cases diagnosed with obesity were significantly (P < 0.00001) more likely to have received greater exposure to organic mercury from Thimerosal-containing hepatitis B vaccines administered within the first month of life (odds ratio (OR) =1.511), or first 6 months of life (OR = 3.795) than the controls. Similar outcomes were observed when the overall data were separated by gender. In a dose-response manner, cases diagnosed with obesity were significantly more likely than controls to have received greater exposure to organic mercury from Thimerosal-containing hepatitis B vaccines, which were administered within the first 6 months of life (OR = 1.0375 per μg of mercury, P < 0.00001). A similar study found similar results for atypical autism(12g). Cases diagnosed with atypical autism were statistically significantly more likely to have received greater overall and dose-dependent exposures to Hg from TM-HepB vaccines administered within the first month of life, first two months of life, and first six months of life than the controls. Similar phenomena were observed when cases and controls were separated by gender. A similar study found similar results for hyperkinetic syndrome of childhood (12e). Children diagnosed with HKSoC were significantly more likely to be exposed to increased organic-Hg from TM-HepB doses given within the first month (odds ratio = 1.45; 95% confidence interval (CI) = 1.30-1.62); or within the first six months (odds ratio = 4.51; 95% CI = 3.04-6.71) than controls. � CONCLUSION: The results indicate that increasing organic-Hg exposure from TCVs heightens the risk of a HKSoC diagnosis. Similar studies have found similar results for specific delays in development (12f). � Infants receiving increased Hg doses from T-HBVs administered within the first month, the first 2months, and the first 6months of life were significantly more likely to be diagnosed with specific delays in development than infants receiving no Hg doses from T-HBVs.
The National Center for Education Statistics reported that between 1990-2005 the number of children receiving special education services (SES) rose significantly, and then, from 2004-2012, the number declined significantly. This coincided with the introduction of Thimerosal-containing hepatitis B vaccine in 1991, and the subsequent introduction of Thimerosal-reduced hepatitis B vaccine in the early 2000s(12d,142). This study(12d) examined the potential relationship between infant exposure to mercury from three doses of Thimerosal-containing hepatitis B vaccine and the risk of boys being adversely affected (as measured by receipt of SES). This cross-sectional study examined 1192 boys (weighted n = 24,537,123) 7-8 years of age (born: 1994-2007) from the combined 2001-2014 National Health and Nutritional Examination Survey (NHANES). Survey logistic regression modeling revealed that an exposed population receiving three doses of infant Thimerosal-containing hepatitis B vaccine (weighted n = 11,186,579), in comparison to an unexposed population (weighted n = 704,254), were at an increased risk of receipt of SES. This association was robust (crude odds ratio = 10.143, p = 0.0232), even when considering covariates, such as race and socioeconomic status (adjusted odds ratio = 9.234, p = 0.0259). Survey frequency modeling revealed that receipt of SES for the population that was exposed to three doses of Thimerosal-containing hepatitis B vaccine in infancy (12.91%) was significantly higher than the unexposed population (1.44%) (prevalence ratio = 8.96, p = 0.006, prevalence attributable rate = 0.1147). It is estimated that an additional 1.2 million boys received SES with excess education costs of about United States (US) $180 billion associated with exposure to Thimerosal-containing hepatitis B vaccine(12d) .
���� The dozens of studies assessing the numbers affected for all of the conditions resulting estimate that the total medical costs of the damages seen likely exceed 1 trillion dollars. Since the danger of harm from vaccinations is generally accepted as being so large that no private insurance is available covering those giving vaccinations, special interests convinced the U.S. government to act as insurance exempting those providing vaccines. The government agency covering such vaccine damages has only paid out claims in the billions so far, but this appears to have been based on primarily political concerns rather than science (147, 62,130,146, etc.). The actual costs documented appear to be much higher.
It has been estimated that if all of the vaccines recommended by the American Assoc. of Pediatrics are given and contain thimerosal, then by age 6 months an infant would have received 187 micrograms of ethyl mercury which is more than the EPA/ATSDR health standard for organic mercury (33,41,81) and by age 3 the typical child has received over 235 micrograms of mercury thimerosal from vaccinations which is considerably more than Federal mercury safety guidelines(41,81,501), in addition to significant levels from other sources for many(23). Infants during this period have undeveloped blood brain barriers and much of the mercury goes to the brain, resulting in significant adverse neurological effects in those that are most susceptible (43,3). Neonatal administration of the vaccine preservative, thimerosal, has been found to produce lasting impairment of nociception [pain sense] and apparent activation of opioid system [controls pain, reward and addictive behaviors] in rats, which is similar to brain problems in some children with autism. The mercury load was calculated and injected into the rats that corresponded to what infants receive with vaccines in many countries including the U.S. (575). The bioaccumulation in the brain and toxic effects of ethyl mercury are comparable to that of methyl, with mercury accumulation in the brain and physical effects actually being more extensive (79,88,89).
Researchers on autism have found and are in agreement that autism is primarily caused by various disruptions in the body � s homeostasis that result in a cascade of systemic problems characterized by the term � autism � . (581,etc.) Vaccines and mercury have been found to be something that is capable of causing such a disruption in the body � s homeostasis in susceptible individuals.
III. Mechanisms by which vaccines/mercury/toxic metals are documented to cause Autism Spectrum conditions
1. Brain inflammation from exposure to excitotoxins
Brain inflammation and mitochondrial dysfunction have been found to be a major factor in autism, and in the sometimes-related metabolic syndrome (598,603,158,165,200,210,170,369,572,573, etc.). Causes of oxidative stress and lipid peroxidative related brain inflammation that have been documented include vaccines, mercury, aluminum, excitotoxins such as MSG, aspartame, food additives, and overconsumption of high-fructose corn sweetener. These cause high glutamate levels in the brain and oxidative damage � resulting in inflammation of the brain and immune system, as well as damage to brain microglia cells and the mitochondrial DNA, high triglycerides, metabolic syndrome, etc. (593) These have been found to be factors in most chronic neurological diseases including autism and diabetes . Autism treatment clinics and clinics treating metal reactivity such as (165,101,369,100) (have found treatments that deal with these damages and improve health of those treated (see last treatment section).
The brain has elaborate protective mechanisms for regulating neurotransmitters such as glutamate, which is the most abundant of all neurotransmitters. When these protective regulatory mechanisms are damaged or affected, chronic neurological conditions such as autism can result (593). Mercury and other toxic metals inhibit astrocyte function in the brain and CNS (22,129), causing increased glutamate and calcium related neurotoxicity (129,333,416,496,593). Mercury and increased glutamate activate free radical forming processes like xanthine oxidase which produce oxygen radicals and oxidative neurological damage (142,13).
Nitric oxide related toxicty caused by peroxynitrite formed by the reaction of NO with superoxide anions, which results in nitration of tyrosine residues in neurofilaments and manganese Superoxide Dimustase (SOD) has been found to cause inhibition of the mitochondrial respiratory chain, inhibition of the glutamate transporter, and glutamate-induced neurotoxicity (524,521). Mitochondrial DNA mutations or dysfunction is fairly common, found in at least 1 in every 200 people (275), and toxicity effects affect this population more than those with less susceptibility to mitochondrial dysfunction.
These inflammatory processes damage cell structures including DNA, mitochondria, and cell membranes. They also activate microglia cells in the brain, which control brain inflammation and immunity. Once activated, the microglia secrete large amounts of neurotoxic substances such as glutamate, an excitotoxin, which adds to inflammation and stimulates the area of the brain associated with anxiety (593,598,22). Inflammation also disrupts brain neurotransmitters resulting in reduced levels of serotonin, dopamine, and norepinephrine. Some of the main causes of such disturbances that have been documented include vaccines, mercury, aluminum, other toxic metals, MSG, aspartame, etc. (593,598,22,158,500,582,570,571,572 etc.)
Inflammation induced by vaccine adjuvants like aluminum and mercury or by excitotoxins like MSG has been found to play a significant role in insulin resistance (type-2 diabetes) and in high levels of LDL cholesterol (158,593,597,598, etc.). Type 2 diabetes is an epidemic among young Americans and greatly increases the incidence of heart attack, blindness, stoke, infertility, and early death. There is also evidence that the diet drink sweetener aspartame can cause or increase the effects of diabetes and hypoglycemia (450,498). Iron overload has also been found to be a cause of insulin resistance/type 2 diabetes (595).
Reduced levels of magnesium and zinc are related to metabolic syndrome, insulin resistance, and brain inflammation and are protective against these conditions (599,43). Mercury and cadmium inhibiting magnesium and zinc levels as well as inhibiting glucose transfer are other mechanisms by which mercury and toxic metals are factors in metabolic syndrome and insulin resistance/diabetes (43,198,338,597).
Chronic inflammation due to metals reactivity can be a factor in many conditions such as psycho-neuro-immunological diseases, Autoimmune diseases, Gastrointestinal diseases, Skin diseases, Joint problems, depression, mood disorders, etc. (200,210,215,35,369,382,11,190) Metals reactivity from mercury (organic or inorganic) or vaccine adjuvants causes significant harm at low levels of exposure. Common sources of metals exposure include dental amalgams, thimerosal, vaccination preservatives, and medications. Metals and environmental toxins negatively impact the Neuro-Endo-Immune (NEI) System, which is comprised of the nervous, endocrine, and immune systems. Dysregulation of the immune system is a very likely cause for the increases we are seeing in hypersensitivities and/or autoimmune diseases (139,200,210,35,369,382, AI) . A study of monozygotic and dizygotic twins discordant for ASD tested whether fetal and postnatal metal dysregulation increases ASD risk. Using validated tooth-matrix biomarkers, they estimated pre- and post-natal exposure profiles of essential and toxic elements. Significant divergences were apparent in metal uptake between ASD cases and their control siblings, but only during discrete developmental periods. Cases had reduced uptake of essential elements manganese and zinc, and higher uptake of the neurotoxin lead. Manganese and lead were also correlated with ASD severity and autistic traits. The study suggests that metal toxicant uptake and essential element deficiency during specific developmental windows increases ASD risk and severity, supporting the hypothesis of systemic elemental dysregulation in ASD. Using the Melisa test, metal-specific lymphocyte reactivity is significantly reduced after metal replacement or elimination. For the majority of thousands of patients replacing reactive metals, detoxifying, and supporting immune systems, this has resulted in significant improvement of health (205,210,215,35,369,382, etc.). Clinical tests involving thousands of patients have found that the Melisa test is a reliable and useful test of immune reactivity to metals and other toxins, and the majority of patients improve after eliminating of reactive metals and immune support.
Genetic susceptibility and environmental risk factors appear to be involved in autism. A review found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. Studies have found that many children with autism have a decreased detoxification capacity due to genetic polymorphism. Subsequently, most autistic children have significantly decreased level of reduced glutathione. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal le results in neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. (88,573, Autismhg ) Treatment including avoidance of common causes of immune reactivity, detoxification and supplementation have seen significant improvements in the majority treated (35,200,,205,210,369,382,573)
2. Impairment of methionine synthase function and impairment of folate-depdendent methylation.
The authors of 2 new studies of thimerosal developmental effects (88) write: "Our studies... provide evidence that mercury, aluminum, other heavy metals and the vaccine preservative thimerosal potently interfere with [methionine synthase] activation and impair folate-dependent methylation. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Mercury exposure has been found to cause oxidative damage, reactive oxygen species, and depletion of glutathione in the brain (155,144,97 ). Oxidative damage and depletion of glutathione have been found to be factors in neurological conditions such as bipolar disorder, schizophrenia, depression, etc. (156). Repetitive doses of thimerosal results in neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequent to vaccination, autistic children have significantly decreased level of reduced glutathione. Since each of these agents has been linked to developmental disorders, our findings suggest that impaired methylation, particularly impaired DNA methylation in response to growth factors, may be an important molecular mechanism leading to developmental disorders."
Citing Stajich et al 2002 (J Peds) and Pichichero et al 2002 (Lancet), Waly(88a) et al write: "A single thimerosal-containing vaccination produces acute ethylmercury blood levels of 10-30nM..., and blood samples in 2-month-old infants, obtained 3-20 days after vaccination, contain 3.8-20.6 nM ethylmercury. Our studies therefore indicate the potential for thimerosal to cause adverse effects on [methionine synthase] activity at concentrations well below the levels produced by individual thimerosal-containing vaccines. A second study notes that it has been found that those with autism generally had higher levels of exposure to mercury from their mother � s amalgam fillings or other sources prenatally (88b,50b). Another study on mice supported the autism/thimerosal connection(88c). Many other studies have documented the vaccine/thimerosal connection to autism (91-104,158,570,571).
Because of the evidence the FDA has completed a study and written a letter to vaccine manufacturers asking that mercury be removed from vaccines. The updated letter stated, "The Center for Biologics Evaluation and Research (CBER) has completed its evaluation of the use of thimerosal in vaccines. Our review concluded that reducing or eliminating thimerosal from vaccines is merited (44). The letter pointed to a joint statement by the American Academy of Pediatrics and the United States Public Health Service in 1999, which "called for the removal of thimerosal from vaccines as soon as possible." A Congressional Committee after holding a hearing has also called for elimination of mercury in vaccines as soon as possible. However, it has been documented that most children still receive high levels of mercury in vaccines and that aluminum in vaccines have similar significant adverse neurological effects (158,570,571, etc.). As a solution to high levels of aluminum in the brain, Professor Exley has suggested that we aim to reduce the accumulation of aluminum in our brains through everyday activities. One of the ways that Professor Exley has suggested to help reduce the accumulation of aluminum in the body is by drinking a silicon-rich mineral water . According to Exley, silicon protects the body against the toxicity of aluminum, and by drinking a silicon-rich mineral water, his studies have revealed that the aluminum is removed from the human body through the excretion of urine (175).
Many thousands of parents have reported that their child got such conditions after vaccination, and tests have confirmed high levels of mercury and aluminum in most of those tested, along with other toxic exposures. An additional source of thimerosal to the fetus of women who are RH negative is the 30 micrograms in the RhoGAM shot they receive, which has been found to be a significant factor in autism incidence (86,138). Mothers of children with neurodevelopmental disorders, autism, or ADHD treated by 2 clinics were compared to a set of mothers from a control group of children for Rh-Negativity. Prior to 2002 when thimerosal use in vaccines was reduced, the group of mothers of children with neurodevelopmental disorders or conditions were more than 25% more likely to have Rh-Negativity than mothers of the control group(81d). After 2002, there was no significant difference in Rh-negativity incidence between mothers of children with ND disorders versus controls.
Underweight infants that get the same dose of thimerosal as other infants have also been found to be at special risk. Many of those diagnosed with high mercury levels have also been found to have significant improvement after mercury detoxification (23,30,40,11,35,51,205). Thimerosal had been previously removed from similar preservative uses in eye drops and eye medications after evidence of a connection to chronic degenerative eye conditions.
After over 15,000 law suits were filed in France over adverse effects of the Hepatitis B vaccine, the French Minister of Health ended the mandatory hepatitis B vaccination program for all school children. Adverse effects included neurological disorders and autoimmune disorders such as multiple sclerosis and lupus. (62) Some hospitals in the U.S. also quit recommending certain vaccinations. Dr. Loren Koller, Pathologist and Immunotoxicologist at the College of Veterinary Medicine, Oregon State University, recognized that more is involved in the vaccine effects than just ethylmercury. He mentions aluminum and even the viral agentsbeings used as other possibilities. This is especially important in the face of Dr. RK Gherardi's identification of macrophagic myofascitis, a condition causing profound weakness and multiple neurological syndromes, one of which closely resembled multiple sclerosis. Both human studies and animal studies have shown a strong causal relationship to the aluminum hydroxide or aluminum phosphate used as a vaccine adjuvants(158,570-572,582). More than 200 cases have been identified in European countries and the United States and has been described as an "emerging condition". Some of the neurological problems seen with the use of aluminum hydroxide and aluminum phosphate in vaccines: In two children aged 3 and 5, doctors at the All Children's Hospital in St. Petersburg, Florida described chronic intestinal pseudo-obstruction, urinary retention and other findings indicative of a generalized loss of autonomic nervous system function (diffuse dysautonomia). The 3-year old had developmental delay and hypotonia (loss of muscle tone). A biopsy of the children's vaccine injection site disclosed elevated aluminum levels. In a study of some 92 patients suffering from this emerging syndrome, eight developed a full-blown demyelinating CNS disorder (multiple sclerosis). (584) This included sensory and motor symptoms, visual loss, bladder dysfunction, cerebellar signs (loss of balance and coordination) and cognitive (thinking) and behavioral disorders.
Dr. Gherardi, the French physician who first described the condition in 1998, has collected over 200 proven cases, One-third of these developed an autoimmune disease, such as multiple sclerosis. Of critical importance is his finding that even in the absence of obvious autoimmune disease there is evidence of chronic immune stimulation caused by the injected aluminum, known to be a very powerful immune adjuvant. The reason this is so important is that there is overwhelming evidence that chronic immune activation in the brain (activation of microglial cells in the brain) is a major cause of damage in numerous degenerative brain disorders, from multiple sclerosis to the classic neurodegenerative diseases (Alzheimer's disease, Parkinson's and ALS). In fact, I have presented evidence that chronic immune activation of CNS microglia is a major cause of autism, attention deficit disorder and Gulf War Syndrome. Dr. Gherardi emphasizes that once the aluminum is injected into the muscle, the immune activation persists for years. In addition, we must consider the effect of the aluminum that travels to the brain itself. Numerous studies have shown harmful effects when aluminum accumulates in the brain (158,571, etc.). A growing amount of evidence points to high brain aluminum levels as a major contributor to Alzheimer's disease and possibly Parkinson's disease and ALS (Lou Geherig's disease). This may also explain the 10X increase in Alzheimer's disease in those receiving the flu vaccine 5 years in a row. (Dr. Hugh Fudenberg, Journal of Clinical Investigation). Investigators postulated that early-life exposure to organic mercury (Hg) significantly increases the risk of childhood neurodevelopmental disorders (NDs). The Vaccine Adverse Event Reporting System database was utilized to conduct a hypothesis testing case-control study by evaluating 3486 total adverse event reports reported following Haemophilus influenza type b (Hib) vaccination. Cases of reported autism (odds ratio (OR) = 2.75, p < 0.02), developmental delay (OR = 5.39, p < 0.01), psychomotor disorder (OR = 2.38, p < 0.03), and neurodevelopmental disorder in general (OR = 2.70, p < 0.001) were each significantly more likely than their respective controls to receive Thimerosal-containing Hib vaccine than Thimerosal-free Hib vaccine. Significant effects for neurodevelopmental disorder in general were observed for males (OR = 2.52, p < 0.005) (140).
Clinical experience has shown that males are more affected by toxic damage such as from vaccines (96,140, etc.). The reasons for this have been documented. Based on reviews, the neurotoxicants exhibiting consistent gender‑specific effects, with exposed males being more affected (than similarly exposed females), were: lead, Thimerosal/ethylmercury, some organochlorine pesticides (e.g., dieldrin, endosulfan, and heptachlor), and air pollution. The next group identified were neurotoxicants exhibiting gender‑specific neurotoxic effects, with males being somewhat (but not consistently) more affected than females: mercury vapor, polychlorinated biphenyls (PCBs), and organophosphate pesticides. � The overall conclusion from the studies reviewed was that the brain in males is more vulnerable to many toxic exposures than it is in females. Evidence suggests that the reasons for the male brain being more vulnerable include: (1) greater glutathione availability in females; (2) greater sulfate‑based detoxification capacity in females; (3) potentiating effects of co‑exposure to neurotoxicants and testosterone; (4) greater neuroinflammatory response in males; (5) reduced vulnerability to oxidative stress in females; and (6) neuroprotective effects of female hormones (estrogen and progesterone), especially in the reduction of inflammation and oxidative stress(96, etc.).
Mucocutaneous lymph node syndrome (Kawasaki syndrome) is an autoimmune disease that manifests as a multisystemic necrotizing medium vessel vasculitis that is largely seen in children under 5 years of age, which affects many organs, including the skin, mucous membranes, lymph nodes, and blood vessel walls, but the most serious effect is on the heart where it can cause severe aneurysmal dilations in untreated children. Medical literature, epidemiological findings, and some case reports have suggested that mercury may play a pathogenic role (573). Several patients with Kawasaki's Disease have presented with elevated urine mercury levels compared to matched controls. Most symptoms and diagnostic criteria which are seen in children with acrodynia, known to be caused by mercury, are similar to those seen in Kawasaki's Disease. Genetic depletion of glutathione S-transferase , a susceptibility marker for Kawasaki's Disease, is known to be also a risk factor for acrodynia and may also increase susceptibility to mercury . Coinciding with the largest increase (1985-1990) of thimerosal (49.6% ethyl mercury) in vaccines, routinely given to infants in the U.S. by 6 months of age (from 75microg to 187.5microg), the rates of Kawasaki's Disease increased ten times, and, later (1985-1997), by 20 times. Since 1990 88 cases of patients developing Kawasaki's Disease some days after vaccination have been reported to the Centers of Disease Control (CDC) including 19% manifesting symptoms the same day.
Although vaccinations appear to be the largest source of mercury in many infants, mercury has been found to be transmitted from the mother to the fetus through the placenta and accumulate in the fetus to higher levels than in the mother
s blood(50b,123). Infants of mothers who had dental work involving amalgam during pregnancy had significantly higher levels of mercury in hair tests (78,86). Breast milk of women who have amalgam fillings is the 1
or 2nd largest source of mercury in infants and young children (50b,69), but eating a lot of fish has also been found to be a significant source (45,41).
Cadmium and mercury
was detected in 100% and lead in 87% of breast milk samples from Norwegian mothers (69d). Maternal seafood intake alone explained 10% of variance in mercury exposure, while together with amalgam fillings explained 46% of variance in Hg concentration in breast milk. For Hg concentration in breast milk,
number of amalgam fillings
and high fish consumption were significant predictors of mercury level.
M ilk increases the bioavailability and retention of mercury by as much as double(50b,68,69) and mercury is often stored in breast milk and the fetus at much higher levels than that in the mother's tissues (50b,69). Inorganic mercury has been shown to be excreted to milk from plasma to a higher extent than methylmercury(123c). Mercury is transferred mainly by binding to casein (68,24). The level of mercury in breast milk was found to be significantly correlated with the number of amalgam fillings (69), with milk from mothers with 7 or more fillings having levels in milk approx. 10 times that of amalgam-free mothers. The mercury in milk sampled ranged from 0.2 to 6.9 ug/L. Prenatal mercury exposure can also developmentally damage the metals detox system of the liver which can lead to accumulation and toxicity of later metals exposure (50b).
A group of Chinese children with autism were diagnosed as having mercury toxicity from eating fish as a major factor in their conditions (162). Overall, it was estimated that the children examined received an estimated median mercury dose of 0.40 micrograms mercury / kilogram bodyweight / week (0.06 micrograms mercury / kilogram bodyweight / day). This is a remarkably low dose of mercury considering that children receiving Thimerosal-containing childhood vaccines on average received 10 to 20 micrograms mercury / kilogram bodyweight / day and the US Environmental Protection Agency (EPA) methylmercury safety limit is 0.1 micrograms mercury / kilogram bodyweight / day), and yet these children had very serious adverse outcomes.
A recent study found that prenatal mercury exposures and susceptibility factors such as ability to excrete mercury appear to be a major factors in those with chronic neurological conditions like autism (86). Infants whose mothers received prenatal Rho D immunoglbulin injections containing mercury thimerosal or whose mother � s had high levels of amalgam fillings had a much higher incidence of autism (138). While the hair test levels of mercury of infants without chronic health conditions like autism were positively correlated with the number of the mother � s amalgam fillings, vaccination thimerosal exposure, and mercury from fish, the hair test levels of those with chronic neurological conditions such as autism were much lower than the levels of controls and those with the most severe effects had the lowest hair test levels, even though they had high body mercury levels. This is consistent with past experience of those treating children with autism and other chronic neurological conditions (23). Very low levels of exposure have been found to seriously affect relatively large groups of individuals who are immune sensitive to toxic metals (11,35), or have an inability to detoxify metals due to such as deficient sulfoxidation or metallothionein function (18,36,51,205) or other inhibited enzymatic processes related to detoxification (15-24,30) or excretion of metals (87). Those with the genetic allele ApoE4 protein in the blood have been found to detox metals poorly and to be much more susceptible to chronic neurological conditions than those with types ApoE2 or E3(87). For a group of 465 patients, removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p<0.001) to levels reported by healthy subjects.
3. Mercury and toxic metals block enzymes required to digest milk casein and wheat gluten, resulting in dumping morphine like substances in the blood that are neurotoxic and psychotic, as a major factor in schizophrenia, autism, and ADHD.
A direct mechanism involving mercury � s inhibition of cellular enzymatic processes by binding with the hydroxyl radical (SH) in amino acids appears to be a major part of the connection to these allergic/immune reactive conditions (15-23,36,47,51,98). For example mercury has been found to strongly inhibit the activity of xanthine oxidase and dipeptyl peptidase (DPP IV) which are required in the digestion of the milk protein casein or wheat protein gluten (15,16,17,19,20,500,23-26,98,105), and the same protein that is cluster differentiation antigen 26 (CD26) which helps T lymphocyte activation. CD26 or DPPIV is a cell surface glycoprotein that is very susceptible to inactivation by mercury binding to its cysteinyl domain. Mercury and other toxic metals also inhibit binding of opioid receptor agonists to opioid receptors, while magnesium stimulates binding to opioid receptors (15). Studies involving large samples of patients with autism, schizophrenia, or mania found that over 90 % of those tested had high levels of the milk protein beta-casomorphine-7 in their blood and urine and defective enzymatic processes for digesting milk protein(24,25,27), and similarly for the corresponding enzyme needed to digest wheat gluten(24,26). Like casein, gluten breaks down into molecules with opioid traits, called gluteomorphine or gliadin. As with caseomorphin, it too can retain biological activity if the enzymes needed to digest it are not functioning properly.
Proteins in bovine milk are a common source of bioactive peptides. The peptides are released by the digestion of caseins and whey proteins (105). In vitro the bioactive peptide beta-casomorphin 7 (BCM-7) is yielded by the successive gastrointestinal proteolytic digestion of bovine beta-casein variants A1 and B, but this was not seen in variant A2 or in goats milk. In hydrolysed milk with variant A1 of beta-casein, BCM-7 level is 4-fold higher than in A2 milk. Variants A1 and A2 of beta-casein are common among many dairy cattle breeds. A1 is the most frequent in Holstein-Friesian (0.310 � 0.660), Ayrshire (0.432 � 0.720) and Red (0.710) cattle. In contrast, a high frequency of A2 is observed in Guernsey (0.880 � 0.970) and Jersey (0.490 � 0.721) cows (105). In children with autism, most of whom have been found to have been exposed to high levels of toxic metals through vaccines, mother � s dental amalgams, or other sources; higher levels of BCM-7 is found in the blood (24-26).
BCM-7 appears to play a significant role in the aetiology of human diseases (105). Epidemiological evidence from New Zealand claims that consumption of beta-casein A1 is associated with higher national mortality rates from ischaemic heart disease. It appears that the populations that consume milk containing high levels of beta-casein A2 have a lower incidence of cardiovascular disease and type 1 diabetes. Beta-casomorphin-7 has opioid properties including immunosuppression, which account for the specificity of the relation between the consumption of some but not all beta-casein variants and diabetes incidence. BCM-7 has also been suggested as a possible cause of sudden infant death syndrome (SIDS). In addition, neurological disorders, such as autism and schizophrenia, appear to be associated with milk consumption and a higher level of BCM-7 (105).
The studies found high levels of Ig A antigen specific antibodies for casein, lactalbumin and beta-lactoglobulin and IgG and IgM for casein. Beta-casomorphine-7 is a morphine like compound that results in neural disfunction (24,25), as well as being a direct histamine releaser in humans and inducing skin reactions (14,21,25c). Similarly many also had a corresponding form of gluten protein with similar effects (24,26). Elimination of milk and wheat products and sulfur foods from the diet has been found to improve the condition(100,28,etc.). A double blind study using a potent opiate antagonist, naltrexone (NAL), produced significant reduction in autistic symptomology among the 56% most responsive to opioid effects (28). The behavioral improvements wasaccompanied by alterations in the distribution of the major lymphocyte subsets, with a significant increase in the T-helper-inducers and a significant reduction of the T-cytotoxic-suppressors and a normalization of the CD4/CD8 ratio. Studies have found mercury causes increased levels of the CD8 T-cytotoxic-suppressors (29). As noted previously, such populations of patients have also been found to have high levels of mercury and to recover after mercury detoxification (23,11,500,30,40,100,205). As mercury levels are reduced the protein binding is reduced and improvement in the enzymatic process occurs (500,11,96). The neurotoxic effects of such opioid mechanisms has also been found to be a factor in multiple sclerosis, and low dose naltrexone (LDN) has been found to often be effective in reducing MS symptoms and exerbations (115).
Lactose (milk sugar), which is a major component of milk, is a disaccharide sugar made up of the simple sugars, glucose and galactose (132). Lactase is an enzyme which facilitates digestion of lactose. Over 50% of non-Caucasians are lactose intolerant, to a significant degree and about 20% of Caucasians. Infants are most lactose tolerant but lactase activity declines dramatically over time so that by adulthood to about 5 to 10 % of the level of infants. Only a relatively small percentage of people retain enough lactase activity to absorb significant amounts of lactose throughout their adult life (132). Lactose intolerance results in undigested lactose in the intestines which often causes gas, bloating, abdominal discomfort, and proliferation of bacteria in the intestines. In addition to inhibiting the enzymes required to digest milk casein and whey, chronic mercury exposure in animals has also been found to inhibit lactase and glucose-6-phosphatase needed to digest lactose and other polysaccharides (19b). Thus, chronic exposure to mercury and toxic metals also increases lactose intolerance and digestion problems of carbohydrates in general. Digestive problems have been found to commonly be improved by reducing chronic mercury and toxic metal exposures.
Lactose intolerance can also be alleviated to some degree by supplemental enzymes, using fermented milk products such as yogurt or kefir, or using only small amounts of milk products spread throughout the day(132).
Studies have also found heavy metals to deplete glutathione and bind to protein-bound sulfhydryl SH groups, resulting in inhibiting SH-containing enzymes and production of reactive oxygen species such as superoxide ion, hydrogen peroxide, and hydroxyl radical(39,43,45-47, 63-65,89,97,500). In addition to forming strong bonds with SH and other groups like OH,NH2, and Cl in amino acids which interfere with basic enzymatic processes, toxic metals exert part of their toxic effects by replacing essential metals such as zinc at their sites in enzymes. An example of this is mercury � s disabling of the metallothionein protein, which is necessary for the transport and detoxification of metals. Mercury inhibits sulfur ligands in MT and in the case of intestinal cell membranes inactivates MT that normally bind cuprous ions (66), thus allowing buildup of copper to toxic levels in many and malfunction of the Zn/Cu SOD function. Another large study(51) found a high percentage of autistic and PDD children are especially susceptible to metals due to the improper functioning of their metallothionein detoxification process, and that with proper treatment most recover or significantly improve. Mercury has also been found to play a part in neuronal problems through blockage of the P 450 enzymatic process (67,89). Another study found accelerated lipofuscin deposition--consistent with oxidative injury to autistic brain in cortical areas serving language and communication (97). Compared with controls, children with autism had significantly higher urinary levels of lipid peroxidation. Double-blind, placebo-controlled trials of potent antioxidants--vitamin C or carnosine--significantly improved autistic behavior.
4. Mercury induced reactive oxygen species and lipid peroxidation has been found to be a major factor in mercury � s neurotoxicity, along with leading to decreased levels of glutathione peroxidation and superoxide dismustase (SOD) (63,89). This has been found to be a major factor in neurological and immune damage caused by the heavy metals, including damage to mitochondria and DNA (63,500,572), as well as chronic autoimmune conditions and diseases (35,104,369,382,500)
Additional cellular level enzymatic effects of mercury � s binding with proteins include blockage of sulfur oxidation processes such as cysteine dioxygenase, gamma glutamyltranspeptidase(GGT), and sulfite oxydase, along with neurotransmitter amino acids which have been found to be significant factors in many autistics(18,36,47,17,100c), plus enzymatic processes involving vitamins B6 and B12, with effects on the cytochrome-C energy processes as well. For example, the Vitamin B6 activating enzyme, B6-kenase, is totally inhibited in the intestine at extremely low (nanamolar) concentrations (56). Epson salts (magnesium sulfate) baths, supplementation with the p5p form of Vit B6, N-acetyl cysteine (89), and vit B12 shots are methods of dealing with these enzymatic blockages that have been found effective by those treating such conditions. Mercury has also been found to have adverse effects on cellular mineral levels of calcium, magnesium, zinc, and lithium (39,500,47,50,100c,581b). Supplementing with these minerals has also been found to be effective in the majority of cases (39,50,100c,581b), and lithium oratate has even been found to cause regeneration of neurons in damaged areas of the brain such as the hippocampus. Another of the results of these toxic exposures and enzymatic blockages is the effect on the liver and disfunction of the liver detoxification processes which autistic children have been found to have (30,36,51,500,581b). All of the autistic cases tested were found to have high toxic exposures/effects and liver detoxification profiles outside of normal (30a).
5. Another aspect of gastrointestinal dysfunction that is found in the majority of autism cases are intestinal inflammation, enterocolalitis, lymphondular hyperplsia, abnormal intestinal permeability, or malabsorption (17,53,580). The intestinal damage also causes improper functioning of the buffering mechanism that maintains blood PH and of enzyme functions. Such damage to the intestines and gastrointestinal processes are known from animal studies to be caused by mercury and other toxic metals (54). Inorganic mercury is the predominant excretionary form in the intestines, whatever the source form. All forms are absorbed by the intestines and inorganic mercury accumulates in intestinal tissues, especially in young animals or infants (55), which are known to have poor biliary excretion of mercury. As noted previously children in the U.S. are exposed to high levels of mercury thimerosal, a highly toxic organic form of mercury. Organic mercury in primate studies is found to cause paneth cells in the intestines to be enlarged and packed with secretionary granules (57). This is also common in autistic children (17c).
Along with these blockages of cellular enzymatic processes, mercury has been found to cause additional neurological and immune system effects in many through immune/autoimmune reactions (11,12,35,104). Mercury (32b,500) as well as thimerosal(31,32a), aluminum(32c,158), and other toxic metals (50) also have direct neurotoxic effects on brain nucleoid binding proteins through their effect on Ca2+ATPase and Na+/K+ATPase activity. But the effects on the neurological and immune systems of exposure to various toxic substances such as toxic metals and environmental pollutants has also been found to have additive or synergistic effects and to be a factor in increasing eczema, allergies, asthma, delayed food allergies, and sensitivity to other lesser allergens(14,500,582,35,50). Most of the children tested for toxic exposures have found high or reactive levels of other toxic metals, and organochlorine compounds (30,40,11,12,35,48). Other than the organochlorines or toxic metals which are discussed later, three common pollutants that have been documented to have effects on such conditions are traffic and industrial pollutants nitrogen oxide, power plant residual oil fly ash, and organochlorine pollutants (48).
Mercury has also been found to cause reduced acetylycholine levels (77) and to be a factor in autism. When the author succeeded in removing excessive metal deposits using cilantro and upregulation techniques, he found Acetylcholine suddenly increased towards a normal level, short-term memory, the ability to concentrate and think clearly improved significantly; and often those who had abnormal or anti-social and irritable behavior returned to more acceptable behavior.
Another effect of mercury and toxic metals is a reduction in B- lymphocytes (37,38,50,500). Many studies(37,580) dealing with autistic patients and further work with such patients has found toxic metal exposure causes a tendency to be more seriously affected by viruses and to develop intestinal disorders including leaky gut, lymphoid modular hyperplasia, and a high incidence of parasites. Gut disease with inflammation has become increasingly evident in autism(37). Enterocolitis and lymphonodular hyperplasia are found in nearly 90% of regressed autistic children (37d). Widespread inflammatory changes with poor intestinal digestive enzyme activity, abnormal intestinal permeability, and malabsorption have been reported in various autistic subgroups(37e,580). Studies have found that mercury has similar effects on animals (37b,42).
6. A mechanism by which vaccines such as MMR trigger autism by causing a loss of homeostasis between the amino acids glycine and glutamate has been demonstrated (137,581). Also, mercury exposure has been shown to disrupt immune system homeostasis making the systems more susceptible to infectious agents such as measles virus and other viruses (22,598). The stabilizer in MMR and a few other vaccines is hydrolyzed gelatin; a substance that is approximately 21% glycine. It appears that, based on studies, that the use of that form of glycine triggers an imbalance between the amino acid neurotransmitters responsible for the absorption rate of certain classes of cells throughout the body. It is that wide-spread disruption that apparently results in the systemic problems that encompass the mind and the body characterized in today's 'classic' autism." The authors also added, "The use of our model indicates each of the disorders within Autism Spectrum Disorder (ASD) is attributable to different disruptions in homeostasis.
Metals by binding to SH radicals in proteins and other such groups can cause autoimmunity by modifying proteins which via T-cells activate B-cells that target the altered proteins inducing autoimmunity as well as causing aberrant MHC II expression on altered target cells(72). Studies have found that various protein related disorders such as misfolded proteins are found in some autism cases(596b). The mechanisms by which mercury and other toxics or allergens cause protein abnormalities have been discussed throughout this paper.
Studies have also found mercury, aluminum, and lead cause autoantibodies to neuronal proteins, neurofilaments, and myelin basic protein (73,74,104,158,571). While zinc binding with MBP stabilizes the association with brain myelin, mercury and cadmium have been found to interfere with zinc binding to MBP and thus cause disfunction and autoimmunities (74). Dr. Stejskal (11) recently began testing children with autism. Her preliminary results on 18 autistic children and 11 controls, found that 5 of 18 autistic children had a positive proliferative ("allergic") response on MELISA to Thimerosal, vs. 1/11 controls. Similar results were recently found for methyl mercury (6/10 autistics vs 0/11 controls) and inorganic mercury (6/18 autistics, vs 0/11 controls). Most importantly, 13/16 autistics tested positive for reactivity to the mercury-MBP vs. only 3/10 controls. The mercury-MBP reactivity is presumed to be caused by the mercury reconfiguring the three-dimensional MBP, to which the body generates the allergic (autoimmune) response. In another study a significant percentage of children with autism developed anti-SK, anti-gliadin and anti-casein peptides and anti-ethyl mercury antibodies, concomitant with the appearance of anti-CD26 and anti-CD69 autoantibodies (89). These antibodies are synthesized as a result of SK, gliadin, casein and ethyl mercury binding to CD26 and CD69, indicating that they are specific. The study found that bacterial antigens (SK), dietary peptides (gliadin, casein) and Thimerosal (ethyl mercury) in individuals with pre-disposing HLA molecules, bind to CD26 or CD69 and induce antibodies against these molecules. Immune mechanisms are thus seen to be a major factor in neurotoxicity of metals seen in conditions such as autism and ADD (112,63,72-74).
8. Parathyroid Hypertensive Factor (PHF) is produced by the parathyroid gland and is measurable by the University of Alberta. Preliminary PHF determinations on over 100 patients through the Pfieffer Treatment Center have revealed very high levels for autistic patients. Heavy metals are known to block calcium L-channels at the cell membrane, whereas PHF is known to open calcium L-channels [84a] and stimulate phosphodiesterase [84b]. Calcium L-channels perform numerous functions, including initiation of transcriptional events which support learning, memory and endocrine secretion. Mercury inhibits L-channels at micromolar concentration [84c] in an irreversible manner in hippocampal neurons. Hypothetically, elevated PHF may serve to at least partially compensate Hg-inhibition of L-channels. Mercury is also a potent inhibitor of cAMP [84d], cellular levels of which presumably further decrease with PHF-stimulation of phosphodiesterase. Thus, in the context of mercury toxicity, PHF may play both adaptive and maladaptive roles. The very mechanism of mercury-induced auto-immune disease in mercury-sensitive rats is related to L-channel signaling. This process involves induction of interleukin-4 gene expression, which is mediated by protein kinase C-dependent calcium influx through L-channels [84e]. PHF hypothetically may affect the auto-immune response
9. An IRB approved study assessing urinary levels of porphyrins found an apparent dose-response effect between autism severity and increased urinary coproporphyrins (91). For patients with non-chelated autism (83% had levels > 2 SD above the control mean) and for children with non-chelated AutismSpectrumDisorders (58% had levels > 2 SD above the control mean), but for patients with non-chelated pervasive developmental delay-not otherwise specified (PDD-NOS) or Asperger's disorder (46% had levels > 2 SD above the control mean). Each group of ASDs had significantly increased median coproporphyrin levels versus controls. A significant increase (1.7-fold) in median coproporphyrin levels was observed among non-chelated ASD patients versus chelated ASD patients. Mercury toxicity was found to be associated with elevations in urinary coproporphyrin (cP), pentacarboxyporphyrin (5cxP), and precoproporphyrin (prcP) (also known as keto-isocoproporphyrin) levels. Two cohorts of autistic patients in the United States and France each had urine porphyrin levels associated with mercury toxicity. Another study using chelation therapy on a group of autistic patients found significant improvement during the study period (96).
Following up other studies showing higher than normal androgen levels in most autistic patients, a study found increased androgen levels in virtually all of a group of autistics. Morning blood samples collected following an overnight fast, compared to the pertinent reference means, showed significantly increased relative mean levels for: serum testosterone (158%), serum free testosterone (214%), percent free testosterone (121%), DHEA (192%), and androstenedione (173%). A medical hypothesis has suggested that some autism spectrum disorders (ASDs) may result from interactions between the methionine cycle-transsulfuration and androgen pathways following exposure to mercury. A study following treatment including chelation using DMSA and Lupron brought significant improvement in the majority of patients (96). A significant (p<0.01) overall improvement from the 70-79th percentile of severity at baseline to the 40-49th percentile of severity at the end of the study was observed for patients treated for a median of approximately 4 months. Significant improvements in sociability, cognitive awareness, behavior, and clinical symptoms/behaviors of hyperandrogenemia were also observed. Significant decreases in blood androgens and increases in urinary heavy metal concentrations were observed. Minimal drug adverse effects were found.
10. Another disorder caused by metals/vaccine exposure is pyrroluria, which about 50% of autistic and Schizophrenic children have been found to have. (585)
IV. Hypothyroidism during pregnancy as cause of developmental delays, reduced IQs, and autism- the mercury and toxic metal connection.
Studies have documented that mercury causes hypothyroidism (150,84,390,407), damage of thyroid RNA(458), autoimmune thyroiditis (369,382,191), and impairment of conversion of thyroid T4 hormone to the active T3 form (369,382,390,407,150d). These studies and clinical experience indicate that mercury and toxic metal exposures appear to be the most common cause of hypothyroidism and the majority treated by metals detoxification recover or significantly improve (503,205).
The estimated prevalence of hypothyroidism from a large federal health survey, NHANES III, was 4.6%, but the incidence was twice as high for women as for men and many with sub clinical hypothyroidism are not aware of their condition(113a). Another large study(113b) found that 11.7% tested had abnormal thyroid TSH levels with 9.5% being hypothyroid and 2.1% hyperthyroid. According to survey tests, 8 to 10 % of untreated women were found to have thyroid imbalances so the actual level of hypothyroidism is higher than commonly recognized (508). Even larger percentages of women had elevated levels of antithyroglobulin(anti-TG) or antithyroid peroxidase antibody(anti-TP). Tests have found approx. 30% of pregnant women to have low free T4 in the first trimester(509b).
Thyroid hormones are of primary importance for the perinatal development of the central nervous system, and for normal function of the adult brain (109a). Hypothyroidism of the adults causes most frequently dementia and depression. Nearly all the hyperthyroid patients show minor psychiatric signs, and sometimes psychosis, dementia, confusion state, depression, apathetic thyrotoxicosis, thyrotoxic crisis, seizures, pyramidal signs, or chorea occur(109a). These hormones primarily regulate the transcription of specific target genes. They increase the cortical serotonergic neurotransmission, and play an important role in regulating central noradrenergic and GABA function.
Studies indicate that slight thyroid deficiency/imbalance (sub clinical) during the perinatal period can result in delayed neuropsychological development in neonate and child or permanent neuropsychiatric damage in the developing fetus or autism or mental retardation (109,509,511). Low first trimester levels of free T4 and positive levels of anti-TP antibodies in the mother during pregnancy have been found to result in significantly reduced IQs (509a-e) and causes psychomotor deficits(509f). Women with the highest levels of thyroid-stimulating-hormone(TSH) and lowest free levels of thyroxin 17 weeks into their pregnancies were significantly more likely to have children who tested at least one standard deviation below normal on an IQ test taken at age 8(509a). Based on study findings, maternal hypothyroidism appears to play a role in at least 15% of children whose IQs are more than 1 standard deviation below the mean, millions of children. Overt autoimmune thyroiditis is preceded by a rise in levels of thyroid peroxidase antibodies. "Collectively, reports show that 30-60% of women positive for TPO antibodies in pregnancy develop postpartum thyroiditis," the researchers point out (561,108), calling it "a strong association." Without treatment, many of the women with thyroiditis go on to develop overt clinical hypothyroidism as they age and, eventually, associated complications such as cardiovascular disease. About 7.5% of pregnant women develop thyroiditis after birth (108). Studies have also established a connection between maternal thyroid disease and babies born with heart defects (509h).
Infants of women with hypothyroxinemia at 12 weeks' gestation had significantly lower scores on the Neonatal Behavioral Assessment Scale orientation index compared with subjects(109b). Regression analysis showed that first-trimester maternal free thyroid hormone T4 was a significant predictor of orientation scores. This study confirmed that maternal hypothyroxinemia constitutes a serious risk factor for neurodevelopmental difficulties that can be identified in neonates as young as 3 weeks of age.
Mercury (especially mercury vapor from dental amalgam or organic mercury) rapidly crosses the blood brain barrier and is stored preferentially in the pituitary gland, thyroid gland, hypothalamus, and occipital cortex in direct proportion to the number and extent of dental amalgam surfaces (114,119,185,199,273,274,407), and likewise rapidly crosses the placenta and accumulates in the fetus including the fetal brain and hormone glands at levels commonly higher than the level in the mother(120,122-127). Milk from mothers with 7 or more mercury amalgam dental fillings was found to have levels of mercury approximately 10 times that of amalgam free mothers (1500). The milk sampled ranged from 0.2 to 57 ug/L. In a population of German women, the concentration of mercury in early breast milk ranged from 0.2 to 20.3 ug/L (126). A Japanese study found that the average mercury level in samples tested increased 60% between 1980 and 1990. The study found that prenatal Hg exposure is correlated with lower scores in neurodevelopmental screening, but more so in the linguistic pathway (125). The level of mercury in umbilical cord blood, meconium, and placenta is usually higher than that in mother's blood [123-125].
Alterations of cortical neuronal migration and cerebellar Purkinje cells have been observed in autism. Neuronal migration, via reelin regulation, requires triiodothyronine (T3) produced by deiodination of thyroxine (T4) by fetal brain deiodinases (407). Experimental animal models have shown that transient intrauterine deficits of thyroid hormones (as brief as 3 days) result in permanent alterations of cerebral cortical architecture reminiscent of those observed in brains of patients with autism. Early maternal hypothyroxinemia resulting in low T3 in the fetal brain during the period of neuronal cell migration (weeks 8-12 of pregnancy) may produce morphological brain changes leading to autism. Insufficient dietary iodine intake and a number of environmental antithyroid and goitrogenic agents can affect maternal thyroid function during pregnancy.
Mercury can have significant effects on thyroid function even though the main hormone levels remain in the normal range, so the usual thyroid tests are not adequate in such cases. Prenatal methylmercury exposure severely affects the activity of selenoenzymes, including glutathione peroxidase (GPx) and 5-iodothyronine deiodinases(5-Di and 5'-DI) in the fetal brain, even though thyroxine(T4) levels are normal(390e). Gpx activity is severely inhibited, while 5-DI levels are decreased and 5'-DI increased in the fetal brain, similar to hypothyroidism. Thus, normal thyroid tests will not pick up this condition.
Mercury reduces the bloods ability to transport oxygen to fetus and transport of essential nutrients including amino acids, glucose, magnesium, zinc and Vit B12 (143,196,198,263,264,338, 339,427); depresses enzyme isocitric dehydrogenase (ICD) in fetus, causes reduced iodine uptake, autoimmune thyroiditis, & hypothyroidism. (150,191,212,222,369,382,407,135). Because of the evidence of widespread effects on infants, the American Assoc. of Clinical Endocrinologists advises that all women considering becoming pregnant should get a serum thyrotropin test so that hypothyroidism can be diagnosed and treated early(558,17b). Since mercury and toxic metals are common causes of hypothyroidism, another test that should be considered is a hair element test for mercury or toxic metal exposures and essential mineral imbalances.
An ecological study in Texas has correlated higher rates of autism in school districts affected by large environmental releases of mercury from industrial sources.
In addition to large numbers of cases affecting infants, allergic contact eczema is the most frequent occupational disease (1,500,82); and the most common cause of contact eczema is exposure to toxic metals (1, 6-12,500). The metals most commonly causing allergic immune reactivity are nickel, mercury, chromium, cobalt, and palladium (1,6-14,500). The highest level of sensitization is to Infants, who are most reactive to thimerosal, a form of mercury that has been used as a preservative in vaccines and eye drops(6,7). Many with immune reactive conditions like eczema and psoriasis recover after tests and treatment for the cause of the immune reactivity (11,500).
V. Conclusion and Treatments
There has been strong suggestive and clinical evidence for a connection between toxic metals and autism spectrum conditions(2bcd,15-40,50,92,103,603) and recent studies using government databases have confirmed the connection (80,91,92). There also appear to be subgroups of exposure and symptom patterns among the many different types of persuasive developmental disorders (PDD) including autism, Asperger � s syndrome, obsessive compulsive disorder (OCD), dyslexia, ADD/ADHD, learning disabilities, childhood depression, etc.
Some of the apparent subgroups of autism include: the group with blocked enzymatic processes needed to properly digest casein and gluten , a group related to blockage by toxic metals of methionine synthase function, a group related to mother � s hypothyroid condition during the first trimester of pregnancy(due to metals effects), a group of general brain-related encephalies and/or immune effects of toxic exposures(23), the Singh subgroup of autoimmune reactions to brain myelin sheath or other autoimmunity (112), the reduced B lymphocyte/MMR subgroup with intestinal leaky gut and/or involvement of measles virus(37,581), and the Megson/DPT visual abnormality related group(49). Since most children have been found to have high levels of toxic exposure, most of those affected appear to have symptoms related to both the first subgroup plus often one or more of the other exposures/subgroups. The Megson group are often helped significantly by treatment with Vitamin A from cod liver oil(581b) and urocholine. Thousands of autistic children are being treated for metals toxicity using chelation protocols after tests have documented high exposures to mercury and other toxic metals, and the majority have shown significant improvement (23,40,51,81,96,100,133,205). In a large survey of parents of autistic children by the Autism Research Institute of treatment success in treating autism, chelation/detoxification with nutritional support was found to be by far the most effective and least harmful treatment of all treatments surveyed, with over 73% of those using chelation protocol improving significantly after treatment (100). Autism treatment clinics testing and treating autism usually find high toxic metal body burdens and successful cognitive and behavioral treatment results as toxic metal body burden declines and metabolic imbalances are improved (101,133,205,603). Most of those using chelation/nutrition protocol recovered or significantly improved and are doing well in school.
Most children with autism have been found to have gastrointestinal damage and leaky gut , as well as damaged enzymatic process and damaged systems that control blood PH. This results in digestive dysfunction, inability to absorb minerals and nutrients, nutritional deficiencies, damage to autonomic nervous system, and neurological and behavioral problems. Supplements to deal with these nutritional deficiencies and imbalances are needed to alleviate these problems. These problems also cause proliferation of unfriendly bacteria, yeast, and parasites (580,603), for which supplementation with probiotics and Saccharomyces boulardii yeast are helpful. Treatment is complicated and individual, usually requiring detoxification as well as protocols to deal with the dysfunctional gastrointestinal, immune, and hormone systems (205,580). Lists of doctors with experience at successfully treating these problems can be found at the Autism Research Institute website: www.autism.com/ari/ . Some deficiencies usually found include sulfates, magnesium, zinc, essential fatty acids, vit A, vit E, selenium, etc. (580). Supplementation for these and other essential minerals and nutrients are needed due to the dysfunctional digestive systems. A large double-blind study of autistic patients found a nutritional approach using 400 mg carnosine, 50 IU vit E, and 5 mg of zinc two times per day to be highly beneficial (580). Large numbers of autistic children have shown significant improvement after detoxification and biomedical nutritional treatment (100,133,603). A program found to significantly improve most children with with autism spectrum conditions including ADHD is Brain Balance (163). Information on low budget ABA (Applied Behavioral Analysis) can be found at: (600). Properly formulated nutritional treatments have also been found to be effective in treating ADHD and depression (522,205).
A large survey of thousands of parents of autistic children by Autism Research Institute asked parents to rate the effectiveness of many medical and non-medical diet and supplements options (100). � The parent � s survey results indicated that mercury/metals detox(chelation) was by far the most effective medical treatment with 74% of parents saying their child improved. Hyperbaric Oxygen treatment had 65% improved. The 3rd most effective treatment was the anti-fungal Diflucan at 62% improved. The other most effective measures were dietary or nutritional. Vitamin B12 (subcut) with 72% improved, food allergy treatment at 67% improved, digestive enzymes at 62% improved, CLO supplement had 55% improved. �� Special Diet results were: Gluten- /Casein- Free Diet 69% improved; Candida Diet 58% improved; Feingold Diet 58% improved; Removed Milk Products /Dairy 55% improved; Remove Wheat 55 % improved; Removed Sugar 52% improved. � Other clinics such as a Baton Rouge Autism Clinic also found a common mercury/metals connection in autism and that detox/chelation after appropriate testing was usually helpful (101), similar regarding supplements that help and diet (165). � The Rossignol Medical Center(165b) found mitochondrial dysfunction in many autism cases and found that low pressure HBOT treatment with proper oxidative stress support along with carnitine and a milk-free diet to be helpful in such cases- see article. The center has also found(165a) the core problems often related to autism include toxicity (heavy metals, pesticides); inflammation; oxidative stress, impaired glutathione production; and impaired mitochondrial function. In addition to a gluten/casein free diet, avoiding food additives, food allergy testing, see Table 1 in article for immune support supplementation guidelines. � The center also found many cases with folate and B vitamin deficiency, with folinic acid, vit B12, etc. used to normalize 5-MTHF levels which are often found abnormal in autism. ��
Physical activity has been found to help kids who may be restless or hyperactive, or who have been diagnosed with ADHD . Even emotional disturbances can be improved with exercise, as the activity provides an outlet for their energy and reduces the natural inclination of children to � act out. � Use of exercise therapy along with Emotional Freedom Technique (EFT) were found to have significant benefits (574). Exercise at school was also found to significantly increase reading and math ability of students, in addition to helping control obesity.
(1) (a)Weiss B, Landrigan PJ. The developing brain and the Environment. Environmental Health Perspectives, Volume 107, Supp 3, June 2000; & (b) EPA spokesman, U.S. News & World Report, Kids at Risk (cover story), 6-19-2000; & Frith CD et al, More Dyslexia in English Speaking Countries, Science, Mar 2001; & EPA spokesman, U.S. News & World Report, In the Air that they Breathe, Science & News, 12-20-99; & U.S. EPA, Region I, 2001 ; & Dr. Fionta Stanley, Department of Paediatrics, the University of Western Australia Before the bough breaks: 21 st Century kids in crisis, Zonta International Conference, Gothenburg Sweden, July 2, 2002 www.zonta.org/Member_Resource_Center/StanleySpeech.pdf & (b) NIAID adverse effects, www.myflcv.com/conditins.html ; search for NSAID
& (c) ATSDR/EPA Priority List for 2017: Top 20 Hazardous Substances , Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services,
& U.S. CDC, National Center for Environmental Health, National Report on Human Exposure to Environmental Chemicals, 2001 www.cdc.gov/nceh/dls/report/Highlights.htm
& (d) Agency for Toxic Substances and Disease Registry, U.S. Public Health Service. Toxicological Profile for Mercury ", March 1999; & Jan 2003 Media Advisory, New MRLs for toxic substances, MRL: elemental mercury vapor/ inhalation/chronic & MRL: methyl mercury/oral/acute; & https://www.atsdr.cdc.gov/mrls/mrllist.asp , 2017
(2) (a)The Center for Education Statistics, http://nces.ed.gov/; & Annual Report to Congress on the implementation of the Individuals with disabilities act. http://www.ed.gov/offices/OSERS/OSEP/ (1994 to 1998); & U.S. Dept. of Education, Office of Special Education Programs, Data Analysis Section, partB, Chapter1: 1990-1997; & (b) State government agency reports on autism incidence trends for the last decade for California, New Jersey, Maryland, Rhode Island, Illinois, Pennsylvania, Colorado, Washington, etc. in: Autism 99 : A National Emergency, http://www.garynull.com/documents/autism_99.htm; & � Gary Null, Second Opinion: Vaccinations, Gary Null and Associates, Inc. 2000, http://www.garynull.com/marketplace/documents.asp & (d) Bernard Rimland, Ph.D, Autism Research Institute, The Autism Epidemic Is Real, and Excessive Vaccinations Are the Cause , www.autismcanada.org/News/RimlandstatementJuly2003.htm (e) California Department of Developmental Services (DDS), � Autistic Spectrum Disorders, Changes in the California Caseload: 1999-2002 � . May 2003;
(3)(a) National Academy of Sciences, National Research Council, Committee on Developmental Toxicology, Scientific Frontiers in Developmental Toxicology and Risk Assessment, June 1, 2000, 313 pages. & Press Release; &(b) Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council National Academy Press, 262 pages, 6 x 9, 2001; & (c) National Environmental Trust (NET), Physicians for Social Responsibility and the Learning Disabilities Association of America, "Polluting Our Future: Chemical Pollution in the U.S. that Affects Child Development and Learning" Sept 2000; ; & (d) The Increase of Childhood Chronic Conditions in the U.S., JAMA, 2007, Jun 27, 297(24):2755-9; & (e) J Van Cleave et al, National Longitudinal Survey of Youth-Child (NLSY) Cohort (1988 - 2006) JAMA. 2010;303: 623-630, 665-666.
(4) American Academy of Pediatrics, American J of Psychiatry, 2000, 157:1077 1083; & American Academy of Pediatrics, Report to Clinicians; & James A Kaye, Maria del Mar
Melero Montes, Hershel Jick; Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, 11 Muzzey Street, Lexington, MA 02421, USA, 2000, National Vaccine Information Center & (e) Vaccination Schedule Comparison- 2007 vs 1983 (0 to 6 years) (36 vs 10 vaccinations & more multiple) http://www.generationrescue.org/
(5) American Academy of Dermatology, Press Release, February, 2000; & Silhan P, Arenberger P. Standard epicutaneous tests in ambulatory care of patients. Cas Lek Cesk 1999, 138(15):469-73; & (b)
Rook GAW, Stanford JL. Give us this day our daily germs. Immunol Today 1998; 19: 113-6;& Kemp T, Pearce N, Fitzharris P, et al. Is infant immunization a risk factor for childhood asthma or allergy? Epidemiology 1997; 8: 678-80; & Odent MR, Culpin EE, Kimmel T. Pertussis vaccination and asthma: is there a link? [Letter]. JAMA 1994:592-3.
Blomfield R. Childhood vaccination should have been included in asthma study [Letter]. BMJ 1998; 317: 205; & Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax 1998; 53: 927-32; & Hurwitz EL, Morgenstern H. Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States. J Manipulative Physiol Ther 2000; 23: 81-90; &
(c ) Hedenskog S, Bjorksten B, Biennow M, Granstrom G, Granstrom M. Immunoglobulin E response to pertussis toxin in whooping cough and after immunization with a whole cell and an acellular pertussis vaccine. Int Arch Allergy Appl Immunol 1989; 89: 156-61; & Mark A, Bjorksten B, Granstrom M. Immunoglobulin E responses to diphtheria and tetanus toxoids after booster with aluminium-adsorbed and fluid DT vaccines. Vaccine 1995; 13: 669-73; & Mu HH, Sewell WA. Regulation of DTH and IgE responses by IL-4 and IFN-gamma in immunized mice given pertussis toxin. Immunology 1994; 83: 639-45; & Pauwels R, Van Der Straeten M, Platteau B, Bazin B. In vivo effects of Bordetella pertussis vaccine on IgE synthesis. Allergy 1983; 38: 239-46. ;& (d) Ryan M, Murphy G, Ryan E, et al. Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children. Immunology 1998; 93: 1-10; & (e) Shaheen SO, Aaby P, Hall AJ, et al. Measles and atopy in Guinea-Bissau. Lancet 1996; 347: 1792-6; & von Hertzen LC, Haahtela T. Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response? Am J Respir Cell Mol Biol 2000; 22: 139-42; & (f) Nilsson L, Kjellman NIM, Bjorksten B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med 1998; 152: 734-8; & Johnston IDA, Bland JM, Ingram D, Anderson HR, Warner JO, Lambert HP. Effect of whooping cough in infancy on subsequent lung function and bronchial reactivity. Am Rev Respir Dis 1986; 143: 270-5; & Wjst M, Dold S, Retmeir P, Fritzsch C, von Mutius E, Hiemann HH. Pertussis infection and allergic sensitisation. Ann Allergy 1994; 73: 450-4.
(6) Brasch J, Geier J, Schnuch A. Differentiated contact allergy lists serve in quality improvement. Hautarzt 1998; 49(3):1840
(7) Manzini BM, Ferdani G, Simonetti V, Donini M, Sedernari S. Contact sensitization in children. Pediatr Dermatol 1998; 15(1): 12-17; & Romaguera C, Vilaplana J. Contact dermatitis in children: 6 years experience. Contact Dermatitis 1998; 39(6): 277-80.
(8) Sun CC. Allergic contact dermatitis of the face from contact with nickel and ammoniated mercury. Contact Dermatitis 1987, 17(5):306-9.
(9) Xue C, He Z, Zhang H, Li S. Study on the contact allergen in patients with dermatitis and eczema. Wei Sheng Yen Chiu 1997, 26(5): 296-8.
(10) Aberer W, Holub H, Strohal R, Slavicek R. Palladium in dental alloys- the dermatologists responsibility to warn? Contact Dermatitis 1993. 28(3): 163-5.
(11) Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease. Stejskal V, Reynolds T, Bjorklund G. J Trace Elem Med Biol. 2015;31:230-6; & V.D.M. Stejskal, Dept. Of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden LYMPHOCYTE IMMUNO STIMULATION ASSAY MELISA � , paper presented at International Autism Conference, San Diego,2002 � www.melisa.org � & � Mercury-specific Lymphocytes: an indication of mercury allergy in man � , J. Of Clinical Immunology, 1996, Vol 16(1);31-40; see: www.melisa.org ; & Sterzl I, Prochazkova J, Stejaskal VDM et al, Mercury and nickel allergy: risk factors in fatigue and autoimmunity. Neuroendocrinology Letters 1999; 20:221-228; & V.Stejskal, � MELISA: A New Technology for Diagnosing and Monitoring of Metal Sensitivity � , Proceedings: 33rd Annual Meeting of American Academy of Environmental Medicine, Nov. 1998, Baltimore, Maryland.
(12) (a) Premature Puberty and Thimerosal-Containing Hepatitis B Vaccination : A Case-Control Study in the Vaccine Safety Datalink. � Geier DA, Kern JK, Geier MR. Toxics. 2018 Nov 15;6(4); & Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink. Geier DA, Young HA, Geier MR. Indian J Med Res. 2010 Apr;131: 500-7; & (b) A cross-sectional study of the relationship between infant Thimerosal-containing hepatitis B vaccine exposure and attention-deficit/hyperactivity disorder. Geier DA, Kern JK, et al; J Trace Elem Med Biol. 2018 Mar;46:1-9; & (c ) A Cross-Sectional Study of the Association between Infant Hepatitis B Vaccine Exposure in Boys and the Risk of Adverse Effects as Measured by Receipt of Special Education Services. Geier DA, Kern JK et al; Int J Environ Res Public Health. 2018 Jan 12;15(1); � & (d) Thimerosal-containing Hepatitis B Vaccine Exposure is Highly Associated with Childhood Obesity : A Case-control Study Using the Vaccine Safety Datalink. Geier DA, Sykes LK et al; N Am J Med Sci. 2016 Jul;8(7):297-306; & (e ) Thimerosal-Preserved Hepatitis B Vaccine and Hyperkinetic Syndrome of Childhood. Geier DA, Hooker BS, et al: Brain Sci. 2016 Mar 15;6(1); & (f) A longitudinal cohort study of the relationship between Thimerosal-containing hepatitis B vaccination and specific delays in development in the United States: Assessment of attributable risk and lifetime care costs. Geier DA, King PG, et al; J Epidemiol Glob Health. 2016 Jun;6(2):105-18; � Thimerosal-containing hepatitis B vaccination and the risk for diagnosed specific delays in development in the United States: a case-control study in the vaccine safety datalink. Geier DA, Hooker BS, et al; N Am J Med Sci. 2014 Oct;6(10):519-31; & (g) Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. Geier DA, Kern JK, Geier MR; J Trace Elem Med Biol. 2017 Jul;42:18-24.
(13) Redhe O, Pleva J. Recovery from asthma, allergies, ALS after removal of dental amalgam fillings. Int J of Risk & Safety in Medicine 1994; 4:229-236.
(14) Kurek M, Przybilla B, Hermann K, Ring J. An opioid peptide from cow � s milk, beta-casomorphine-7, is a direct histamine releaser in man. Int Arch Allergy immunol 1992; 97(2): 115-20.
(15) Tejwani GA, Hanissian SH. Modulation of mu, delta, and kappa opioid receptors in rat brain by metal ions and histidine. Neuropharmology 1990; 29(5): 445-52.
(16) Mondal MS, Mitra S. Inhibition of bovine xanthine oxidase activity by Hg2+ and other metal ions. J Inorg Biochem 1996; 62(4): 271-9; & Lead and mercury mutagenesis: Role of H 2 O 2 , superoxide dismutase, and xanthine oxidase, Maria E. Ariza, Gautam N. Bijur, Marshall V. Williams, Environ. Mol. Mutagen. 31:352-361, 1998; & Naidu BV, Fraga C, Salzman AL, Szab � C, Verrier ED, Mulligan MS. 2003. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. J Heart Lung Transplant 22:784-93; & Liaudet L, Szab � G, Szab � C. 2003. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite � PARP connection. Coronary Artery Dis. 14:115-122; & Naidu BV, Fraga C, Salzman AL, Szab � C, Verrier ED, Mulligan MS. 2003. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. J Heart Lung Transplant. 22: 784-93; & Vir � g L, Szab � E, Gergely P, Szab � C. 2003. Peroxynitrite- induced cytotoxicity: mechanisms and opportunities for intervention. Toxicology Letters 140:113-124;& Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Grisham MB, Hernandez LA, Granger DN. Am J Physiol. 1986 Oct;251(4 Pt 1):G567-74 http://www.inotekcorp.com/content/xo_inhibitors.asp
(17) Sastry KV, Gupta PK. In vitro inhibition of digestive enzymes by heavy metals and their reversal by chelating agents: Part 1, mercuric chloride intoxication. Bull Environ Contam Toxicol 1978; 20(6): 729-35; & W.Y.Boadi et al, Dept. Of Food Engineering and Biotechnology, T-I Inst of Tech., Haifa, Israel, � In vitro effect of mercury on enzyme activities � , Environ Res, 1992, 57(1):96-106; & Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT; Gastrointestinal abnormalities in children with autistic disorder. J Pediatr 1999, 135:559-63.
(18) Mc Fadden SA, Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways. Toxicology, 1996, 111(1-3):43-65; & Markovich et al, "Heavy metals (Hg,Cd) inhibit the activity of the liver and kidney sulfate transporter Sat 1", Toxicol Appl Pharmacol, 1999,154(2):181 7; & Matts RL, Schatz JR, Hurst R, Kagen R. Toxic heavy metal ions inhibit reduction of disulfide bonds. J Biol Chem 1991; 266(19): 12695-702; & T.L. Perry et al, � Hallevorden-Spatz Disease: cysteine accumulation and cysteine dioxygenase defieciency � , Ann Neural, 1985, 18(4):482-489; & Ceaurriz et al, Role of gamma glutamyltraspeptidase(GGC) and extracellular glutathione in disposition of inorganic mercury",J Appl Toxicol,1994, 14(3): 201
(19) (a) Shibuya-Saruta H, Kasahara Y, Hashimoto Y. Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties. J Clin Lab Anal. 1996;10(6):435-40; & Puschel G, Mentlein R, Heymann E, 'Isolation and characterization of dipeptidyl peptidase IV from human placenta', Eur J Biochem 1982 Aug;126(2):359-65; & Kar NC, Pearson CM. Dipeptyl Peptidases in human muscle disease. Clin Chim Acta 1978; 82(1-2): 185-92; & (b) Changes in the activities of some digestive enzymes , exposed chronically to mercuric chloride; Sastry KV, Gupta PK. J Environ Sci Health B. 1980;15(1):109-19 &(c ) Seroussi K, Autism and Pervasive Developmental Disorders , 1998, p174,etc., www.autismndi.com/ ; & (d)Blais A, Morvan-Baleynaud J, Friedlander G, Le Grimellec C. Primary culture of rabbit proximal tubules as a cellular model to study nephrotoxicity of xenobiotics. Kidney Int. 1993 Jul;44(1):13-8;
(20) Stefanovic V. et al, Kidney ectopeptidases in mercuric chloride-induced renal failure. Cell Physiol Biochem 1998; 8(5): 278-84.
(21) Crinnion WJ. Environmental toxins and their common health effects. Altern Med Rev 2000, 5(1):52-63.
(22) Immunological findings in autism. Int Rev Neurobiol. 2005;71:317-41, Cohly HH, Panja A; & (b) Effects of methyl mercury on cytokines, inflammation and virus clearance in a common infection (coxsackie B3 myocarditis). Toxicol Lett. 1996 Dec;89(1):19-28, Ilb � ck NG, Wessl � n L, Fohlman J, Friman G; & Trace element distribution in heart tissue sections studied by nuclear microscopy is changed in Coxsackie virus B3 myocarditis in methyl mercury-exposed mice. Biol Trace Elem Res. 2000 Winter;78(1-3):131-47, Ilb � ck NG, Lindh U, Wessl � n L, Fohlman J, Friman G; & (c) Assessment of mercury exposure and malaria in a Brazilian Amazon riverine community. Environ Res. 2002 Oct;90(2):69-75, Crompton P, Ventura AM, de Souza JM, Santos E, Strickland GT, Silbergeld E.
(23). Autism: a novel form of mercury poisoning. Med Hypotheses 2001 Apr;56(4):462-71, Bernard S, Enayati A, Redwood L, Roger H, Binstock T, www.autism.com/ari/mercurylong.html , � &(b)Dr. A Holmes, Autism Treatment Center,Baton Rouge, La; www.healing-arts.org/children/holmes.htm#wethink , &(c) Jaquelyn McCandless, M.D., Autism Spectrum Treatment Center, Woodland Hills, CA,&Jaquelyn McCandless, M.D, Children with Starving Brains, A Medical Treatment Guide for Autism Spectrum Disorder, 2003 www.autism rxguidebook.com/DesktopDefault.aspx?tabindex=11&tabid=15; � & (d) L. Redwood, Mercury and Autism, Vitamin Research News, May 2001, 15(5):1-12; &(e) Andrew H. Cutler, PhD, PE; Amalgam Illness: Diagnosis and Treatment ; 1996 , www.noamalgam.com/; &(f)Dr. R. Buttar, Autism, the Misdiagnosis of Our Future Generations, Congressional Testimony: Government Reform and Oversight Committee, U.S. House of Representatives, May 2004,
(24) Autism and schizophrenia linked to malfunctioning enzyme for milk protein digestion. Autism, Mar 1999, J.R. Cade et al; & Autism and Schizophrenia: Intestinal Disorders, Cade R et al. Nutritional Neuroscience, March 2000. http://www.feingold.org/Research/cade.html & http://www.paleodiet.com/autism/ ; & "Beta-casomorphin induces Fos-like immunoreactivity in discrete brain regions relevant to schizophrenia and autism" Autism March 1999 vol 3(1) 67-83; Sun, ZJ, Cade JR, et al & A Peptide Found in Schizophrenia and Autism Causes Behavioral Changes in Rats, J.R. Cade, Z. Sun , Univ of Florida, USA , Autism, Vol. 3, No. 1, 85-95 (1999) DOI: 10.1177/1362361399003001007 � 1999 The National Autistic Society, SAGE Publications http://aut.sagepub.com/cgi/content/abstract/3/1/85 ; & Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone, Leboyer M, et al., Encephale 1993 Mar-Apr;19(2):95-102; & Food allergy and infantile autism. Lucarelli S, et al., Panminerva Med 1995 Sep;37(3):137-41; http://www.feingold.org/Research/autism.html
& Application of the Exorphin Hypothesis to Attention Deficit Hyperactivity Disorder: A Theoretical Framework by Ronald Hoggan A Thesis Submitted To The Faculty Of Graduate Studies In Partial Fulfilment Of The Requirements For The Degree Of Master Of Arts, Graduate Division Of Educational Research,Calgary, April, 1998 University of Calgary
(25) Reichelt KL. Biochemistry and psycholphisiology of autistic syndromes. Tidsskr Nor Laegeforen 1994, 114(12):1432-4; & Reichelt KL et al, Biologically active peptide-containing fractions in schizophrenia and childhood autism. Adv Biochem Psychopharmocol 1981; 28: 627-43;&(b) Lucarelli S, Cardi E, et al, Food allergy and infantile autism. Panminerva Med 1995; 37(3):137-41; & (c) Shel L, Autistic disorder and the endogenous opioid system. Med Hypotheses 1997, 48(5):413-4;&(d) Beta-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development . Peptides. 2009 Jun 30. , Kost NV, Sokolov CO, et al.
(26) Huebner FR, Lieberman KW, Rubino RP, Wall JS. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Peptides 1984; 5(6):1139-47; & Wheat gluten as a pathogenic factor in schizophrenia. Singh MM, Kay SR, Science 1976 Jan 30;191(4225):401-2; & Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. Huebner FR,Lieberman KW, Rubino RP, Wall JS. Peptides. 1984 Nov-Dec;5(6):1139-47; & Naloxone antagonises effect of alpha-gliadin on leucocyte migration in patients with coeliac disease. Horv � th K, Gr � f L, Walcz E, Bod � nszky H, Schuler D. Lancet. 1985 Jul 27;2(8448):184-5; & www.flcv.com/autismgc.html
(27) Willemsen-Swinkels SH, Buitelaar JK, Weijnen FG, Thisjssen JH, Van Engeland H. Plasma beta-endorphin concentrations in people with learning disability and self-injurious and/or autistic behavior. Br J Psychiary 1996; 168(1): 105-9; & Leboyer M, Launay JM et al. Difference between plasma N- and C-terminally directed beta-endorphin immunoreactivity in infantile autism. Am J Psychiatry 1994; 151(12): 1797-1801.
(28) Scifo R, Marchetti B, et al. Opioid-immune interactions in autism: behavioral and immunological assessment during a double-blind treatment with naltexone. Ann Ist Super Sanita 1996; 32(3): 351-9.
(29) Eedy DJ, Burrows D, Dlifford T, Fay A. Elevated T cell subpopulations in dental students. J prosthet Dent 1990; 63(5):593-6; & Yonk LJ et al, CD+4 helper T-cell depression in autism. Immunol Lett, 1990, 25(4):341-5.
(30) Edelson SB, Cantor DS. Autism: xenobiotic influences. Toxicol Ind Health 1998; 14(4): 553-63; &
Liska, DJ. The detoxification enzyme systems. Altern Med Rev 1998. 3(3):187-98; & � HRI-Pfeiffer Center Autism Study; paper presented to Dan Conference, Jan 2001; www.hriptc.ort/Publish0900/index.html.
(31) Sayers LG; Brown GR; Michell RH; Michelangeli F. The effects of thimerosal on calcium uptake and inositol1,4,5 trisphosphate induced calcium release in cerebellar microsomes. Biochem J 1993 Feb 1;289 (Pt 3):883 7; & Toshiko Ueha-Ishibashi et al, Effect of thimerosal on intracellular Ca+ concentration of rat cerebellar neurons, Toxicology, 2004, 195:77-84; & Elferink JG. Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function modulating agent. Gen Pharmacol 1999 Jul;33(1):1 6
(32) (a) Lewis RN; Bowler K. Rat brain (Na+ K+) ATPase: modulation of its ouabain sensitive K+ PNPPase activity by thimerosal. Int J Biochem 1983;15(1):5 7; & (b)Anner BM, Moosmayer M. Mercury inhibits Na-K-ATPase primarily at the cytoplasmic side. Am J Physiol 1992; 262(5 Pt2):F84308; & (c) Effect of Chronic Exposure to Aluminum on Isoform Expression and Activity of Rat (Na + /K + )ATPase , Virg � lia S. Silva, Ana I. Duarte, A. Cristina Rego, Catarina R. Oliveira and Paula P. Gon � alves Toxicological Sciences 2005 88(2):485-494; & Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. Yokel RA. J Alzheimers Dis. 2006 Nov;10(2-3):223-53 & http://www.myflcv.com/vaxalum.html
(33) Halsey, NA. Limiting Infant Exposure to Thimerosal in vaccines. J. of the Amer. Medical Assoc., 282: 1763-66. Nov 1999.
(34) Wecker L, Miller SB, Cochran SR, Dugger DL, Johnson WD. Trace element concentrations in hair from autistic children. Defic Res 1985; 29(Pt 1): 15-22.
(35) Stejskal VDM, Danersund A, Lindvall A, Hudecek R, Nordman V, Yaqob A et al, Metal-specific memory lymphocytes: biomarkers of sensitivity in man. Neuroendocrinology Letters, 1999; & V.D.M.Stejskal et al, � Mercury-specific Lymphocytes: an indication of mercury allergy in man � , J. Of Clinical Immunology, 1996, Vol 16(1);31-40, & V.Stejskal, � MELISA: A New Technology for Diagnosing and Monitoring of Metal Sensitivity � , Proceedings: 33rd Annual Meeting of American Academy of Environmental Medicine, Nov. 1998, Baltimore, Maryland. See http://www.melisa.org ; & Two case reports from autism patients referred for MELISA testing (both reactive to thimerosal, etc.), http://www.melisa.org/case-reports/autism/
(36) Alberti A, Pirrone P, Elia M, Waring RH, Romano C. Sulphation deficit in � low-functioning � autistic children. Biol Psychiatry 1999, 46(3):420-4.
(37) (a)Wakefield A et al, Ileal-lymphoid-nodular hyperplasia and pervasive developmental disorder in children. Lancet 1998, 351(9103):637-41; & Kawashima H, Mori T, Kashiwagi Y, Takekuma K, Hoshika A, Wakefield A. Detection and sequencing of measles virus from peripheral mononuclear cells from patinets with inflamatory bowel and autism. Dig Dis Sci 2000 45(4):723-9; & Wakefield A et al, Inflammatory bowel disease syndrome and autism, Lancet, Feb 27, 2000;& Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders:Their Relationship to Gastrointestinal Symptoms and Dietary Intervention; Harumi Jyonouchi Lee Geng Agnes Ruby Barbie Zimmerman-Bier; Department of Pediatrics, New Jersey Medical School, UMDNJ, Newark, N.J. , USA , Neuropsychobiology 2005;51:77 � 85 & (b) Mercury and Autistic Gut Disease, McGinnis W.R., Environ Health Perspect. 2001 Jul;109(7):A303-4; http://findarticles.com/p/articles/mi_m0CYP/is_7_109/ai_78963514 & (c) G. Bell, Sterling Univ., Evidence of Toxic Metals/MMR connection in Autism, Autism Research Trust, 2002; & (92r,104); & (d ) Furlano RI, Anthony A, Day R, Brown A, McGarvey L, Thomson MA, Davies SE, Berelowitz M, Forbes A, Wakefield AJ, et al. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr 138:366-372 (2001); & (e) Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT. Gastrointestinal abnormalities in children with autistic disorder. J Pediatr 135:559-563 (1999).; & D'Eufemia P, Celli M, Finocchiaro R, Pacifico L, Viozzi L, Zaccagnini M, Cardi E, Giardini O. Abnormal intestinal permeability in children with autism. Acta Paediatr 85:1076-1079 (1996); & Goodwin MS, Cowen MA, Goodwin TC. Malabsorption and cerebral dysfunction: a multivariate and comparative study of autistic children. J Autism Child Schizophr 1:48-62 (1971) & http://www.autism.com/pdf/papers/Edelson_Paradiz.pdf
(38) B.J. Shenker et al, � Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes: Alterations in B-cell function and viability � Immunopharmacol Immunotoxicol, 1993, 15(1):87-112; & J.R.Daum, � Immunotoxicology of mercury and cadmium on B-lymphocytes � , Int J Immunopharmacol, 1993, 15(3):383-94.
(39) Pfieffer SI; Norton J; Nelson L; Shott S. Efficacy of vitamin B6 and magnesium in the treatment of autism. J Autism Dev Disord 1995 Oct;25(5):481 93; & Chuang D. Et al, National Institute of Mental Health, Science News, Nov 11, 2000, 158:309; & Lithium Protects Against Neuron Damage by Glutamate, Science News, 3-14-98, p164; & Moore G.J.et al, Lancet Oct 7, 2000; & Science News, 10-31-98, p276.
(40) Autism-Mercury@egroups.com, web group of parents with autistic kids and autism doctors and researchers; &(b)Dr. SB Edelson, http://www.edelsoncenter.com ; & � Eppright TD, Sanfacon JA, Horwitz EA. ADHD, infantile autism, and elevated blood-lead: a possible relationship. (case study) Mo Med 1996; 93(3):136-8.
(41) U.S. Environmental Protection Agency, Hazardous Air Pollutant Hazard Summary Fact Sheets , EPA: In Risk Information System, 2018; & EPA spokesman, U.S. News & World Report, In the Air that they Breathe, Science & News, 12-20-99. & U.S. Environmental Protection Agency (EPA), 2019, " Integrated Risk Information System , National Center for Environmental Assessment, Cincinnati, Ohio (& webpage); & Florida Department of Health, Bureau of Environmental Toxicology, Mercury Fish Advisory , 2020, & FFWGC, Health Advisories for Mercury in Florida Fish ; 2021; & United States Environmental Protection Agency, Office of Water, November 2000, The National Listing of Fish and Wildlife Advisories: Summary of 2020 Data , EPA ; & U.S. EPA, Office of Water, Mercury Update : Impact on Fish Advisories-Fact Sheet, http://www.epa.gov/ost/fish/mercury.html
(42) Stajich GV, Lopez GP, Harry SW, Sexson WR, Iatrogenic exposure to mercury after hepatitis B vaccination in preterm infants. Journal of Pediatrics, May 2000, 136(5):679-81; & (b) Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight; Hewitson L, et al. Neurotoxicology (2009), doi: 10.1016/
(43) Developing brain as a target of toxicity. Environ Health Perspect 1995; 103(Supp 6): 73-76, Rodier P.M.; & Critical Periods of Vulnerability for the Developing Nervous System: Evidence from human and animal models. Environ Health Persect 2000, 108(supp 3):511-533. Rice DC.
(44) The Center for Biologics Evaluation and Research (CBER), The US Food and Drug Administration (FDA), Jul 4, 2000.
(45) Grandjean P; Jurgensen PJ; Weihe P. Milk as a Source of Methylmercury Exposure in Infants. Milk as a Source of Methylmercury Exposure in Infants. Environ Health Perspect 1994 Jan;102(1):74 7.
(46) (a)Science News, Methylmercury � s toxic toll. July 29, 2000, Vol 158, No.5, p77; & National Research Council, Toxicological Effects of Methylmercury , National Academy Press, Wash, DC, 2000; & U.S. CDC, Second National Report on Human Exposure to Environmental Chemicals, www.cdc.gov/exposurereport/
& U.S. Centers for Disease Control, Mar 2001, Blood and Hair Mercury Levels in Young Children and Women of Childbearing Age, United States, 1999 www.cdc.gov/mmwr/preview/mmwrhtml/mm5008a2.htm ;
& (b)Grandjean P, 2000, Health effects of seafood contamination with methylmercury and PCBs in the Faroes. Atlantic Coast Contaminants Workshop, June 22-25, 2000, Bar Harbor Maine; & Environ Res, 1998; 77: 165-72
(47) Moreno-Fuenmayor H, Borjas L, Arrieta A, Valera V, Plasma excitatory amino acids in autism. Invest Clin 1996, 37(2):113-28; & Rolf LH, Haarman FY, Grotemeyer KH, Kehrer H. Serotonin and amino acid content in platelets of autistic children. Acta Psychiatr Scand 1993, 87(5): 312-6; & Naruse H, Hayashi T, Takesada M, Yamazaki K. Metabolic changes in aromatic amino acids and monoamines in infantile autism and a new related treatment, No To Hattatsu, 1989, 21(2):181-9; & Carlsson ML. Is infantile autsim a hypoglutamatergic disorer? J Neural Transm 1998, 105(4-5): 525-35.
(48) Reichrtova E et al, � Cord Serum Immunoglobulin E Related to Environmental Contamination of Human Placentas with Oganochlorine Compounds � , Envir Health Perspec, 1999, 107(11):895-99; & Gavett SH et al. Residual Oil Fly Ash Amplifies Allergic Cytokines, Airway Responsiveness, and Inflammation in Mice. Am J Respir Crit Care Med, 1999, 160(6):1897-1904; & Kramer U et al, Traffic-related air pollution is associated with atopy in children living in urban areas Epidemiology 2000, 11(1): 64-70.
(49) Megson MN, Is Autism A G Alpha Protein Defect Reversible with Natural Vitamin A? www.megson.com ; & (92d)
(50) B. Windham, Cognitive and Behavioral Effects of Toxic Metals, (over 150 medical study references) http://www.myflcv.com/tmlbn.html ; & (b)Prenatal and neonatal effects of mercury on infants, www.flcv.com/fetaln.html
(51) Walsh, WJ, Health Research Institute, Autism and Metal Metabolism,www.hriptc.org/autism.htm, Oct 20, 2000; & Walsh WJ, Pfeiffer Treatment Center, Metal Metabolism and Human Functioning, 2000, http://www.hriptc.org/content/behavioralDisorders.php
& HRI Pfeiffer Center Autism Study; paper presented to Dan Conference, Jan 2001; & Metal-Metabolism and Autism: Defective Functioning of Metallothionein Protein, Amy Holmes, MD; http://www.healing-arts.org/children/metal-metabolism.htm
(52) Dr. Gerald Bernstein, Beth Israel Medical Center, NY, past Pres., Amer. Diabetes Association; & U.S. Centers for Disease Control, 2001, www.mercola.com/2000/sept/17/diabetes_epidemic.htm; & Dr. Anthony Iacopino. Conference Paper, American Academy of Periodontology ; & (b) Diabetes: A Silent Epidemic, Newsweek, Sep 4, 2000; &(c) Dr. Bart Classen, Vaccines are the largest cause of insulin-dependent diabetes in young children, paper given at American College for Advancement in Medicine., Nashville, Tenn., May 14, 2001 ; & Classen B. ,Autoimmunity August 2002 Vol. 35 (4), pp. 247-253 & Swedish researchers, Ann. N.Y. Acad Sci. 958: 293-296, 2002; & (d)Harris Coulter, Childhood Vaccinations and Juvenile Onset (Type 1) Diabetes, Testimony before the Congress of the United States, House of Representatives, Committee on Appropriations, subcommittee on Labor, Health and Human Services, Education, and Related Agencies, April 16, 1997, www.909shot.com/hcdiabetes.htm & http://www.pnc.com.au/~cafmr/coulter/vacc-deb.html & (e) http://www.myflcv.com/diabetes.html
(53) Furlano RI, Anthony A, Day R, Murch SH, et al, Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr 138:366-72, 2001; & D � Eufemia P, Celli M, Giardini O, et al, Abnormal intestinal permeability in children with autism. Acta Paediatr 85:1076-9, 1996; & Goodwin MS, Cowen MA, Goodwin TC. Malabsorption and cerebral dysfunction: a multivariate and comparative sutudy of autistic children. J Austism Child Schizophr 1:48-52, 1971.
(54) Bamerjee S, Bhattacharya S. Histopathological changes induced by chronic nonlethal levels of mercury and ammonia in the small intestine of channa puntatus. Ecol Environ Safety 31:62-8 (1995); & Bohme M, Diener M, Mestres P, Rummel W. Direct and indirect actions of HgCl2 and methyl mercury chloride on permeability and chloride secretion across the rat colonic mucosa. Toxicol Appl Pharmacol 114:285-94 (1992); & Andres P. IgA-IgG disease in the intestine of Brown-Norway rats ingesting mercuric
chloride. Clin Immunol and Immunopath 30:488-494 (1984).
(55) Sasser LB, Jarboe GE, Walter BK, Kelman BJ. Absorption of mercury from ligated
segments of the rat gastrointestinal tract. Proc Soc Exp Biol Med 157:57-60 (1978).; & Kostial K, Kargacin B, Landeka M. Gut retention of metals in rats. Biol Trace Elem Res 21:213-218 (1989).
(56) Srikantaiah MV, Radhakrishnan AN. Studies on the metabolism of vitamin B6 in the
small intestine: Part III--purification and properties of monkey intestinal pyridoxal kinase. Indian J of Biochem 7:151-156 (1970).
(57) Chen W, Body RL, Mottet NK. Biochemical and morphological studies of monkeys chronically exposed to methylmercury. J Toxicol Environ Hlth 12:407-416 (1983).
(58) P.W. Mathieson, � Mercury: god of TH2 cells � ,1995, Clinical Exp Immunol
(59) Asthma, mercury, and vaccines. http://www.whale.to/vaccines/asthma.html
(60) Odent MR, Culpin EE, Kimmel T; Pertussis vaccination and asthma: is there a link? JAMA, 1994, 272:592-30; & (b) Dr. Julian Hopkn, Churchill Hospitial, Oxford, Asthma & allergy risk increased by vaccination, paper at meeting of British Thoriac Society, Dec 1997; & (c) Pertusiss vaccine associated with increased asthma and allergies, Archives of Pediatrics and Adoloescent Medicine, 1998; 152:734-738; & (d) Kozyrskyj et al, Univ. of Manitoba, U.S. Journal of Allergy and Clinical Immunology, Feb 2008
(61) Fine JM, Chen LC; � Confounding in studies of adverse reaction s to vaccines � , Amer J Epidemiology, 1992, 136: 121-35; & (b) Dr. Vera Scheibner, Leif Karlsson; � Association between DPT injections and Cot Death � , 2nd Immuniztion Conference, Canberra, Australia, May 27, 1991; & Vaccination: 100 Years of Orthodox Research , Dr.Viera Scheibner , http://www.shirleys-wellness-cafe.com/vaccine_sids.htm & (c)Torch WC, DPT Immunization: a potential cause of sudden enfant death syndrome(SIDS), Amer Acad of Neurology, 34th Annual Meeting, Apr 25, 1982; Neurology, 32(4), pt 2. http://thinktwice.com/sids.htm ; & (d) Raymond Obomsawin, M.D,. SIDS after DPT vaccinations in Japan , http://www.shirleys-wellness-cafe.com/vaccine_sids.htm , & V. Scheibner, http://www.whale.to/vaccines/scheibner1.html & (e) Vaccination Myths: by Alan Phillips, Director, Citizens for Healthcare Freedom http://www.mercola.com/2001/aug/18/vaccine_myths.htm ; & (f) SIDS - Do Vaccines Play a Role? D. Winkler, http://poisonevercure.150m.com/sids_vaccines_play_a_role.htm
& (g) Summary of Data in Vaccine Adverse Event Reporting System, Gannett News Service, http://www.vaccinationnews.com/DailyNews/December2001/FedClaimsCourtVax&SIDS.htm ; & (h) Vaccines & Sudden Infant Death- Analysis of VAERS database and medical literature- 1990-2019, https://pubmed.ncbi.nlm.nih.gov/34258234/
(62) Dr Thomas Verstraeten, US Centres for Disease Control and Prevention, Summary Results: Vaccine Safety Datalink Project a database of 400,000 children , May 2000.; & THE TRUTH BEHIND THE VACCINE COVER-UP, By Russell L. Blaylock, M.D. www.vran.org/vaccines/doctors/blaylock-covup.htm ; & (b) http://www.thinktwice.com/hepb.htm
(63) P. Bulat, � Activity of Gpx and SOD in workers occupationally exposed to mercury � , Arch Occup Environ Health, 1998, Sept, 71 Suppl: S37-9; & Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995; 18(2): 321-36.
(64) Spivey-Fox MR. Nutritional influences on metal toxicity. Environ Health Perspect 1979; 29: 95-104; & Pfeiffer SI et al, Efficacy of vitamin B6 and magnesium in the treatment of autism. J Autism Dev Disord 1995, 25(5):481-93.
(65) Hernberg S; & Moore MR. in Lead Toxicity, R.Singhal & J.Thomas(eds), Urban & Schwarzenberg, Inc. Baltimore, 1980; & Govani S, Memo M. � Chronic lead treatment differentially affects dopamine synthesis � , Toxicology 1979, 12:343-49; & Scheuhammer AM. Cherian MG. Effects of heavy metal cations and sulfhydyl reagents on striatal D2 dopamine receptors. Biochem Pharmacol 1985, 34(19):3405-13.
(66) Lars Landner and Lennart Lindestrom. Swedish Environmental Research Group(MFG), Copper in society and the Environment , 2nd revised edition. 1999.
(67) J.C.Veltman et al, "Alterations of heme, cytochrome P 450, and steroid metabolism by mercury in rat adrenal gland", Arch Biochem Biophys,1986, 248(2):467 78; & A.G.Riedl et al, Neurodegenerative Disease Research
Center, King's College,UK, "P450 and hemeoxygenase enzymes in the basal ganglia and their role's in Parkinson's disease", Adv Neurol, 1999; 80:271 86
(68) Mata L, Sanchez L, Calvo M, Interaction of mercury with human and bovine milk proteins. Biosci Biotechnol Biochem 1997 Oct;61(10):1641 5; & Kostial K, Rabar I, Ciganovic M, Simonovic I, Effect of milk on mercury absorption and gut retention in rats. Bull Environ Contam Toxicol 1979, Nov;23(4 5) :566 7; & Rowland IR, Robinson RD, Doherty RA, Effects of diet on mercury metabolism and excretion in mice given methylmercury: role of gut flora, Arch Environ Health 1984 Nov Dec;39(6):401 8
(69) E.Lutz et al, Concentrations of mercury in brain and kidney of fetuses and infants, Journal of Trace Elements in Medicine and Biology, 1996,10:61-67; & G.Drasch et al, Mercury Burden of Human Fetal and Infant Tissues, Eur J Pediatr 153:607-610,1994; &(b) A.Oskarsson et al, Mercury in breast milk in relation to fish consumption and amalgam, Arch environ Health, 1996,51(3):234-41; & (c)Drasch et al, Mercury in human colostrum and early breast milk, J.Trace Elem. Med.Biol., 1998,12:23-27; & (d ) Concentration of mercury, cadmium, and lead in breast milk from Norwegian mothers: Association with dietary habits, amalgam and other factors, Science of the Total Environment , Volume 677 , 10 August 2019, Pages 466-473.
(70) Kravchenko AT, Dzagurov SG, Chervonskaia GP. III. The detection of toxic properties in medical biological preparations by the degree of cell damage in the L132 continuous cell line. Zh Mikrobiol Epidemiol Immunobiol 1983 Mar;(3):87 92 [Article in Russian]
(71) The Health of Canada's Children, A Canadian Institute of Child Health (CICH), Profile: 3rd Edition, 2000, 325 pages; http://oncology.medscape.com/26856.rhtml
(72) (a) HultmanP, Johansson U, Turley SJ; Adverse immunological effects and autoimmunity induced by dental amalgam in mice. FASEB J 1994; 8: 1183-90; &.(b) Pollard KM, Lee DK, Casiano CA; The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular structure ad antigenic properties. J Immunol 1997; 158: 3421-8; &(c) P.L.Bigazzi, Autoimmunity induced by metals, in Chang, L., Toxicology of Metals , Lewis Publishers, CRC Press Inc. 1996., p835-52; & (d) Hu H; Moller G; Abedi Valugerdi M. Major histocompatibility complex class II antigens are required for both cytokine production and proliferation induced by mercuric chloride in vitro. J Autoimmun 1997 Oct;10(5):441 6;
(73) (a)C.J.G.Robinson et al, � Mercuric chloride induced anitnuclear antibodies In mice � , Toxic Appl Pharmacology, 1986, 86:159-169. & (b) El-Fawai HA, Waterman SJ, De Feo A, Shamy MY. Neuroimmunotoxicology: Humoral Assessment of Neurotoxicity and Autoimmune Mechanisms. Contact Dermatitis 1999; 41(1): 60-1;
& (c) Hu H; Moller G; Abedi Valugerdi M. Mechanism of mercury induced autoimmunity: both T helper 1 and T helper 2 type responses are involved. Immunology 1999 Mar;96(3):348 57;
(74) Earl C, Chantry A, Mohammad N. Zinc ions stabilize the association of basic protein with brain myelin membranes. J Neurochem 1988; 51:718-24; & Ricco P, Giovanneli S, Bobba A. Specificity of zinc binding to myelin basic protein. Neurochem Res 1995; 20:1107-13.
(75) (a)The extent of drug therapy for attention deficit-hyperactivity disorder among children in public schools. (American Journal of Public Health. 1999; 89(9):1359-64); & www.niehs.hih.gov/oc/news.adhd.htm
& (b) Science News, Vol 158, Oct 14, 2000
(76) Adverse health effects of Ritalin and other stimulant drugs: http://users.cybercity.dk/~bbb9582/ritalin.htm; & www.healthysource.com/ritalin.html; & www.breggin.com/RitalinNIHSPEECH.html; &
www.healthoptions.com/ritalin.html; & http://lifefellowship.org/ Updatables/Articles/40.html;
Michael R. Lyon, Healing the Hyperactive Brain through the Science of Functional Medicine , www.pureliving.com/product.html
(77) Omura, Yoshiaki; Abnormal Deposits of Al, Pb, and Hg in the Brain, Particularly in the Hippocampus, as One of the Main Causes of Decreased Cerebral Acetylcholine, Electromagnetic Field Hypersensitivity, Pre-Alzheimer's Disease, and Autism in Children; Acupuncture & Electro-Therapeutics Research, 2000, Vol. 25 Issue 3/4, p230, 3p
(78) Razagui IB, Haswell SJ; . Mercury and selenium concentrations in maternal and neonatal scalp hair: relationship to amalgam-based dental treatment received during pregnancy. Biol Trace Elem Res 2001 Jul;81(1):1-19; & Cernichiari E, Brewer R, Myers GJ, Marsh DO, Berlin M, Clarkson TW; Monitoring methyl mercury during pregnancy: maternal hair predicts fetal brain exposure. Neurotoxicology 1995 Winter;16(4):729005 10:
(79) Magos L, Brown AW, Sparrow S, Bailey E, Snowden RT, Skipp WR; The comparative toxicology of ethyl- and methylmercury; Arch Toxicol 1985 Sep;57(4):260-7; & Suda I, Totoki S, Uchida T, Takahashi H. Degradation of methyl and ethyl mercury into inorganic mercury by various phagocytic cells; Arch Toxicol 1992;66(1):40-4.
Abnormal Brain Connectivity Spectrum Disorders Following Thimerosal Administration: A Prospective Longitudinal Case-Control Assessment of Medical Records in the Vaccine Safety Datalink. Geier DA, Homme KG, et al;
2017 Mar 16;15(1):1559325817690849.; & (b )
Thimerosal exposure and disturbance of emotions specific to childhood and adolescence: A case-control study in the Vaccine Safety Datalink (VSD) database. Geier DA, Kern JK et al;
2017;31(2): 272-278; & (c)
Neurodevelopmental disorders following thimerosal-containing vaccines. Ex Biol Med, April 2003, Geier M.R., Geier DA; & (d)
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. Geier DA, Sykes LK, et al;
2015 Jun;8(2):68-76; & (e)
A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders. Geier DA, Hooker BS et al;
Int J Environ Res Public Health.
2014 Sep 5;11(9): 9156-70; & (f)
A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States. Geier DA, Hooker BS et al;
2013 Dec 19;2(1):25; & (g) Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the Vaccine Safety Datalink. Young HA, Geier DA, et al;
J Neurol Sci.
2008 Aug 15;271(1-2):110-8; & (h)
A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: a follow-up analysis. Geier DA, Geier MR.
Med Sci Monit. 2005 Apr;11(4):CR160-70; & (J) Neurodevelopmental disorders following thimerosal-containing childhood immunizations: a follow-up analysis. Geier DA, Geier MR. Int J Toxicol. 2004 Nov-Dec;23(6):369-76.
(81) Thimerosal in Childhood Vaccines, Neurodevelopmental Disorders, and Heart Disease in the U.S. ; J of Amer Physicians and Surgeons, Vol 8(1), Spring 2003, Geier M.R., Geier DA; & (b) Bradstreet J, Geier DA, et al, A case control study of mercury burden in children with Autisitic Spectrum Disorders, J of Amer Physicians and Surgeons, Vol 8(3), Summer 2003; & (c) A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders. Geier DA, Geier MR. J Toxicol Environ Health A. 2007 May 15;70(10):837-51; & (d) Stratton KR, et al. Adverse events associated with childhood vaccines. Evidence bearing on causality. IOM. National Academy Press. Washington, DC 1994.
(82) American Academy of Dermatology, Press Release, Feb 2000; &(b) NIAMS, http://wrongdiagnosis.com/e/eczema/prevalence.htm , & � B.Windham, Immune Reactive Conditions: The mercury connection to eczema, lupus, asthma, and allergies, www.flcv.com/immunere.html
(83) Voices of Safety International, Standard for Correct Birthing Procedure in Order to Ensure Neurological Viability, http://cordclamping.com
(84) (a) P.K. Pang et. al., J. of Hypertension 1996; 14: 1053-1060 ; & (b)C. Benishen, Journal of Cardiovasc. Pharm 1994; 23(S2):S1-S8; & (c) A. Szucs et. al, Effects of inorganic mercury and methylmercury on the ionic currents of cultured rat hippocampal neurons. Cell Mol. Neruobiol 1997; 17(3): 273-282; & (d)D.R. Storm et. al, Nature 1974; 250: 778-779; & (e) A. Badou et. al., HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent calcium influx through L-type calcium channels.
J. Biol Chem 1997; 272(51): 32411-8.
(85) D. Klinghardt (MD), � Migraines, Seizures, and Mercury Toxicity � , Future Medicine Publishing, 1997; & Szasz A, Barna B, Gajda Z, Galbacs G, Kirsch-Volders M, Szente M. Effects of continuous low-dose exposure to organic and inorganic mercury during development on epileptogenicity in rats.Neurotoxicology. 2002 Jul;23(2):197-206. firstname.lastname@example.org , & www.flcv.com/epilepsy.html
(86) A.S. Holmes, M.F. Blaxill and B.E. Haley, Reduced Levels of Mercury in First Baby Haircuts of Autistic Children; International Journal of Toxicology, 2003, & Baby hair, mercury toxicity and autism. Int J Toxicol. 2004 Jul-Aug;23(4):275-6. Grether J, Croen L, Theis C, Blaxill M, Haley B, Holmes A. www.ncbi.nlm.nih.gov/pubmed/12933322?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
(87) Amer. College of Medical Genetics Working Group on ApoE and Alzheimer � s Disease, JAMA, 1995, 274: 1627-29; & Mercury toxicity presenting as chronic fatigue, memory impairment and depression: diagnosis, treatment, susceptibility, and outcomes in a New Zealand general practice setting (1994-2006). Wojcik DP, Godfrey ME, Haley BE. � Neuro Endocrinol Lett. 2006 Aug;27(4):415-23; & � Godfrey ME, Wojcik DP, Krone CA. Apolipoprotein E genotyping as a potential biomarker for mercury neurotoxicity. J Alzheimers Dis. 2003 Jun;5(3):189-95.
(88) Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Waly M, Olteanu H, Banerjee R, et al. Mol Psychiatry. 2004 Apr;9(4):358-70 ; & (b) Mercury and autism: accelerating evidence? Mutter J, Naumann J, Schneider R, Walach H, Haley B. Neuro Endocrinol Lett. 2005 Oct;26(5):439-46; & � Hornig M, Chian D, Lipkin WI., Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry. 2004 Jun 8; & (d) The relationship between mercury and autism: A comprehensive review and discussion. Kern JK, Geier DA, et al; J Trace Elem Med Biol. 2016 Sep;37: 8-24. ; &(e ) Background lead and mercury exposures: Psychological and behavioral problems in children. Gump BB, Dykas MJ, et al; Environ Res. 2017 Oct;158: 576-582.
(89)Makani A, Gollapudi S, Yel L, Chiplunkar S, Gupta S; Biochemical and molecular basis for thimerosal-induced apoptosi in T-cells; a major role of mitochondrial pathway; Genes and Immunity, 2002, 3:270-278; & (b) James S.J., Slikker W, Melnyk S, New E, Pogribna M, Jernigan S; Thimerosal neurotoxicity is associated with glutathione depletion: Protection with nutritional supplementation; Dept. of Pediatrics, College of Medicine, Univ. of Arkansas, and Arkansas Children � s Hospital Reserch Institute, Little Rock, Ark; Neurotoxicology Conference, Hawaii, February 2004
(90) Mercury, lead, and zinc in baby teeth of children with autism versus controls, Adams JB, Romdalvik J, Ramanujam VM, Legator MS. J Toxicol Environ Health A. 2007 Jun;70(12):1046-51
(91) A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. Geier DA, Geier MR. J Toxicol Environ Health ,Part A. 2007 Oct;70(20):1723-30; & A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Geier DA, Geier MR. Neurotox Res. 2006 Aug;10(1):57-64 www.flcv.com/autismhg.html
(92) Evidence that vaccine risk is higher than benefits: summary, www.flcv.com/vaxharm.html ; & (b) Relation of beta-casomorphin to apnea in sudden infant death syndrome; Sun Z, Zhang Z, et al, Peptides. 2003 Jun;24(6):937-43
(93) Vaccinated Children Two and a Half Times More Likely to Have Neurological Disorders than unvaccinated children www.generationrescue.org/survey.html Jun 26, 2007; & http://www.generationrescue.org/olmstead.html
( 94) Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas, Health and Place, R.F. Palmer et al, March 2005 http://www.generationrescue.org/pdf/seed.pdf & Mercury pollution from power plants, NWF, http://www.nwf.org/wildlife/pdfs/MercuryMythsFacts.pdf
& (b) Mental retardation and prenatal methylmercury toxicity., Trasande L, Schechter CB, Haynes KA, Landrigan PJ., Department of Community and Preventive Medicine, Center for Children's Health and the Environment, New York, New York. Am J Ind Med. 2006 Mar;49(3):153-8, http://www.melisa.org/abstracts.php#1
(95) Dental amalgam is the largest source of mercury in sewers and a significant source of mercury in water bodies, fish, and the environment, www.flcv.com/damspr2f.html
(96) (a) Developmental neurotoxicants and the vulnerable male brain : a systematic review of suspected neurotoxicants that disproportionally affect males. Kern JK, Geier DA, et al; Acta Neurobiol Exp (Wars). 2017;77(4):269-296; &
A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders. Geier DA, Geier MR. Neuro Endocrinol Lett. 2006 Dec;27(6):833-8; & A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Geier DA, Geier MR. Neuro Endocrinol Lett. 2007 Oct;28(5):565- 73 www.flcv.com/autismhg.html
(97) (a) Altered vascular phenotype in autism: correlation with oxidative stress. Yao Y, Walsh WJ, McGinnis WR, Pratic � D. Arch Neurol. 2006 Aug;63(8):1161-4 & (b)Oxidative stress in autism. McGinnis WR. Altern Ther Health Med. 2004 Nov-Dec;10(6):22-36; quiz 37, 92. & (c)McGinnis WR. Oxidative stress in autism. Altern Ther Health Med. 2005 Jan-Feb;11(1):19; & (d)Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism S Jill James, Paul Cutler, Stepan Melnyk, Stefanie Jernigan, Laurette Janak, David W Gaylor, and James A Neubrander. Am J Clin Nutr 2004;80: 1611 � 7; & (e)Oxidative stress in autism, Abha Chauhan and Ved Chauhan a , Pathophysiology, Volume 13, Issue 3, August 2006, Pages 171-181
(98) Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. Vojdani A, Pangborn JB, et al, Int J Immunopathol Pharmacol. 2003 Sep-Dec;16(3):189-99 ; & (b) Autism and Lyme Disease Connection, Robert Bransfield, M.D. , et al, Medical Hypothesis, Jul 2008; & Duncan and Rosner, The Lyme-Autism Connection , 2008;
(99) Kozyrskyj et al, Univ. of Manitoba, U.S. Journal of Allergy and Clinical Immunology, Feb 2008, & Winnipeg Free Press Jan. 25, 2008.
(100) (a) Parent Ratings of Behavioral Effects of Biomedical Interventions for large group of parents of children who had autism , www.autism.com/pdf/providers/ParentRatings2009.pdf
& (b) Parent Ratings of Behavioral Effects of Biomedical Interventions for Asperger Syndrome http://www.autism.com/treatable/form34qraspergersyndrome.htm : & (c) Autism, an extreme challenge to integrative medicine. Part 2: medical management; Kidd PM. Altern Med Rev. 2002 Dec;7(6):472-99
(101) Amy Holmes, MD, Healing Arts Center, www.flcv.com/autismc.html; & Recovering From Autism: A Local Florida Doctor Says It's Possible Using Metals Detoxification Protocol, By Patricia Crosby First Coast News January 22, 2007, www.firstcoastnews.com/news/local/news-article.aspx?storyid=74021 & www.jacksonville.com/tu-online/stories/121807/met_226363926.shtml ; & Pediatrician David Berger, MD." https://wholisticfamilycare.com/about-us/meet-dr-david/ ; & Mother helps child battle autism , Chelation Protocol and nutritional measures bring daughter back from autism to A student in school, January 13, 2008
(102) Blood Levels of Mercury Are Related to Diagnosis of Autism, Desoto MC, Hitlan RT Journal of Child Neurology, Vol. 22, No. 11, 1308-1311 (2007); & &(f) LOVE LETTERS from the Autism-Mercury list ;
(103) Mercury on the Mind, by Donald W. Miller, Jr., MD , Washington Univ. Medical School, 2018, http://www.doctorsaredangerous.com/articles/mercury.htm
(104) Auto-Immunity, Vaccines and Autism, Lewis Mehl-Madrona, M.D., Ph.D., Beth Israel Hospital / Albert Einstein School of Medicine, http://www.healing-arts.org/children/vaccines/vaccines-auto-immunity.htm#auto; & Vaccine Induced Demyelination, www.healing-arts.org/children/vaccines/vaccines-demyelination.htm
(105) Polymorphism of bovine beta-casein and its potential effect on human health, J
Appl Genet 48(3), 2007, pp. 189 � 198, Stanis � aw Kami � ski1, Anna Cieoeli � ska1, El � bieta Kostyra2; & (b)Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption. Diabetologia 1999 Aug;42(8):1032; Elliott RB, Harris DP, Hill JP, Bibby NJ, Wasmuth HE ; &(c) Sokolov OIu, Kost NV et al, [Regulatory peptides and psychomotor development in infants], Vestn Ross Akad Med Nauk. 2007;(3):33-9 & Influence of human B-casomorphin-7 on specific binding of 3H-spiperone to the 5-HT2-receptors of rat brain frontal cortex; Protein Pept Lett. 2006;13(2):169-70; & (d) Dubynin VA, Malinovskaia IV, et al; Delayed effect of exorphins on learning of albino rat pups], [Article in Russian] Izv Akad Nauk Ser Biol. 2008 Jan-Feb;(1):53-60; & (e) Findings in normal rats following administration of gliadorphin-7 (GD-7) Sun Z, Cade R. Peptides. 2003 Feb;24(2):321-3
(106) (a) Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. Rom � n GC. J Neurol Sci. 2007 Nov 15;262(1-2):15-26; & (b) Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice. Toxicology. 2007 Oct 8;239(3):195-203. Epub 2007 Jul 13 ; Carvalho MC, Franco JL, Ghizoni H, Kobus K, Nazari EM, Rocha JB, Nogueira CW, Dafre AL, M � ller YM, Farina M; & (c) Pathological changes in the Brown Norway rat cerebellum after mercury vapour exposure. Toxicology. 1995 Dec 15;104(1-3):83-90. Hua J, Brun A, Berlin M, & http://www.myflcv.com/endohg.html
(107) Thyroid malfunction in women; Ginecol Obstet Mex. 2001 May; 69:200-5, Z � rate A, Basurto L, Hern � ndez M; & (b) Clinical controversies in screening women for thyroid disorders during pregnancy. Wier FA, Farley CL. J Midwifery Womens Health. 2006 May-Jun;51(3):152-8.
(108) Postpartum thyroiditis. Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):303-16. Stagnaro-Green A; & Recognizing, understanding, and treating postpartum thyroiditis. Endocrinol Metab Clin North Am. 2000 Jun;29(2):417-30, ix. Stagnaro-Green A; & (b) Postpartum depression and thyroid antibody status. Thyroid. 1999, 9(7):699-703, Harris B
(109) Some neurologic and psychiatric complications in endocrine disorders: the thyroid gland, [Article in Hungarian] Aszal � s Z. Orv Hetil. 2007 Feb 18;148(7):303-10; &(b) Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics. 2006 Jan;117(1):161-7. Kooistra L, Crawford S, van Baar AL, Brouwers EP, Pop VJ; & (c) Hypothyroidism and pregnancy: impact on mother and child health.] Ann Biol Clin (Paris). 2008 Jan 29;66(1):43-51, [Article in French], Menif O, Omar S, Feki M, Kaabachi N.
(110) Chelation: The Real Story Behind the Misleading Headlines Autism Research Review International, 2005, Vol. 19, No. 3, page 3, 3 & www.autism.com/pdf/providers/ParentRatings2009.pdf ; & Autism Treatment using Chelation/DMSA, BMC Clinical Pharmacology, Oct 2009, www.generationrescue.org/recovery & www.healing-arts.org/children/holmes.htm
(111) Neuropsychiatric aspects of hypothyroidism and treatment reversibility. Minerva Endocrine. 2007 Mar;32(1):49-65, Davis JD,Tremont G; & (b) Subclinical hypothyroidism: psychiatric disorders and symptoms. Rev Bras Psiquiatr. 2007 Jun;29(2):157-9 , Almeida C, Brasil MA, Costa AJ et al.
(112) Singh VK; Lin SX; Yang VC. Serological association of measles virus and
human herpesvirus 6 with brain autoantibodies in autism. Clin Immunol Immunopathol 1998 Oct;89(1):105 8; http://articles.mercola.com/sites/articles/archive/2000/04/16/congressional-autism-testimony.aspx#commentfocus
(113) (a) The Third National Health and Nutrition Examination Survey (NHANES III) , & (b) Archives of Internal Medicine, Feb 28, 2000, Chester Ridgway, MD, head of the Division of Endocrinology at the University of Colorado Health Sciences Center.
(114) (a) Mercury burden of human fetal and infant tissues. Drasch G, Schupp I, H � fl H, Reinke R, Roider G. Eur J Pediatr. 1994 Aug;153(8):607-10; & (b ) Dental amalgam and mercury levels in autopsy tissues: food for thought. Guzzi G, Grandi M, Severi G et al. Am J Forensic Med Pathol. 2006 Mar;27(1):42-5
(115) LDN for MS Trials/Experience http://www.ldnresearchtrust.org/default.asp?page_id=77
(119) (a) Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study. Environ Health. 2007 Oct 11;6:30, Bj � rkman L, Lundekvam BF, Vahter M,
(120) (a) Vimy MJ, Takahashi,Y, Lorscheider FL; Maternal Fetal Distribution of Mercury Released From Dental Amalgam Fillings. Dept of Medicine and Medical Physiology , faculty of Medicine, Univ. of Calgary, Calgary Alberta Canada, Amer.J.Physiol.,1990, 258:R939-945; & (b) Hahn LJ, Kloiber R, Leininger RW, Vimy MJ, Lorscheider FL. Distribution of mercury released from amalgam fillings into monkey tissues � , FASEB J.,1990, 4:5536; & (c) Mercury from maternal "silver" tooth fillings in sheep and human breast milk. A source of neonatal exposure. Vimy MJ, Hooper DE, King WW, Lorscheider FL. Biol Trace Elem Res. 1997 Feb;56(2):143-52
122. Oskarsson A, Schultz A, Skerfving S, Hallen IP, Ohlin B, Lagerkvist BJ. Mercury in breast milk in relation to fish consumption and amalgam. Arch Environ Health, 1996,51(3):234 41;&(b) Drasch G, Aigner S, Roider G, Staiger F, Lipowsky G. Mercury in human colostrum and early breast milk. J Trace Elem Med Biol 1998; 12:23 27; &(c) Paccagnella B, Riolfatti M. Total mercury levels in human milk from Italian mothers. Ann Ig 1989: 1(3-4):661-71;
123. Yang J, Jiang Z,Wang Y, Qureshi IA, Wu XD. Maternal fetal transfer of metallic mercury via placenta and milk. Ann Clin Lab Sci 1997; 27(2):135 141; & (b) Soong YK, Tseng R, Liu C, Lin PW. J of Formosa Medical Assoc 1991; 90(1): 59 65; & (c ) Sundberg J, Ersson B, Lonnerdal B, Oskarsson A. Protein binding of mercury in milk and plasma from mice and man a comparison between methylmercury and inorganic mercury. Toxicology 1999 Oct 1;137(3):169 84.
124. Kuhnert PM, Kuhnert BR, Erhard P. Comparison of mercury levels in maternal blood, fetal blood, fetal cord blood, and placental tissues. Am J Obstet Gynecol, 1981, 139(2): 209-13, & Vahter M, Akesson A, Lind B, Bjors U, Schutz A, Berglund M, "Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood", Environ Res 2000 Oct;84(2):186-94; & Kuntz WD, Pitkin RM, Bostrom AW, Hughes MS. Maternal and chord blood mercury background levels; a longitudinal surveillance. Am J Obstet and Gynecol 1982; 143(4): 440 443.
125. Ramirez GB, Cruz MC, Pagulayan O, Ostrea E, Dalisay C. The Tagum study I: analysis and clinical correlates of mercury in maternal and cord blood, breast milk, meconium, and infants' hair. Pediatrics 2000 Oct;106(4):774 81; & (b) Ramirez GB, Pagulayan O, Akagi H, Francisco Rivera A, Lee LV, Berroya A, Vince Cruz MC, Casintahan D. Tagum study II: follow-up study at two years of age after prenatal exposure to mercury. Pediatrics. 2003 Mar;111(3):e289-95; &(c) Warfvinge K, Berlin M, Logdberg B. The effect on pregnancy outcome and fetal brain development of prenatal exposure to mercury vapour. Neurotoxicology 1994; 15(4).
126. Drexler H, Schaller KH. The mercury concentration in breast milk resulting from amalgam
fillings and dietary habits. Environ Res 1998; 77(2): 124-9.
127. Mottet NK, Shaw CM, Burbacher, TM, Health Risks from Increases in Methylmercury Exposure, Health Perspect 1985; 63: 133 140; & (b) P.Grandjean et al, � MeHg and neurotoxicity in children � , Am J Epidemiol, 1999; & Sorensen N, et al; Prenatal mercury exposure raises blood pressure, Epidemiology 1999, 10:370-375; & Grandjean P; Jurgensen
(129) (a) L. Ronnback et al, "Chronic encephalopaties induced by low doses of mercury or lead", Br J Ind Med 49: 233-240, 1992; &(b) Langauer-Lewowicka H. [Chronic toxic encephalopathies] [Polish] Med Pr. 1982;33(1-3):113-7;
CDC Head admits that vaccines can cause autism,
Survey: Children of most pregnant women who got flu shot are unhealthy,
http://adventuresinautism.blogspot.com/2006/01/did-you-get-flu-shot-while-pregnant.html ; & Gov't: Girl � s Autism-Like Symptoms Linked to Vaccines,
(132) (5) Understanding Nutrition, 11 th Edition; E. Whitney, S.R. Rolfes, Wadsworth Cengage Learning, 2008, p 110,111, etc.
(133) Treatment of Autism Options: www.generationrescue.org/recovery &
(135) Huggins HA, Levy,TE, Uniformed Consent: the hidden dangers in dental care , 1999,
(137) A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Med Sci Monit. 2004 Mar;10(3): PI33-9; Geier DA, Geier MR.
(138) Neurodevelopmental Disorders, Maternal Rh-Negativity, and Rho(D) Immune Globulins:A Multi-Center Assessment, Neuroendocrinology Letters Volume 29 No. 2 2008, D.A. Geier, M.R. Geier, et al,
(139) Fetal and postnatal metal dysregulation in autism. Arora M, Reichenberg A, et al; Nat Commun. 2017 Jun 1;8:15493.
Nat Commun. 2017 Jun 1;8:15493.
(140) The risk of neurodevelopmental disorders following Thimerosal-containing Hib vaccine in comparison to Thimerosal-free Hib vaccine administered from 1995 to 1999 in the United States. Geier DA, Kern JK et al; Int J Hyg Environ Health. 2018 May;221(4):677-683; & (b) � A case-control study evaluating the relationship between thimerosal-containing haemophilus influenzae type b vaccine administration and the risk for a pervasive developmental disorder diagnosis in the United States. Geier DA, Kern JK et al; Biol Trace Elem Res. 2015 Feb;163(1-2):28-38.
(141) An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States. Geier DA, Geier MR.
(142) A Two-Phase Case-Control Study of Autism Risk Among Children Born From the Late 1990s Through the Early 2000s in the United States. Geier DA, Kern JK, Geier MR. Med Sci Monit. 2016 Dec 29;22:5196-5202; & A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States. Geier DA, Geier MR. Geier DA, Geier MR. Neuro Endocrinol Lett. 2006 Aug;27(4):401-13; & An assessment of downward trends in neurodevelopmental disorders in the United States following removal of Thimerosal from childhood vaccines. Geier DA, Geier MR. Med Sci Monit. 2006 Jun;12(6):CR231-9.
(143) (a)Knapp LT; Klann E. Superoxide induced stimulation of protein kinase C via thiol modification and modulation of zinc
content. J Biol Chem 2000 May 22; & (b) B.Rajanna et al, � Modulation of protein kinase C by heavy metals � , Toxicol Lett,
(144) Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism. Kern JK, Haley BE, et al; Int J Environ Res Public Health. 2013 Aug 20;10(8):3771-800; & (b) The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists. Geier DA, Kern JK, Geier MR, Acta Neurobiol Exp (Wars). 2010;70(2):209-26.
(145) Thimerosal: clinical, epidemiologic and biochemical studies. Geier DA, King PG, et al; Clin Chim Acta. 2015 Apr 15;444:212-20, & (b) A review of Thimerosal (Merthiolate) and its ethylmercury breakdown product: specific historical considerations regarding safety and effectiveness. Geier DA, Sykes LK et al; J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):575-96. � & The relative toxicity of compounds used as preservatives in vaccines and biologics. Geier DA, Jordan SK et al; Med Sci Monit. 2010 May;16(5):SR21-7.
(146) Thimerosal as discrimination: vaccine disparity in the UN Minamata Convention on mercury. Sykes LK Geier DA, King PG, et al; Indian J Med Ethics. 2014 Oct-Dec;11(4):206-18.
(147) Methodological issues and evidence of malfeasance in research purporting to show thimerosal in vaccines is safe. Hooker B, Kern J, et al; Biomed Res Int. 2014: 247218.
(150) (a)Sin YM, Teh WF, Wong MK, Reddy PK - "Effect of Mercury on Glutathione and Thyroid Hormones" Bulletin of Environmental Contamination and Toxicology 44(4):616-622 (1990); & (b)J.Kawada et al, � Effects of inorganic and methyl mercury on thyroidal function � , J Pharmacobiodyn, 1980, 3(3):149-59; &(c) Ghosh N. Thyrotoxicity of cadmium and mercury. Biomed Environ Sci 1992, 5(3): 236-40; & (d) Kabuto M - "Chronic effects of methylmercury on the urinary excretion of catecholamines and their responses to hypoglycemic stress" Arch Toxicol 65(2):164-7 (1991)
(155) Role of reactive oxygen species and glutathione in inorganic mercury-induced injury in human glioma cells. Neurochem Res. 2001 Nov;26(11):1187-93, Lee YW, Ha MS, Kim YK; & Sin YM, Teh WF, Wong MK, Reddy PK - "Effect of Mercury on Glutathione and Thyroid Hormones" Bulletin of Environmental Contamination and Toxicology 44(4):616-622 (1990); & S.Hussain et al, � Mercuric chloride induced reactive oxygen species and its effect on antioxidant enzymes in different regions of rat brain � ,J Environ Sci Health B 1997 May;32(3):395 409;
Direct evidence for glutathione as mediator of apoptosis in neuronal cells
, Biomed Pharmacother, 1998; 52(9):349-55, A. Nicole et al,; & (b) J.S. Bains et al,
Neurodegenerative disorders in humans and role of glutathione in oxidative stress mediated neuronal death
, Brain Res Rev, 1997, 25(3):335-58; &
Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex
from patients with psychiatric disorders, J. W. Gawryluk, Jun-Feng Wang, A. C. Andreazza, Li Shao and L. T. Young, Int J Neuropsychopharm, June 2010
(158) Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity. � Shaw CA, Tomlienovic L; Immunol Res. 2013 Jul;56(2-3):304-16; & (b) 'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants. � Shoenfeld Y, Agmon-Levin N; J Autoimmun. 2011 Feb;36(1):4-8; &(c) � Sj � gren's syndrome: another facet of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Colafrancesco S, Perricone C, et al ; J Autoimmun. 2014 Jun;51:10-& (d) Aluminum in Childhood Vaccines Is Unsafe , Neil Z. Miller , Journal of American Physicians and Surgeons Volume 21 Number 4 Winter 2016; & (e) Infant mortality rates regressed against number of vaccine doses routinely given: is there a biochemical or synergistic toxicity? Miller NZ, Goldman GS; Hum Exp Toxicol. 2011 Sep;30(9):1420-8; & (f) Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum. Lyons-Weller J, Ricketson R. J Trace Elem Med Biol. 2018 Jul;48: 67-73
� (161) (a) � Concentrations of mercury in brain and kidney of fetuses and infants � , Journal of Trace Elements in Medicine and Biology, 1996,10:61-67, E. Lutz et al; & (b) G.Drasch et al, � Mercury Burden of Human Fetal and Infant Tissues � , Eur J Pediatr 153:607-610,1994;
(162) Toxic Levels of Mercury in Chinese Infants Eating Fish Congee", David Geier and Mark Geier, MD, PhD, Medical Journal of Australia, 2008
(163) Disconnected Kids: The Groundbreaking Brain Balance Program for Children with Autism, ADHD, Dyslexia, and Other Neurological Disorders ; Dr. Robert Melillo, 2009
(165) Rossignol Medical Center, Diagnosis Autism: A Simplified Biomedical Approach, https://rossignolmedicalcenter.com/wp-content/uploads/2017/10/Simplified-Biomedical-ASD-4.pdf ; & (b) Mitochondrial Dysfunction and Autism Spectrum Disorders, https://rossignolmedicalcenter.com/wp-content/uploads/2017/10/Mitochondrial-Dysfunction-ASD.pdf ; & (c) Cerebral Folate Deficiency in Autism, https://rossignolmedicalcenter.com/wp-content/uploads/2017/10/Cerebral-Folate-Deficiency-ASD.pdf
(170) (a) Mercury and autism: accelerating evidence? Mutter J, Naumann J, Schneider R, Walach H, Haley B. Neuro Endocrinol Lett. 2005 Oct;26(5):439-46; &(b) The relationship between mercury and autism: A comprehensive review and discussion. Kern JK, Geier DA, et al; J Trace Elem Med Biol. 2016 Sep;37: 8-24; & (c ) Background lead and mercury exposures: Psychological and behavioral problems in children. Gump BB, Dykas MJ, et al; Environ Res. 2017 Oct;158: 576-582.
(175) Silicon-Rich Mineral Water as a Non-Invasive Test of the Aluminum Hypothesis in � Alzheimer � s Disease ; https://www.researchgate.net/publication/230849470_Silicon-Rich_Mineral_Water_as_a_Non-Invasive_Test_of_the_%27Aluminum_Hypothesis%27_in_Alzheimer%27s_Disease
(184) (a) � Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal gland � , Arch Biochem Biophys, 1986, 248(2):467-78, J.C. Veltman et al,; &(b) Alfred V. Zamm. Dental Mercury: A Factor that Aggravates and Induces Xenobiotic Intolerance. J. Orthmol. Med. v6#2 pp67-77 (1991); & (d) Nishida M, Muraoka K, et al, Differential effects of methylmercuric chloride and mercuric chloride on the histochemistry of rat thyroid peroxidase and the thyroid peroxidase activity of isolated pig thyroid cells. J Histochem Cytochem. 1989 May;37(5):723-7;
(185) The relationship between mercury concentration in human organs and different predictor variables. Sci Total Environ 1993 Sep 30;138(1 3):101 15; Weiner JA, Nylander M.
(186) Life Extension Foundation, Disease Prevention and Treatment , Expanded 5 th Edition, 2013 & Life Extension Foundation, Life Extension, Jan 2009 (citing many studies). & http://www.life-enhancement.com/
(190) Metal-linked Immunosorbent Assay (MeLISA): the Enzyme-Free Alternative to ELISA for Biomarker Detection in Serum. Yu RJ, Ma W, et al; Theranostics. 2016 Jun 27;6(10):1732-9.
(196) A.F.Goldberg et al, � Effect of Amalgam restorations on whole body potassium and bone mineral content in older men � ,Gen Dent, 1996, 44(3): 246-8; & (b) K.Schirrmacher,1998, � Effects of lead, mercury, and methyl mercury on gap junctions and [Ca2+]I in bone cells � , Calcif Tissue Int 1998 Aug;63(2):134 9.
(198) B.R.G.Danielsson et al, � Ferotoxicity of inorganic mercury: distribution and effects of nutrient uptake by placenta and fetus � , Biol Res Preg Perinatal. 5(3):102-109,1984; & Danielsson et al, Neurotoxicol. Teratol., 18:129-134
(199) M. Nylander et al, Mercury accumulation in tissues from dental staff and controls � , Swedish Dental Journal, 13:235-243, 1989; & (b) Nylander M, � Mercury in pituitary glands of dentists � , Lancet,442, Feb 26, 1986.
(200) NeuroScience, Gottfried Kellermann, phD, http://ww1.prweb.com/prfiles/2010/07/16/3696064/MELISABrochure.pdf ; & Melisa, � http://www.melisa.org/mercury/
& (d) Take Charge of Your Health (Testing & Chelation of Heavy Metals) - Dr. Chris Shade - CEO of Quicksilver Scientific https://s115.podbean.com/pb/1860a0ddeed2ad45db31477355f265e8/60103875/data1/fs48/6936790/uploads/Take_Charge_1218208ati1.mp3?pbss=f02615a5-91d0-5c11-8e0e-81cca9f7c721
Metals as a common trigger of inflammation resulting in non-specific symptoms: diagnosis and treatment. Stejskal V.
Isr Med Assoc J. 2014 Dec;16(12):753-8; & Metal-specific lymphocyte reactivity is downregulated after dental metal replacement. Yaqob A 1 , Danersund A, Stejskal VD, Lindvall A, Hudecek R, Lindh U. Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):189-97; & LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Valentine-Thon E, Muller K, Guzzi, et al; Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:17-24.
(215) Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide. Kern JK, Geier DA, et al; Neuro Endocrinol Lett. 2014;35(7):537-52.
(263) Kumar AR, Kurup PA. Inhibition of membrane Na+-K+ ATPase activity: a common pathway in central nervous system disorders. J Assoc Physicians India. 2002 Mar;50: 400-6
(264) � Behavioral effects of prenatal metallic mercury inhalation exposure in rats � , Neurotoxicol Teratol, 1993, 15(6): 391-6, B.R. Danielsson et al,;& A. Fredriksson et al, � Prenatal exposure to metallic mercury vapor and methyl mercury produce interactive behavioral changes in adult rats � , Neurotoxicol Teratol, 1996, 18(2): 129-34
(273) Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS). H V Aposhian ; Environ Health Perspect. 1998 August; 106(Suppl 4): 1017 � 1025, www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1533322
(274) L.Friberg et al, � Mercury in the brain and CNS in relation to amalgam fillings � , Lakartidningen, 83(7):519-521,1986(Swedish Medical Journal), http://home.swipnet.se/misac/research6.html
(275) American Journal of Human Genetics, www.tinyurl.com/68s7j2 , Aug 2008
(333) A.J.Freitas et al, � Effects of Hg2+ and CH3Hg+ on Ca2+ fluxes in the rat brain � , Brain Research, 1996, 738(2): 257-64; & P.R.Yallapragoda et al, � Inhibition of calcium transport by Hg salts � in rat cerebellum and cerebral cortex � , J Appl toxicol, 1996, 164(4): 325-30; & E.Chavez et al, � Mitochondrial calcium release by Hg+2",J Biol Chem, 1988, 263:8, 3582-; A. Szucs et al, Cell Mol Neurobiol, 1997,17(3): 273-8; & D.Busselberg, 1995, � Calcium channels as target sites of heavy metals � ,Toxicol Lett, Dec; 82 83:255 61; & Cell Mol Neurobiol 1994 Dec;14(6):675 87; & Rossi AD, et al, Modifications of Ca2+ signaling by inorganic mercury in PC12 cells. FASEB J 1993, 7:1507-14.
(338) (a)W.Y.Boadi et al, Dept. Of Food Engineering and Biotechnology, T-I Inst of Tech., Haifa, Israel, � In vitro effect of mercury on enzyme activities and its accumulation in the first-trimester human placenta � , Environ Res, 1992, 57(1):96-106;& � In vitro exposure to mercury and cadmium alters term human placental membrane fluidity � , Pharmacol, 1992, 116(1): 17-23; & (b)J.Urbach et al, Dept. of Obstetrics & Gynecology, Rambam Medical Center, Haifa, Israel, � Effect of inorganic mercury on in vitro placental nutrient transfer and oxygen consumption � , Reprod Toxicol, 1992,6(1):69-75;& � Karp W, Gale TF et al, Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters � Environmental Research, 36:351-358; & W.B. Karp et al, � Correlation of human placental enzymatic activity with trace metal concentration in placenta � , Environ Res. 13:470- 477,1977; & (d) Boot JH. Effects of SH blocking compounds on the energy metabolism and glucose uptake in isolated rat hepatocytes. Cell Struct Funct 1995 Jun;20(3):233 8; & Semczuk M, Semczuk Sikora A. New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy. Med Sci Monit 2001 Mar;7(2):332 340
(369) Metals as a common trigger of inflammation resulting in non-specific symptoms: diagnosis and treatment. Stejskal V.
Isr Med Assoc J. 2014 Dec;16(12):753-8; & (b) � Sterzl I, Prochazkova J, Stejskal VDM et al, Mercury and nickel allergy: risk factors in fatigue and autoimmunity. Neuroendocrinology Letters 1999; 20:221-228; www.melisa.org
(382) The role of environmental factors in autoimmune thyroiditis. Hybenova M, Hrda P et al; Neuro Endocrinol Lett. 2010;31(3):283-9; & (b) Removal of dental amalgam decreases anti-TPO and anti-Tg autoantibodies in patients with autoimmune thyroiditis. Sterzl I, Stejsal V et al; Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:25-30; & Sterzl I, Fucikova T, Zamrazil V. The fatigue syndrome in autoimmune thyroiditis with polyglandular activation of autoimmunity. Vnitrni Lekarstvi 1998; 44: 456-60. www.melisa.org ; &(c) Sterzl I, Hrda P, Prochazkova J, Bartova J, Reactions to metals in patients with chronic fatigue and autoimmune endocrinopathy. Vnitr Lek 1999 Sep;45(9):527 31; &(d) The beneficial effect of amalgam replacement on health in patients with autoimmunity. Prochazkova J, Sterzl I, Kucerova H, Bartova J, Stejskal VD; Neuro Endocrinol Lett. 2004 Jun;25(3):211-8. www.melisa.org
(390) (a) Ellingsen DG, Efskind J, Haug E, Thomassen Y, Martinsen I, Gaarder PI - "Effects of low mercury vapour exposure on the thyroid function in chloralkali workers" J Appl Toxicol 20(6):483-9 (2000) , & (b) Barregard L, Lindstedt G, Schutz A, Sallsten G - "Endocrine function in mercury exposed chloralkali workers" Occup Environ Med 51(8):536-40 (1994) www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid= 7951778&form=6&db=m&Dopt=r ; & (e) Watanabe C, Yoshida K, Kasanuma Y, Kun Y, Satoh H. In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain.. Environ Res 1999 Apr;80(3):208-14.
(407) Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. J Neurol Sci. 2007 Nov 15;262(1-2):15-26. Epub 2007 Jul 24. . Rom � n GC.
(416) Kim P, Choi BH. � Selective inhibition of glutamate uptake by mercury in cultured mouse astrocytes � , Yonsei Med J 1995; 36(3): 299-305; & Brookes N. In vitro evidence for the role of glutatmate in the CNS toxicity of mercury. Toxicology 1992, 76(3):245-56; & Albrecht J, Matyja E. Glutamate: a potential mediator of inorganic mercury toxicity. Metab Brain Dis 1996; 11:175-84; & Tirosh O, Sen CK, Roy S, Packer L. Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death Neuroscience. 2000;97(3):531-41
(427) Chetty CS, McBride V, Sands S, Rajanna B. Effects in vitro on rat brain Mg(++)-ATPase. Arch Int Physiol
Biochem 1990, 98(5):261-7; & Bara M, Guiet-Bara A, Durlach J. Comparison of the effects of taurine and magnesium on electrical characteristics of artificial and natural membranes. V. Study on the human amnion of the antagonism between magnesium, taurine and polluting metals. [ French] Magnesium. 1985;4(5-6):325-32.
(496) Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 1999 Mar;81(3):163 221
(499) Environmental Quality Institute, Survey of mercury levels in hair in the U.S., www.greenpeace.org/usa/press-center/releases2/twenty-one-percent-of-women-te Accompanying data tables by State and Metropolitan Statistical Area www.greenpeace.org/usa/assets/binaries/addendum-to-mercury-report
(500)Annotated Bibliography: Adverse health effects related to mercury and amalgam fillings and clinically documented recoveries after amalgam replacement . Windham, B. (over 3000 peer-reviewed references); www.flcv.com/amalg6.html
(501) Review: Documentation of common mercury exposure levels from amalgam by medical labs, Government agency studies, peer-reviewed studies. B Windham (Ed), www.flcv.com/damspr1.html & www.flcv.com/amalno1.html
(502) Effects of prenatal and neonatal mercury exposure on children, B Windham (Ed), over 150 peer-reviewed studies, www.flcv.com/fetaln.html
(503) Summary of results of treatment of chronic health conditions by amalgam replacement, as reported to the FDA and treatment clinics, www.myflcv.com/hgrecovp.html
(508)(a) Bonar DB, McColgan B, Smith DR, Darke C, Guttridge MG, Williams HSmyth PPA, Hypothyroidism and aging: The Rosses � Survey. Thyroid 2000, 10(9):821-827;& (b) Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Tntern Med 2000, 160(4):526-34; &(c) GS Connection 11(12): Prevelence of Thyroid Imbalance, Thyroid in Pregnancy, GSDL, www.gsdl.com
(509)(a) Klein RZ, Sargent JD, Larsen PR, Waisbren Se, Haddow JE, Mitchell ML, Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen 2001: 8:18-20; &(b) de Escobar DM, Orbregon MF, del Rey FE, Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrin Metab 2000; 3975-3987; &(c) Thyroid Imbalances in Pregnancy Linked to Poor Child Neurodelopment, Great Smokies Diagnostic Lab, www.gsdl.com/news/connections/vol11/conn20010228.html
&(d) J. E. Haddow et al, Babies Born to Mothers with Untreated Hypothyroidism Have Lower I.Q.'s, New England Journal of Medicine, Aug 19, 1999; & (e) Lavado-Autric et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. JCI 111:1073-1082 (2003); & (f)Pop VJ, Vader HL et al, Low maternal free thyroxine during early pregnancy is associated with impaired psychomotor development in infancy, Clin Endocrinol(Oxf), 50:149-55, 1999; & Man EB, Brown JF, Serunian SA. Maternal hypothyroxinemia: psychoneurological deficits of progeny. Ann Clin Lab Sci 1991;21(4):227-39; & Pharoah POD, Connolly KJ et al, Maternal thyroid hormone levels in pregnancy and cognitive and motor performance of the children, Clin Endocrinol(Oxf), 1984, 21:265-70; & (g) Pop VJ, de Vries E, et al, Maternal thyroid peroxidase antibodies during pregnancy: and impaired child development, J Clin Endocrinol Metab., 1995, 80:3561-3566 & Connors MH, Styne DM, Neonatal athyreosis resulting from thyrotropin-binding inhibitory immonoglobulins, Pediatrics, 1986, 78:287-290; & (h) Asami T, Suzuki H, Effects of thyroid hormone deficiency on electrocardiogram findings of congenenitally hypothyroid neonates. Thyroid 11: 765-8, 2001; & Kumar R, Chaudhuri BN. Altered maternal thyroid function: fetal and neonatal heart cholesterol and phospholipids, .Indian J Physiol Pharmacol 1993 Jul;37(3):176-82
(510) (a)Morris MS, Bostom AG, Jacques PJ, Selhub J, Rosenberg IH, Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third U.S. National Health and Nutrition Examination Survey, Artherosclerosis 2001, 155:195-200; & (b) Shanoudy H. Soliman A, Moe S, Hadian D, Veldhuis F, Iranmanesh A, Russell D, Early manifestations of � sick eythyroid syndrome � in patients with compensated chronic heart failure, J Card Fail 2001, 7(2):146-52; & (c)AE. Hak, HAP. Pols, TJ. Visser, et al., The Rotterdam Study., Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women, Ann Int Med, 2000, vol. 132, pp. 270--278 &(d)Thyroid Dysfunction Linked to Elevated Cardiac Risk, GSDL, www.gsdl.com/news/connections/vol12/conn20010411.html.; &(e) Biondi B, Palmieri EA, Lombardi G, Fazio S. Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med 2002 Dec 3;137(11):904-14; & (f) B.G. Nedreboe, O. Nygard, et al, Plasma Total Homocysteine of hypothyroid patients during 12 months of treatment, Haukeland Univ. Hospital, Bergen, Norway, email@example.com (references 7 other studies with similar findings); & (g) Hussein, WI, Green, R, Jacobsen, DW, Faiman, C. Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism. Ann Intern Med 1999; 131:348;
(511) (a) Abramson J, Stagnaro-Green A, Thyroid antibodies and fetal loss, Thyroid 2001, 11(1): 57-63; &(b) Thyroid Antibodies May Spur Pregnancy Loss, GSDL, www.gsdl.con/news/connections/vol12/conn20010411.html
& (c)Allan W.(MD), Maternal Hypothyroidism During Pregnancy Linked to Increased Risk for Miscarriage, Journal of Medical Screening, November 22, 2000; & (d) Abstract # 274: Wolfberg, Adam J. and David A. Nagey, "Thyroid Disease During Pregnancy and Subsequent Congenital Anomalies."St Johns Univ., firstname.lastname@example.org ; & Birth Defect News, Jan 2002, p2; & (e)Emerson, C.H. (1996). Thyroid Disease During and After Pregnancy. In L.E. Braverman & R.D. Utiger (Eds.), The Thyroid, A Fundamental and Clinical Text (pp. 1021-1031; & (f) Man EB, Jones WS, Thyroid function in human pregnancy: retardation in 8-month old infants, Am J Obstet Gynecol, 1969, 104:898-908; & Brent GA, Maternal hyrothyroidism: recognition and management, Thyroid, 1999, 9:661-5.
(521) Guermonprez L, Ducrocq C, Gaudry-Talarmain YM. Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants. Mol Pharmacol 2001 Oct;60(4):838-46; & Mahboob M, Shireen KF, Atkinson A, Khan AT. Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J Environ Sci Health B. 2001 Sep;36(5):687-97.
(522) Nutrition Supplements Found Effective for Metal Disorders, Dr. Julia Rucklidge, University of Canterbury, Journal of Attention Disorders , January 2010 (EMPowerPlus, TrueHope) www.truehope.com/truehope_bipolar_disorder_research_empowerplus_1.aspx & Pfeiffer Treatment Clinic, www.hriptc.org/content/behavioralDisorders.php
(524) Torreilles F, Salman-Tabcheh S, Guerin M, Torreilles J. Neurodegenerative disorders: the role of peroxynitrite.Brain Res Brain Res Rev 1999 Aug;30(2):153-63; & (b)Aoyama K, Matsubara K, Kobayashi S. Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases. Ann Neurol 2000 Apr;47(4):524-7; &(c ) Guermonprez L, Ducrocq C, Gaudry-Talarmain YM. Inhibition of acetylcholine synthesis and tyrosine nitration induced by peroxynitrite are differentially prevented by antioxidants. Mol Pharmacol 2001 Oct;60(4):838-46
(555) Lewis RN; Bowler K. Rat brain (Na+ K+)ATPase: modulation of its ouabain sensitive K+ PNPPase activity by thimerosal. Int J Biochem 1983;15(1):5 7; Bellabarba D, and Tremblay R; Effect of thimerosal on serum binding of thyroid hormones, Can J Physsiol Pharmacol,173, 51:156-159: & Hokkfen B, Kodding R, Hesch RD; Regulation of thyroid hormone metabolism in rat liver fractions, Biochim Biophys Acta 1978, 539:(1): 114-24.
(558) American Assoc. of Clinical Endocrinologists and American College of Endocrinolog. AACE clinical practice guidelines for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract., 1995, 1: 54-62.
(559) A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization Against Human Papilloma Virus, Journal of Child Neurology, Vol. 25, No. 3, 321-327 (2010), FJ DiMario, M Hajjar, & JAMA, Aug 18, 2009, &
tag=cbsnewsTwoColUpperPromoArea & http://articles.mercola.com/sites/articles/archive/2009/08/08/Hundreds-of-Thousands-of-Reactions-to-Gardasil-Is-Your-Child-Next.aspx
(560) Susanna Visser et al, U.S. Center for Disease Control (CDC), and NBC Nightly News, 11-10-2010,
(561) J Stevenson et al, Common Food Additives found to cause and increase ADHD behavior problems in some children, The Lancet, Sept 6, 2007; & A Kemp , BMJ, 2008; & Food Additives, What you eat can kill you, The Blaylock Report, Dr. Russell Blaylock, Vol 4, No. 10, http://www.blaylockreport.com/
(562) (a) ADHD and Toxic manganese Exposure, Dr Frank Crinella, www.vrfca.org/manganese/chemical-imbalances/adhd ; & Prenatal Manganese Levels Linked to Childhood Behavioral Disinhibition, Jonathon E. Ericson et al, & Baby teeth measure link between toxic metals and ADHD, www.vrfca.org/files/vrf/Today@UCI%20Baby%20teeth%20Karen%20Morris%20Pg%201.pdf ;& (b) Reduced violent behavior following biochemical therapy (for toxic metals and chemical imbalances), William J. Walsh et al, Physiology & Behavior 82 (2004) 835 � 839; & (c) Autism, ADHD, and other developmental conditions- the vaccine/toxic metal connection, review: www.flcv.com/tmlbn.html
(563) Heavy Metal and Chemical Toxicity, Dietrich Klinghardt, MD, Ph.D. www.neuraltherapy.com/chemtox.htm ; & Mercury Toxicity and Systemic Elimination Agents, D. Klinghardt & J Mercola(DO), J of Nutritional and Environmental Medicine, 2001, 11:53-62;
(570) Vaccine Induced Autism & ADHD (Mercury), David Ayoub, M.D. http://whale.to/vaccines/ayoub_h.html & http://whale.to/vaccine/ayoub_v.html ;
& https://vaccinetruth.org/dr-david-ayoub.html ; & (b) Federal Court Compensated 83 Vaccine-Injured Autistic Children, http://ahrp.org/federal-court-compensated-83-vaccine-injured-autistic-children/
Dr. Andrew Moulden, http://vaccine-injury.info/moulden.cfm ; & http://vaccine-injury.info/moulden.cfm#_
(571) Vaccine Induced Autism & ADHD (Aluminum), David Ayoub, M.D. https://articles.mercola.com/sites/articles/archive/2010/03/20/david-ayoub-interview-february-2010.aspx ; & Systemic Toxicity of Aluminum Adjuvants, � Dr Suzanne Humphries, MD, http://vaccine-injury.info/aluminum.cfm
(572) � Dr. Garth Nicholson, How Vaccines Cause Mitochondrial Damage, http://vaccine-injury.info/garth-nicolson.cfm ; & As Enterovirus D68 Deaths Increase, Are Vaccine Contaminants to Blame?; http://vaccineimpact.com/2014/as-enterovirus-d68-deaths-increase-are-vaccine-contaminants-to-blame/
Mycoplasma the Linking Pathogen in Neurosystemic Diseases; Donald W. Scott, MA, MSc Special to Salem-News.com; Mar-03-2013 16:30
(573) Kawasaki's disease, acrodynia, and mercury. Mutter J , Yeter D . Curr Med Chem. 2008;15(28):3000-10.
(574) ABC News April 14, 2010,
(575) M Olczak , M Duszczyk , P Mierzejewski and M D Majewska . Brain Research, Volume 1301, November 16 , 2009 , pp. 143-151
(576) A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels: a further assessment of the Casa Pia Children's Dental Amalgam Trial ; DA Geier, T Carmody, JK Kern, PG King, and MR Geier; Hum Exp Toxicol , 29 July 2011
(580) Life Extension Foundation (MDs), Disease Prevention and Treatment , Expanded 4 th Edition, 2003 , http://www.life-enhancement.com/
(581) The Center for Modeling Optimal Outcomes LLC, Mechanism commonly causing autism found, www.news-medical.net/news/20091118/The-Center-for-Modeling-Optimal-Outcomes-discovers-causal-path-of-autism.aspx , www.thecenternj.com/lifesciences.html_/ ; & (b) Willis Langford, A Comprehensive Guide to Mastering Autism, Autoimmunity, and Other Neurological Disorders 2007& Dr. J. Wright.
(582) Aluminum Hydroxide: Another Poison Pediatricians Inject in Babies; IMVA, http://imva.info/index.php/vaccines/aluminum-hydroxide/ ; & (b) � Vaccines Show Sinister Side � March 23,2006, www.straight.com/content.cfm?id=16717 ; (c) Blaylock, Russell. The Blaylock Wellness Report Vol 1, Issue 1; & (d) Cave, Stephanie, Mitchell, Deborah � What Your Doctor May Not Tell You About Children � s Vaccinations � , Warner Books, 01 September, 2001; & (e) Waly, M. et al Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Department of Pharmaceutical Sciences, Northeastern University. Molecular Psychiatry (2004) 1-13; & (f) Haley, Boyd. Mercury and Thimerosal Toxicity: A Factor in Autism; & (g) Dr. Fudenberg � s comments above were from his speech at the NVIC International Vaccine Conference, Arlington VA September, 1997; & (h) http://www.chinadaily.com.cn/china/2006-03/25/content_552145.htm
(583) Wireless Radiation in the Etiology and Treatment of Autism: Clinical Observations
and Mechanisms; J. Aust. Coll. Nutr. & Env. Med. Vol. 26 No.2 (August 2007) pages 3-7; Tamara J Mariea , George L Carlo
(584) Authier FJ, Cherin P, et al. Central nervous system disease in patients with macrophagic myofasciitis. Brain 2001; 124: 974-983.
(585) Dr. Woody McGinnis, paper: Autism Conference, Calgary, 2006.
(593) Immunoexcitotoxicity and Autism, R L Blaylock, Alt Ther Health Med, 2008, 14:46-53.
(595) Psychology Today April 23, 2011 ; & Is autism an autoimmune disease?, P. Ashwood, J. Van de Water / Autoimmunity Reviews 3 (2004) 557 � 562 (b) International Review of Psychiatry, December 2005; 17(6): 485 � 495 (PDF) ; & � Immunity, neuroglia and neuroinflammation in autism, CARLOS A. PARDO, DIANA L. VARGAS, & ANDREW W. ZIMMERMAN, International Review of Psychiatry, December 2005; 17(6): 485 � 495 , http://healing-arts.org/children/mercury_in_vaccines_autism_research/Immunity_Neuroinflammation_Autism_Study.pdf
(596) Effects of antidiabetic and antihyperlipidemic agents on C-reactive protein.
Mayo Clin Proc. 2008 Mar;83(3):333-42, Dandona P; & (b) Misfolded neural proteins linked to some Autism Disorders, P Taylor et al, Journal of Biological Chemistry, Sept 10, 2010
(597) Effects of mercuric chloride on glucose transport in 3T3-L1 adipocytes. Toxicol In Vitro. 2005 Mar;19(2):207-14. Barnes DM, Kircher EA; & Effects of inorganic HgCl2 on adipogenesis. Toxicol Sci. 2003 Oct;75(2):368-77. Epub 2003 Jul 25, Barnes DM, Hanlon PR, Kircher EA; & (b) Heavy metal-induced inhibition of active transport in the rat small intestine in vitro. Interaction with other ions. Comp Biochem Physiol C. 1986;84(2):363-8, Iturri SJ, Pe � a A; & Interaction of the sugar carrier of intestinal brush-border membranes with HgCl2. Biochim Biophys Acta. 1980 May 8;598(1):100-14, Klip A, Grinstein S, Biber J, Semenza G.
(598) (a) The Blaylock Wellness Report, Russell Blaylock (Neurologist), The Danger of Vaccinations, Vol 5, No. 3, March 2008; & (b) The Blaylock Wellness Report, Vol 4, No. 10, Oct 2007; www.blaylockreport.com/ ; & (c) What They Don � t Tell You About Vaccination Dangers Can Kill You or Ruin Your Life By Russell L. Blaylock, M.D. http://www.whale.to/a/blaylock34.html ; & (d) Russell Blaylock, "The Danger of Excessive Vaccination During Brain Development: The Case for a Link to Autism Spectrum Disorders:" 2008, http://articles.mercola.com/sites/articles/archive/2008/03/14/the-danger-of-excessive-vaccination-during-brain-development.aspx
(599) High fructose consumption combined with low dietary magnes"The Danger of Excessive Vaccination During Brain Development: The Case for a Link to Autism Spectrum Disorders:" ium intake may increase the incidence of the metabolic syndrome by inducing inflammation. Magnes Res. 2006 Dec;19(4):237-43. Rayssiguier Y, Gueux E, et al; & (b) Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr. 2006 Nov;84(5):1062-9 Bo S, Durazzo M, Pagano G. et al; & (c) Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):471-6. Guerrero-Romero F, Rodr � guez-Mor � n
(600) Low Budget ABA (Applied Behavior Analysis) Treatment, Detailed information on the course is available on Maximum Potential's site: http://www.maximumpotentialkids.com
(603) Diagnosis and Treatment of Heavy Metal Toxicity in Autism Spectrum Disorders(ASD), DAN Medical Subcommittee on Autism and Mercury, J Bradstreet, J El-Dahr, A Holmes, S Cave, and B Haley, 2000.