Mercury and food intolerances: common causes
of chronic conditions related to leaky gut and intestinal dysfunction such as
ulcerative colitis, IBS, Crohn’s, eczema, psoriasis, food allergies, arthritis,
ADHD, and autoimmune disease; and treatments that improve these conditions.
When intestinal permeability is increased, food
and nutrient absorption is impaired. Dysfunction in intestinal permeability can
result in leaky gut syndrome, where larger molecules and toxins in the
intestines can pass through the membranes and into the blood, triggering immune
response (6,303). Progressive damage can occur to the
intestinal lining, eventually allowing disease-causing bacteria, undigested
food particles, and toxins to pass directly into the blood
stream. Dysfunctions in intestinal permeability have been found to
be associated with diseases such as leaky gut syndrome (LGS), ulcerative
colitis, irritable bowel syndrome (IBS), Crohn’s disease, CFS, eczema,
psoriasis, food allergies, autoimmune disease, and arthritis (1abcdefgh,2b,6,302,303,406).
Symptoms commonly associated with LGS include: abdominal pain, indigestion,
diarrhea, anxiousness, chronic joint pain, chronic muscle pain, mental
confusion, mood swings, poor memory, poor immunity and recurrent infections,
bloating, fatigue. (487).
Although there are also other causes of LGS,
mercury and toxic metals have been found to be common toxic exposures that can
cause increased intestinal permeability and intestinal dysfunction
(2,338,303,406), as well as of the kidney epithelial and brush border cells. Mercury
exposure also reduced the mucosal entry of sugars and amino acids to 80-90% of
control levels in the small intestine cells within several minutes(3a). Mercury
exposure blocks intestinal nutrient transport by interacting directly with
brush border membrane transport proteins (3b). Mercury also
causes increase of inflammatory cytokines such as TNFa,
IL-6, and IL-1b (480). Amalgam dental
fillings are the largest cause of mercury in most people, and results in
exposure to mercury vapor, inorganic mercury and methylmercury, since oral
bacteria methylate inorganic mercury. EMF and Wi-fi increase
mercury vapor exposure and thus chronic damage.
Mercury
causes significant destruction of stomach and intestine epithelial cells,
resulting in damage to stomach lining which along with
mercury’s ability
to bind to SH hydroxyl radical in cell membranes alters permeability
(338,405,35,21c,2) and adversely alters bacterial
populations in
the intestines causing leaky gut syndrome with toxic, incompletely digested
complexes in the blood (116,228b,35,6) and
accumulation of
heliobacter pylori, a suspected major factor in stomach ulcers
and stomach cancer (256,6bc) and Candida albicans,
as well
as poor nutrient absorption (338,3).
Dental amalgam has been
found by thousands of medical lab tests and by medical studies to be the largest source of mercury exposure
in most people who have several amalgam fillings (7). EMF
or Wi-fi exposure increase mercury vapor exposure from amalgam
fillings, increasing the toxic damage. Susceptibility
factors that reduce the body’s detoxification processes ability to
detoxify toxic metals are a major factor in who is affected by mercury or toxic
metal exposure and to what extent. Replacement of amalgam fillings and metals
detoxification have been found to significantly improve the health of most
with conditions related to bowel dysfunction and leaky gut syndrome) 8,9,302,303).
Other
common causes or factors in leaky gut and the related conditions include
food allergies and intolerances; drugs (NSAIDs,
aspirin,
stomach h2 blockers, steroids, etc.); Dysbiosis (overgrowth of harmful organisms
due to antibiotic use and/or low probiotic levels);
chronic alcohol
consumption; synergistic toxic
exposures and chemical sensitivity; chronic infections;
inadequate digestive enzymes (6b)
While
food allergies mediated by IgE can cause significant
health effects including leaky gut syndrome, these are usually
easily
identified by
the immediateness of reactions or skin tests. Food intolerances mediated
by IgG also commonly cause significant health
effects including
leaky gut syndrome, but the reactions are delayed and can be systemic
and are harder to identify. Tests based on IgE
such as
skin test or RAST do not reliably identify such problems that are common
factors in chronic health conditions and tests such as
ELISA
that measure both IgE and IgG are more reliable.
Common causes of food intolerances include failure to breast feed
babies for at
least the
first year of life, feeding table food in first year of life, use of antibiotics without
adequate addition of probiotics; eating the same foods every day(6b).
Food intolerances and food additives or processed foods that contain
glutamate, aspartame, high-fructose corn syrup, dyes, etc. are common
causes of leaky gut syndrome and neurological conditions such as
ADHD(6b).
Food
intolerances and IgG reactions lead to long lasting “immune complexes”
that are factors in leaky gut related conditions as well as
conditions such
as Lupus, rheumatoid arthritis, CFS, fibromyalgia, ADHD,
etc. Inflammatory reactions to toxic metals, vaccines, food
additives,
food intolerances not only cause immune reactions but also reactions in
the neurological microglial system. This can cause brain
fog,
memory problems, and degenerative neurological conditions if prolonged chronic
exposures (6). For example, virtually 100% of those
with schizophrenic
symptoms in schizophrenia, autism, ADHD, are found when tested to
have food intolerance to wheat gluten or milk
casein(6bd). Enzymatic
blockages by chronic toxic metal exposures such as vaccines or
mercury have been found to be a factor in these
food intolerances. Similarly,
this is the most common cause or factor in celiac disease and common
cause of ataxia and diabetes(6bde).
Similarly,
food allergies or additives, food intolerances, high sugar consumption,
and antibiotic use with adequate probiotics have been
found to
be the most common causes of children’s ear infections. Clinical studies
have found that diets high in flavanoids, cartenoids,
and including
nutritional supplements such as buffered Vit C
and natural E, selenium, omega-3 oils, probiotics are effective in
preventing ear
infections and other chronic conditions(6b). These in addition to
multiple B vitamins, the flavanoids curcumin,
hesperidin,
and quercetin
are effective in preventing and treating leaky gut related conditions (6,480).
Crohn’s
disease usually occurs at a relatively young age and results when an
immune or autoimmune response causes increased
inflammatory cytokines
like TNFa, IL-6, and IL-1b, resulting ininflammation of the ileum or colon(480).
This usually results in
thinning of
the bowel wall and often formation of ulcers on the intestinal
lining. Functional neutrophil deficiencies are often a
factor in
Crohn’s disease. In addition to improvements in many patients after
amalgam replacement and detoxification, diet and
nutritional measures
are usually effective at improving Crohn’s Disease(580). The
4-R program has seen good success in many
patients. The
program removes all foods where there is suspicion of allergy that
might produce inflammation. Common allergens include
wheat/gluten,
dairy, eggs, peanuts, tomatoes, corn, and red meat. Additionally,
elimination of gastrointestinal parasites, undesirable
bacteria,
fungus, and yeasts are carried out. Sometimes a treatment such as nystantin is used to eliminate yeast (480). Then vital
nutrients
are replaced
by dietary measures and supplementation of a good multivitamin and
mineral, minerals found deficient such as iron,
magnesium,
calcium, selenium, zinc, iodine and vitamins such as B-complex, B6, B12, folic
acid. Next the intestines are reinocculated
with
friendly bacteria(Lactobacillus acidophilus and Lactobacilus
bulgaricus. Finally, measures are taken to repair the intestine to correct
for thee
increased permeability.
This is done by adding nutrients such as glutamine, pantothenic acid (B5),
zinc, FOS, and vitamin C.
DHEA and
Butyrate have also been found effective in many patients at reducing inflammation
(480).
Supplements and other treatments
that reduce intestinal permeability have also been found to be
protective against and to
improve these
conditions. Glutamine, berberine, probiotics, and vitamin D have been
found to decrease intestinal permeability and
protect against
effects caused by leaky gut syndrome (4,5,480,487). Butyrate has been
found to inhibit inflammation and carcinogenesis in the intestines
and low butyrate levels are found in colon cancer, ulcerative colitis,
and Crohn’s disease (10). Butyrate and
phosphatidylcholine have
been found to be protective against these conditions, and increased fiber
content in diet promotes increased
butyrate levels,
through the effect on fermentation pattern (10).
Supplementation with chlorella has been found to result in beneficial
effects when used in patients chronic conditions such
as ulcerative colitis, hypertention,
or Fibromyalgia (304). Doctors such as D. Klinghardt
(303) have suggested that the mechanism by which chlorella improves treatment
of such conditions is metals detoxification, which is the main mechanism of
action of chlorella and has been found to greatly improve intestinal function.
Brain
inflammation or hypoglycemia related to toxic metal
exposures,
food intolerances, etc. have been found to be common
causes of
ADHD, impulsivity, juvenile delinquency, criminality, and
violence (6b,11,115).
Detoxification, diet measures, and
supplementation for
deficient vitamins and minerals have been found
to usually
improve such conditions.
References:
1(a) Altered
permeability in inflammatory bowel disease: pathophysiology and clinical
implications. Curr Opin
Gastroenterol. 2007 Jul;23(4):379-83Mankertz J, Schulzke
JD; & (b) Increased intestinal permeability in patients with inflammatory
bowel disease. Eur J Med Res. 2004 Oct
29;9(10):456-60; Welcker K, Martin A, Kölle P, Siebeck M, Gross M;
& (c ) The significance of bowel
permeability. Curr Opin
Clin Nutr Metab Care. 2007 Sep;10(5):632-8; Soeters PB, Luyer MD, Greve JW, Buurman WA; & (d)
New diseases derived or associated with the tight junction. Arch Med Res.
2007 Jul;38(5):465-78; Cereijido M, Contreras
RG, Flores-Benítez D, Flores-Maldonado C, Larre I,
Ruiz A, Shoshani L; & (e)Gastrointestinal
symptoms and permeability in patients with juvenile idiopathic arthritis. Clin Exp Rheumatol.
2003 Sep-Oct;21(5):657-62; Weber P, Brune
T, Ganser G, Zimmer KP; & (f)Intestinal
permeability in patients with adverse reactions to food, Dig. Liver Dis , 2006, Oct, 38(10):732-6; & (g) Altered intestinal
function in patients with chronic heart failure, J Am Coll Cardiol,
2007, Oct 16; 50(16):1561-9; & (h) Mechanisms of disease: the
role of intestinal barrier function in the pathogenesis of gastrointestinal
autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol. 2005
Sep;2(9):416-22. Fasano A, Shea-Donohue
T.
(2)(a) Direct and
indirect actions of HgCl2 and methyl mercury chloride on permeability and
chloride secretion across the rat colonic mucosa. Toxicol
Appl Pharmacol. 1992
Jun;114(2):285-94; Böhme M, Diener M, Mestres P, Rummel W. & (b) Enhancement of ovalbumin-induced
antibody production and mucosal mast cell response by mercury. Food Chem Toxicol. 1999
Jun;37(6):627-37; Watzl B, Abrahamse SL, Treptow-van Lishaut S, Neudecker
C, Pool-Zobel BL. & (c)
Multiple effects of mercury on cell volume regulation, plasma membrane
permeability, and thiol content in the human intestinal cell line
Caco-2. Cell Biol Toxicol.
2005 May-Jul;21(3-4):163-79 Aduayom I, Denizeau F, Jumarie C. & (d) Effects of dimethylsulfoxide
and mercurial sulfhydryl reagents on water and solute permeability of rat
kidney brush border membranes. Biochim
Biophys Acta. 1990 Dec
14;1030(2):203-10; van Hoek AN, de Jong MD, van Os CH.
(3)Mercurial
perturbation of brush border membrane permeability in rabbit
ileum. J Membr Biol. 1975 Aug
11;23(1):33-56. Stirling CE.; & (b) HgCl2 inhibition of nutrient
transport in teleost fish small intestine. J Pharmacol
Exp Ther. 1981 Jan;216(1):70-6. Miller
DS.
(4) Intestinal permeability and systemic
infections in critically ill patients, effect of glutamine, Crit
Care Med. 2005 May, 33(5):1175-8; & (b)Protective effect of
glutamine on intestinal barrier function in patients receiving chemotherapy, Zhonghua Wei Chang Wai Ke Za Zhi 2006, Jan, 9(1):59-61,
Jiang H P, Liu CA; & (c) Berberine inhibits ion transport in human colonic
epithelia, Eur J Pharmocol,
1999, Feb 26; 368(1):111-8.
(5) Probiotics prevent
bacterial translocation and improve intestinal barrier function in rats
following chronic stress, Gut 2006, Nov,
55(11):1553-60, Zareie M, Jury J, Yang PC; Sherman
PM; & (b) Probiotics and inflammatory bowel
diseases. Postgrad Med J. 2006 Jun;82(968):376-82. Bai AP, Ouyang Q;
& (c) Novel role of the vitamin D receptor in maintaining the integrity of
the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16. Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart
J, Bissonnette M, Li YC.
(6) (a) Hidden Causes of GI Dysfunction, C.D.
Meletis, Vitamin Research News, vol 22,
no.4,
April 2008; & (b)
Are You the Victim of Hidden Allergies?, The Blaylock
Wellness
Report, Vol 4, No. 11,
Nov 2007; & (c) Food Additives: What You Eat Can Kill You, The Blaylock
Wellness Report, Vo. 4, No. 10, Oct 2007 www.blaylockreport.com
& (d) http://www.myflcv.com/autismgc.html; &(e) http://www.myflcv.com/diabetes.html; & (f) http://www.myflcv.com/kidshg.html
(7) Mercury exposure levels from dental
amalgam, medical lab tests and medical studies, B. Windham (Ed), 2007, http://www.myflcv.com/damspr1.html
(8) Documentation of recovery of significant
improvement in over 30 chronic health conditions after amalgam replacement, peer-reviewed studies and clinical
studies, http://www.myflcv.com/hgremove.html
(9) Percentage with significant health
improvement after dental amalgam replacement by chronic condition, FDA reports
and clinical case reports, www.flcv.com/hgrecovp.html
10(a) The
role of butyrate on colonic function, Aliment Pharmocol
Ther, 2008 Jan 15:27(2):104-119, Hamer HM, Jonkers, d et al; & (b) Dietary modulation of colon
cancer risk, J Nutr 2007, Nov 137(11 Suppl):2576S-2579S, Kim YS, Milner JA; & (c) Mucosal
metabolism in ulcerative colitis and Crohn’s Disease, Dis Colon Rectum, 1998,
Nov: 41(11):1399-1405; & (d) Down-regulation of the onocarboxylate
transporter 1 is involved in butyrate deficiency during intestinal
inflammation, Gastroenterology, 2007, Dec 133(6):1916-27; & (e)
Influence of dietary fiber on inflammatory bowel disease and colon cancer:
importance of fermentation pattern, Nutr Rv. 2007
Feb,65(2):51-62; & (f) Effect of polyunsaturated fatty acid-enriched
phosphatidylcholine and phosphatidylserine on butyrate-induced growth
inhibition, differentiation, and apoptosis in Caco-2 cells, Cell Bichem Funct 2006 Mar-Apr,
24(2):159-65; & (g)Oral butyrate for mildly to moderately active Crohn's
disease,
& Di Sabatino A, Morera R, Corazza GR. Et al, Aliment
Pharmacol Ther. 2005
Nov 1;22(9):789-94
(11) Toxic metal exposures common factors in
ADHD, violence, impulsivity, juvenile delinquency, and criminality; B.Windham (Ed), http://www.myflcv.com/violence.html
(20) Denton,
Sandra, M.D., The Mercury Cover-Up: Controversies in Dentistry, Townsend Letter
For Doctors, July 1990;488-491
(21) R.A.Goyer,”Toxic
effects of metals”in: Caserett
and Doull’s Toxicology- TheBasic Science of Poisons, McGraw-Hill Inc., N.Y., 1993;
&(b) Goodman, Gillman, The Pharmacological Basis of Therapeutics, Mac
Millan Publishing Company, N.Y. 1985; &(c) Encyclopedia of Occumpational Health and Safety, International Labour Office, Geneva, Vol 2, 3rd Edition.
(33)
(a) Markovich et al, "Heavy metals
(Hg,Cd) inhibit the activity of the liver and kidney
sulfate transporter Sat‑1", Toxicol Appl Pharmacol, 1999,154(2):181‑7;
& (b)2S.A.McFadden, “Xenobiotic metabolism and adverse environmental
response: sulfur-dependent detox pathways”,Toxicology,
1996, 111(1-3):43-65; &(c) Alberti A, Pirrone
P, Elia M, Waring RH, Romano C. Sulphation
deficit in “low-functioning” autistic children. Biol
Psychiatry 1999, 46(3):420-4.
(35) (a)Levy
T.E., Huggins HA, Uniformed Consent: the hidden dangers in dental
care, 1999, Hampton Roads Publishing Company Inc;
(40) Anti-metallothionein IgG
and levels of metallothionein in autistic families. Russo AF, Swiss Med Wkly. 2008 Feb 9;138(5-6):70-7.
(43) (a)Knapp LT; Klann
E. Superoxide‑induced stimulation of protein kinase C via thiol modification and modulation of zinc
content. J Biol Chem 2000
May 22; &(b) B.Rajanna et al, “Modulation of
protein kinase C by heavy metals”, Toxicol Lett,
1995, 81(2-3):197-203: & A.Badou et al,
“HgCl2-induced IL-4 gene expression in T cells involves a protein kinase
C-dependent calcium influx through L-type calcium channels”J
Biol Chem. 1997 Dec 19;272(51):32411-8., & D.B.Veprintsev, 1996, Institute for Biological
Instrumentation, Russian Academy of Sciences, Pb2+ and Hg2+ binding
to alpha‑lactalbumin”.Biochem Mol
Biol Int 1996
Aug;39(6):1255‑65
(51) Heintze et
al,“Methylation of Mercury from
dental amalgam and mercuric chloride by
oral Streptococci”.,Scan. J. Dent. Res. 1983, 91:150‑152: &
Wang J, Liu Z; [.In vitro Study of Strepcoccus
Mutans in the Plaque on the Surface of Amalgam
Fillings on the Conversion of Inorganic Mercury to Organic Mercury][Article in
Chinese], Shanghai Kou Qiang Yi Xue.
2000 Jun;9(2):70-2; & L.I.Liang
et al, "Mercury reactions in the human mouth with dental amalgams"
Water, Air, and Soil pollution, 80:103-107; & (b) Rowland,
Grasso, Davies “The Methylation of Mercuric Chloride by
Human Intestinal Bacteria”. Experientia. Basel
1975 ,31: 1064‑1065; & M.K.Hamdy
et al, “Formation of methyl mercury by bacteria”, App Microbiol,
1975, Sept.; & Ludwicki JK Studies on the role of
gastrointestinal tract contents in the methylation of inorganic mercury
compounds Bull Env Contam Toxicol 42 1989 283-288;
& (c) Choi SC, Bartha R.. Cobalamin-mediated mercury
methylation by Desulfovibrio desulfuricans
LS. Appl Environ Microbiol.
1993 Jan;59(1):290-5;
(54) M.E. Lund et al,
“Treatment of acute MeHg poisoning by NAC”, J Toxicol Clin Toxicol,
1984, 22(1):31-49; & Livardjani
F; Ledig M; Kopp P; Dahlet
M; Leroy M; Jaeger A. Lung and blood superoxide dismustase
activity in mercury vapor exposed rats: effect of N‑acetylcysteine
treatment. Toxicology 1991 Mar 11;66(3):289‑95
(96) Goyer RA, National
Institute of Environmental Health Sciences. Toxic and essential
metal interactions. Annu Rev Nutr 1997; 17:37-50; & Nutrition and metal
toxicity. Am J Clin Nutr
1995; 61(Suppl 3):
646S- 650S; & Goyer
RA et al, Environmental Risk Factors for Osteoporosis, Envir
Health Perspectives, 1994, 102(4): 390-394; ; &
Lindh U, Carlmark B, Gronquist
SO, Lindvall A. Metal exposure from amalgam alters
the distribution of trace elements in blood cells and
plasma. Clin Chem
Lab Med 2001 Feb;39(2):134‑142. ; & A.F.Goldberg
et al, “Effect of Amalgam restorations on whole body potassium and bone mineral
content in older men”,Gen Dent, 1996,
44(3): 246-8; & K.Schirrmacher,1998, “Effects of lead, mercury, and methyl
mercury on gap junctions and [Ca2+]I in bone cells”, Calcif
Tissue Int 1998 Aug;63(2):134‑9.
(111) (a) Quig D, Doctors Data Lab,"Cysteine metabolism and metal toxicity", Altern Med Rev, 1998;3:4, p262‑270,
& (b) J.de Ceaurriz et al,
Role of gamma‑ glutamyltraspeptidase(GGC)
and extracellular glutathione in dissipation of
inorganic mercury",J Appl
Toxicol,1994, 14(3): 201‑; & W.O. Berndt et
al,
"Renal glutathione and
mercury uptake", Fundam Appl Toxicol, 1985, 5(5):832‑9; & Zalups RK, Barfuss
DW. Accumulation and handling of inorganic mercury in the kidney
after coadministration with glutathione, J
Toxicol
Environ Health, 1995, 44(4): 385-99; & T.W.Clarkson et al, "Billiary secretion of glutathione‑metal
complexes", Fundam Appl Toxicol,
1985, 5(5):816‑31;
(115) (a) Biochemical Treatment of
Mental Illness and Behavior Disorders, William J. Walsh, Ph.D. Health
Research Institute, https://www.walshinstitute.org;
Minnesota Brain Bio Association November 17, 1997 ; &(b)
Walsh WJ, Isaacson Hr, Hall A, Elevated blood copper
to zinc ratios in assaultive young males, Physiol Behav. 1997 Aug;62(2):327-9;
(116) Liebert CA; Wireman J; Smith T;
Summers AO, "The impact of mercury released from dental "silver"
fillings on antibiotic resistance in the primate oral and intestinal bacterial
flora", Met Ions Biol Syst
1997;34:441-60; & (b) A.O.Summers et al, Antimicrobial
Agents and Chemotherapy,
37(4):825-834,1993; &(c) Mercury resistance among
clinical isolates of Escherichia coli. Poiata
A, Badicut I, Indres
M, Biro M, Buiuc D. Roum
Arch Microbiol Immunol. 2000 Jan-Jun;59(1-2):71-9;
& (d) Resistance of the normal human microflora to mercury and
antimicrobials after exposure to mercury from dental amalgam fillings. Edlund C, Bjorkman L, Ekstrand
J, Sandborgh-Englund G, Nord CE. Clin Infect Dis. 1996 Jun;22(6):944-50; & (e) M.Vimy et al,” Silver dental
fillings provoke an increase in mercury and antibiotic
resistant bacteria in the mouth and intestines of
primates”, APUA Newsletter, Fall, 1991.
(119) Methylmercury
induces oxidative injury, alterations in permeability and glutamine transport
in cultured astrocytes. Brain Res. 2007 Feb 2;1131(1):1-10. Yin
Z, Milatovic D, Aschner
JL, Syversen T, Rocha JB, Souza
DO, Sidoryk M, Albrecht J, Aschner M.
(126)(a)Singh I, Pahan K, Khan
M, Singh AK. Cytokine-mediated induction of ceramide production is
redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in
demyelinating diseases. J Biol Chem. 1998 Aug
7;273(32):20354-62; & Pahan K, Raymond JR, Singh
I. Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in
lipopolysaccharide- or cytokine-stimulated C6 glial cells. J. Biol. Chem. 274:
7528-7536, 1999; &Xu J, Yeh CH, et al,
Involvement of de novo ceramide biosynthesis in tumor necrosis
factor-alpha/cycloheximide-induced cerebral endothelial cell
death. J Biol Chem. 1998 Jun
26;273(26):16521-6; & Dbaibo GS, El-Assaad W, et al, Ceramide
generation by two distinct pathways in tumor necrosis factor alpha-induced cell
death. FEBS Lett. 2001 Aug 10;503(1):7-12; & Liu B, Hannun YA.et al, Glutathione regulation of neutral sphingomyelinase
in tumor necrosis factor-alpha-induced cell death.J Biol Chem. 1998 May
1;273(18):11313-20; & (b) Noda M, Wataha JC, et al, Sublethal, 2-week exposures of dental
material components alter TNF-alpha secretion of THP-1 monocytes. Dent Mater.
2003 Mar;19(2):101-5; & Kim SH, Johnson VJ, Sharma
RP. Mercury inhibits nitric oxide production but
activates proinflammatory cytokine expression in murine macrophage:
differential modulation of NF-kappaB and p38 MAPK
signaling pathways. Nitric Oxide. 2002 Aug;7(1):67-74;
& Dastych J, Metcalfe DD et al, Murine mast cells
exposed to mercuric chloride release granule-associated
N-acetyl-beta-D-hexosaminidase and secrete IL-4 and TNF-alpha. J Allergy Clin Immunol. 1999 Jun;103(6):1108-14. & (c) Tortarolo M, Veglianese P, et al, Persistent activation of p38
mitogen-activated protein kinase in a mouse model of familial amyotrophic
lateral sclerosis correlates with disease progression.. Mol Cell Neurosci. 2003
Jun;23(2):180-92.
(181) P.W.
Mathieson, “Mercury: god of TH2 cells”,1995, Clinical Exp
Immunol.,102(2):229-30; & (b) Murdoch RD, Pepys J; Enhancement of
antibody and IgE production by mercury and platinum
salts. Int Arch Allergy Appl
Immunol 1986 80: 405-11;& (d) Parronchi
P, Brugnolo F, Sampognaro
S, Maggi E. Genetic and Environmental Factors Contributing to the
Onset of Allergic Disorders. Int Arch Allergy Immunol 2000 Jan;121(1):2-9.
(194) Lu SC, FASEB J, 1999, 13(10):1169‑83,
“Regulation of hepatic glutathione synthesis: current concepts and
controversies”; & R.B. Parsons, J Hepatol, 1998, 29(4):595-602;
& R.K.Zalups
et al,"Nephrotoxicity of inorganic mercury co‑administered
with L‑cysteine", Toxicology, 1996, 109(1): 15‑29
(225) S.
Yannai et al, “Transformations of inorganic mercury
by candida albicans
and Saccharomyces cerevisiae”, Applied Envir
Microbiology,1991, 7:245-247; & N.E.Zorn et al, “
A relationship between Vit B-12, mercury uptake, and
methylation”, Life Sci, 1990, 47(2):167-73; & Ridley WP, Dizikes L, Cheh A, Wood
JM. Recent studies on biomethylation and demethylation of toxic elements. Environ Health Perspect 1977 Aug;19:43‑6 & R.E.DeSimone et al, Biochem Biophys Acta, 1973,May 28; & Yamada, Tonomura“Formation of methyl Mercury Compounds from
inorganic Mercury by Clostridium cochlearium” J Ferment Technol1972 50:159‑1660
(228) (a)A.F.Zamm,
“Removal of dental mercury: often an effective treatment for very sensitive
patients”, J Orthomolecular Med, 1990, 5(53):138-142. (22
patients); & (b)Dr. T. Rau, Paracelsus Alergy
Clinic, Lustmuhle, Switzerland, Allergies:
Causes, Clarification, Treatment; Explore, 8(4),1996,
www.explorepub.com/articles/bio‑therapy.html ; & (c) Dr. B.
Shelton, Director, The Allergy Center, Phoenix, Arizona, www.hamptonroadspub.com/main/books/excerpts/elements2.html; & (d) E. Cutler, Winning the
War against Asthma & Allergies, Delmar Learning; 1st edition (July 9,
1997)
(232) Adolph
Coors Foundation, “Coors Amalgam Study: Effects of placement and removal of
amalgam fillings”, 1995. (www) & International DAMS Newsletter, p17,
Vol VII, Issue 2, Spring 1997. (31 cases); & (b) Antero Danersund,"Dental Materials and Psychoneuroimmunology
Conference". Danderyd Hospital, 14-16
August, 1998; www.melis.org & Experimental
study on brain oxygenation in relation to tissue water redistribution and brain
oedema. Acta Neurochir
Suppl. 2000;76:279-81, Titovets
E, Nechipurenko N, Griboedova
T, Vlasyuk P.
(252) B.J.Shenker et al, Dept. of
Pathology, Univ. of Pennsylvania, “Immunotoxic
effects of mercuric compounds on human lymphocytes and monocytes: Alterations
in cellular glutathione content”, Immunopharmacol Immunotoxicol 1993, 15(2-3):273-90;
(256) D.B.Alymbaevaet al, Med Tr Prom Ekol, 6:13-15, 1995 (Russian), and Mayo Clinic,
Stomach Cancer http://www.mayoclinic.com/health/stomach-cancer/DS00301
(285) R.C.Perlingeiro et al, “Polymorphonuclear phagentosis in workers exposed to mercury
vapor”, Int J Immounopharmacology”,
16(12):1011-7,1994; & Hum Exp Toxicol
1995, 14(3):281-6; & M.L. Queiroz et al, Pharmacol Toxicol, 1994,
74(2):72-5; & (b) J.W.Albers et al, “Neurological
abnormalities associated with remote occupational elemental mercury exposure”,Ann Neurol 1988,
24(5):651-9
(302)
R.F. Kidd, Results of Dental Amalgam Removal and Mercury Detoxification,
Alternative Therapies, July 2000, vol 6, no. 4,
p49-55.
(303) Heavy Metal and Chemical Toxicity, Dietrich Klinghardt,
MD, Ph.D. www.klinghardtacadamy.com; & Mercury Toxicity
and Systemic Elimination Agents, D. Klinghardt &
J Mercola(DO), J of Nutritional and Environmental
Medicine, 2001, 11:53-62; & Amalgam Detox, Klinghardt
Academy of Neurobiology, 2008
(304) Dietary
Supplementation with Chlorella pyrenoidosa Produces
Positive Results in Patients with Cancer or Suffering from Certain Common
Chronic Illnesses, R.E. Merchant and C.A. Andre, Townsend Letter for Doctors
& Patients, Feb/Mar 2001
(314) M.Kubicka-Muranyi et al, “Systemic
autoimmune disease induced by mercuric chloride”, Int
Arch Allergy Immunol;1996, 109(1):11-20; & M.Goldman
et al,1991,“Chemically induced autoimmunity ...”,Immunology Today,12:223-;
& K. Warfyinge et al, “Systemic autoimmunity due
to mercury vapor exposure in genetically susceptible mice”, Toxicol
Appl Pharmacol, 1995,
132(2):299-309;& L.M. Bagenstose et al, “Mercury
induced autoimmunity in humans”, Immunol Res, 1999,20(1): 67-78
(338) (a)W.Y.Boadi
et al, Dept. Of Food Engineering and Biotechnology, T-I Inst of Tech., Haifa,
Israel, “In vitro effect of mercury
on enzyme activities and its accumulation in the first-trimester
human placenta”, Environ
Res, 1992, 57(1):96-106;& “In vitro exposure to mercury and cadmium alters
term human placental membrane fluidity”, Pharmacol,
1992, 116(1): 17-23; & (b)J.Urbach et
al, Dept. of Obstetrics & Gynecology, Rambam Medical Center, Haifa, Israel,
“Effect of inorganic mercury on in vitro placental
nutrient transfer and oxygen consumption”, Reprod Toxicol, 1992,6(1):69-75;& © Karp W, Gale TF
et al, Effect of mercuric acetate on selected enzymes of maternal and fetal
hamsters” Environmental Research, 36:351-358; & W.B. Karp et al,
“Correlation of human placental enzymatic activity with
trace metal
concentration in placenta”, Environ Res. 13:470- 477,1977;
& (d) Boot JH. Effects of SH‑blocking compounds on
the energy metabolism and glucose uptake in isolated rat hepatocytes. Cell
Struct Funct 1995 Jun;20(3):233‑8; & Semczuk M, Semczuk‑Sikora
A. New data on toxic metal intoxication (Cd, Pb,
and Hg in particular) and Mg status during
pregnancy. Med Sci Monit 2001 Mar;7(2):332‑340;
& (e) H.Iioka et al,
“The effect of inorganic mercury on placental amino acid
transport”, Nippon sanka Fujinka Gakkai Zasshi, 1987,
39(2): 202-6.
(369) Sterzl I, Prochazkova
J, Stejskal VDM et al, Mercury and nickel allergy: risk factors in fatigue and
autoimmunity. Neuroendocrinology
Letters 1999; 20:221-228; & Prochazkova J, Sterzl
I, Kucerova H, Bartova
J, Stejskal VD; The beneficial effect of amalgam replacement on health in
patients with autoimmunity. Neuro Endocrinol Lett. 2004
Jun;25(3):211-8. http://www.melisa.org/pdf/Mercury-and-autoimmunity.pdf
(404) M. E.
Godfrey, Candida, Dysbiosis and Amalgam. J. Adv. Med. vol
9 no 2 (1996); & Romani L, Immunity to Candida Albicans:
Th1,Th2 cells and beyond. Curr Opin Microbiol
1999, 2(4):363-7; & Alfred V. Zamm. CANDIDA ALBICANS THERAPY: Dental mercury
removal, an effective adjunct. J. Orthmol. Med.
v1#4 pp261-5 (1986)
(405) Stejskal J, Stejskal
V. The role of metals in autoimmune diseases and the link to neuroendocrinology Neuroendocrinology Letters, 20:345‑358, 1999. www.melisa.org/
(406) Hemorrhagic Colitis
Secondary to Acute Elemental Mercury Vapor Poisoning, Laura
A Heise, Brant M Wagener, Jennifer R
Vigil, Mohamed Othman and Parsa Shahinpoor, Am
J Gastroenterol. 2009 Feb;104(2):530-1. Epub 2009 Jan
13.
(410) J.R. Cade et al, Autism and schizophrenia linked to
malfunctioning enzyme for milk protein
digestion. Autism, Mar
1999.
(411) Puschel G, Mentlein R, Heymann E, 'Isolation and characterization of dipeptyl peptidase IV from
human placenta', Eur J Biochem 1982
Aug;126(2):359-65; & Kar NC, Pearson CM. Dipeptyl Peptidases
in human muscle
disease. Clin Chim
Acta 1978; 82(1-2): 185-92; & Seroussi
K, Autism and Pervasive Developmental
Disorders , 1998, p174,etc.;
& Shibuya-Saruta H, Kasahara Y, Hashimoto Y. Human serum
dipeptidyl peptidase IV (DPPIV) and its unique properties. J Clin Lab Anal. 1996;10(6):435-40; & Blais
A, Morvan-Baleynaud J, Friedlander G, Le Grimellec C. Primary culture of rabbit proximal tubules as
a cellular model to study nephrotoxicity of xenobiotics. Kidney Int. 1993
Jul;44(1):13-8
(412) (a) Moreno-Fuenmayor H, Borjas L, Arrieta A,
Valera V, Plasma excitatory amino
acids in autism. Invest Clin
1996,37(2):113-28;& Carlsson ML. Is infantile autsim a hypoglutamatergic disorer? J Neural Transm 1998,
105(4-5): 525-35. & (b)Rolf LH, Haarman FY, Grotemeyer KH, Kehrer H. Serotonin and
amino acid
content in platelets of autistic children. Acta Psychiatr
Scand 1993, 87(5): 312-6; &
(c)Naruse H, Hayashi
T,
Takesada M, Yamazaki
K. Metabolic changes in aromatic amino acids and monoamines in
infantile autism and
a new related treatment, No To Hattatsu, 1989, 21(2):181-9;
(469) M.M. van Benschoten, ““Acupoint Energetics of Mercury Toxicity and
Amalgam Removal with Case Studies,”” American Journal of Acupuncture, Vol. 22,
No. 3, 1994, pp. 251-262; & M.M. Van Benschoten and Associates, Reseda, Calif. Clinic;
http://www.mmvbs.com/
(470) Dr. Garth
Nicholson, Institute for Molecular Medicine, Huntington Beach, alif.,
www.immed.org & Michael Guthrie, R.Ph. ImmuneSupport.com 07‑18‑2001 Mycoplasmas
– The Missing Link in Fatiguing Illnesses, www.immed.org
& New
Treatments
for Chronic
Infections Found in Fibromyalgia Syndrome, Chronic Fatigue Syndrome, Rheumatoid Arthritis, and
Gulf War Illnesses,
(479) Amphotericin B, HgCl2 and Peritoneal
Transport in Rabbits, Zweers
MM, Douma CE, van der Wardt
AB,
Krediet RT, Struijk DG.
Department of
Nephrology, Academic Medical Center, Amsterdam,
The Netherlands. Accepted Abstracts : The 3rd
European Peritoneal Dialysis Meeting ‑‑ 5‑7 April
1998, Edinburgh, U.K.; & Structural basis of aquaporin
inhibition by mercury. J Mol Biol. 2007 May
4;368(3):607-17; Savage DF, Stroud RM; & Mercury chloride
decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell.
2008 Jan 2; Yukutake Y, Tsuji
S, Hirano Y, Adachi T, Takahashi T, et al
(480) Life Enhancement
Foundation (MDs), Disease Treatment and Prevention, Expanded
5th Edition, 2013.
(481) Vitamin Research
News, studies in various volumes, see achieve, www.vrp.com
(485) Dr. Hulda Clark, The Cure for all Diseases, New
Century Press,2000, www.drclark.net (amalgam replacement and treatment for
parasites/bacteria)(U.S. CDC confirms parasites common in those with chronic
immune conditions) & U.S. Center for Disease Control, Parasites(widespread
exposures), www.dpd.cdc.gov/dpdx/HTML/Para_Health.htm ;www.cdc.gov/ncidod/diseases/list_parasites.htm
(487) Vitamin Research
News, Vol 23, No. 1, Jan 2009, Gastrointestinal Support, p12-17.
(506) Leistevuo J, Pyy L, Osterblad M, Dental
amalgam fillings and the amount of organic mercury in human saliva. Caries
Res 2001 May‑Jun;35(3):163‑6; & Leistevuo J et al., Dental amalgam fillings and the amount
of organic mercury in human saliva, Corks Res, 35(3):163-6 (2001 May-Jun)
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