Cancer Connection to Mercury, Toxic Metals, and Dental Cavitations, with information on cancer treatment B.Windham (Ed)
As seen here, in addition to cancers caused by radiation, pesticides, and other organic chemicals, toxic metals such as mercury have major effects on weakening the immune system and facilitating cancer (17). Studies have documented that most people have significant accumulation of toxic metals and pesticides and need to test (6) and detox: (Pectasol, chlorella, Berberine, etc.)
Medical labs, medical studies, and government agencies have documented that dental amalgam is the largest source of mercury in most people who have several amalgam fillings (1,500). Fish, vaccinations, and occupational exposure such as dental offices are other sources of significant mercury exposures. A nationwide survey found that over 22 percent of those tested for mercury levels in
the hair had dangerous levels higher than the U.S. EPA mercury health reference level (2). Toxic metal levels were measured in 6-24 hours urinary samples of 100 randomly chosen patients with chronic conditions at the Institute of Integrative Medicine following a combined EDTA/DMSA provocation challenge. Over 70% had levels of lead, arsenic, mercury, or cadmium outside the Laboratory Reference Level (571).
Dr. Simon Yu(21), Dr. T. Levy(22), Dr. George Meinig (24), and many of the other doctors and dentists referenced here(21-33,52) point out that millions of patients have medically unexplained symptoms/conditions and suffer and die from conditions like Cancer, ALS, MS, ALZ, Parkinson’s, CFS, etc. -that could be cured or significantly improved, but have underlying immune system disabling factors that usually include parasitic infections, dental infections (root-canaled teeth, jaw- bone cavitation infections, gum disease), toxic metal toxicity or other toxins, nutritional factors, etc. These conditions can be tested for and treated by knowledgeable doctors or dentists and usually improve (21-33), but most doctors and dentists in the U.S. do not have proper training to know what to test for or how to test for chronic conditions underlying immune disabling problems (21-33,52), etc.).
Dental amalgams have been documented to be the largest source of mercury in most people who have amalgam fillings, and also more on average than those without amalgams. The studies also document that much of the exposure is organic mercury since oral and intestinal bacteria convert inorganic mercury to organic mercury. Galvanism in the mouth of those with dental amalgam or gold crowns or mixed metals in the mouth through the battery effect causes electrical currents and metals corrosion in the mouth that greatly increase mercury and metals exposure and toxicity effects. Also EMF and wi-fi and microwaves have been documented to increase mercury vapor release and exposure in those with amalgam fillings, increasing damages from mercury and metals toxicity.
A large U.S. Centers for Disease Control epidemiological study, NHANES III, found that those with more amalgam fillings (more mercury exposure) have significantly higher levels of chronic health conditions (543). The conditions in which the number of dental amalgam surfaces were most highly correlated with disease incidence were MS, epilepsy, migraines, mental disorders, diseases of the nervous system, disorders of the thyroid gland, cancer, and infectious diseases (543,500). Large numbers of patients with many such chronic conditions recovered or significantly improved after amalgam replacement. For many chronic conditions, clinical studies found the majority recovered or improved after proper amalgam replacement with proper immune support.
Mercury and other toxic metals such as copper and lead cause breaks in DNA (4,8,38,41,42,197,272,296,500), and also have synergistic effects with x-rays (296) and EMF. Several toxic metals, including arsenic, cadmium, chromium, and nickel, have been documented to be carcinogenic (5,496,497,498). Some of the mechanisms by which toxic metals such as mercury causes cancer have been documented by medical clinical studies (4,5,8,17,18,19,100-102,500). A study on mercury tested at concentrations comparable with its occurrence as environmental pollutant showed that Hg (II) elicits a prooxidative state in keratinocytes linked to inhibition of gap junction-mediated intercellular communication and proinflammatory cytokine production (8). These combined effects appear to on one hand isolate cells from tissue-specific homeostasis promoting their proliferation and on the other hand tamper the immune system defense/surveillance checkmating the whole organism. Thus, mercury appears be an example of an epigenetic tumor promoter or, further expanding this concept, a "metagenetic" effector. Studies found mercury occupational exposure had a significant association with lung and liver cancer (20).
Low non-cytotoxic levels of mercury induce dose dependent binding of mercury to DNA and significantly increased cell mutations (142,4,18,500) and birth defects (197,38,105). Compared to control, a total of 658 aberrant RNA alternative splicing (AS) events were observed after MeHg exposure (18). Proteomics and RNA-seq results also demonstrated that mercurychloride (HgCl2) influenced the expression levels of several RNA splicing related proteins and 676 AS events compared to control. These results suggested that RNA splicing could be a new molecular mechanism involved in MeHg and HgCl2 neurotoxicity (18). Numerous studies showed that lead and mercury induce cancer in humans and also in animals, in vitro experiments with cultured cells indicate that they cause DNA damage via different molecular mechanisms including release of reactive oxygen species and interactions with DNA repair processes (19). Also, in most human studies, positive results were obtained in micronucleus MN tests with lymphocytes (all 15 occupational studies with lead yielded positive results, with mercury 6 out of 7 investigations were positive). For cadmium, there is clear evidence that it causes cancer in humans; however, induction of chromosomal damage was only seen in high dose experiments with mammalian cells while results of human studies yielded conflicting results (only in 2 of 5MN trials with humans), positive findings were reported). Possibly, non-genotoxic mechanisms such as inhibition of apoptosis and interaction with signaling pathways account for the carcinogenic properties of cadmium species. The findings of MN studies with lead and mercury are in excellent agreement with results which were obtained with other endpoints (e.g. chromosomal aberrations and comet formations) In addition to effects on DNA, mercury also promotes cancer in other ways. Mercury by its effect of weakening the immune system contributes to increased chronic diseases and cancer (17,91,180,228a,237,239,222,234,355,369, 405,500,530,543,570, 35,38,40, etc.).
Nobel Prize winner Dr. Otto Warburg determined that cancer has only one prime cause (581). It is the replacement of normal oxygen respiration of the body's cells by an anaerobic [i.e., oxygen-deficient] cell respiration. Porphyrins are precursors to heme, the oxygen carrying component of blood. Mercury inhibits the conversion of specific porphyrins to heme (84,35,201,539,500). Mercury has been documented to bind to oxygen carrying sites in the blood, reducing a person’s available oxygen supply. (232,233,570,571,500). Mercury binds with hemoglobin, which is located inside the red blood cell and carries oxygen for transport to tissues. Mercury bound to hemoglobin results in less oxygen carrying capacity of the red blood cell and therefore less oxygen will reach the tissues. The body senses the need for more oxygen and may attempt to compensate for this by increasing the production of hemoglobin. A normal or increased hemoglobin level combined with symptoms of lack of oxygen (fatigue, weakness, appearing pale, rapid heart rate, shortness of breath, etc.) could indicate mercury toxicity. But this can confuse some doctors since the patient seems like they are anemic but in fact the blood counts seem fine (233). A new well documented book has more information on causes of cancer and effective natural treatments for cancer (560), including the toxic teeth connection.
At the energetic-molecular level, the boundary between health and the state of absence of health is marked by oxidosis, acidosis, and dysoxygenosis (dysox). (571,581) There is but one fundamental difference between a healthy cell and an unwell cell: a healthy cell has a well preserved oxygen homeostasis. A healthy cell utilizes oxygen well, without incremental oxidative stress (oxidosis) and without accumulating organic acids (acidosis). In contrast, an unwell cell cannot utilize oxygen well and gets clogged up with Krebs cycle metabolites and other organic acids. At the bioenergetic cellular level, all inflammatory, autoimmune, and neurodegenerative disorders are caused by the oxygen disorder (dysfunctional oxygen utilization) caused by cellular toxicity in the cells.
Mercury from dental amalgams appears to be one of the most, if not the most, potent disrupters of oxygen metabolism in the oral cavity (571,233). Other such disrupters are thioethers related to root canal teeth or cavitations and other microbial toxins. Those factors also alter the local conditions that either inhibit or foster microbial growth, so facilitating biofilm formation. Such dynamics seem to play crucial roles in the pathogenesis of systemic disorders rooted in the oral cavity. The crucial importance of oral toxicity in triggering, amplifying, and perpetuating systemic inflammatory and infectious disorders has largely been ignored by most doctors and dentists. The presence of the cellular dysox state can be readily documented by the measurement of 24-hour urinary excretion of organic acids.
Mercury has been found to bind oxygen binding sites in hemoglobin, thus reducing access to oxygen carried by the blood (232,233,35,582). Oxyhemoglobin saturation levels in venous blood should be at least 60% for normal levels. The majority of a group of 27 patients with amalgam dental fillings suffering from chronic fatigue whose oxyhemoglobin was tested had lower than normal oxyhemoglobin saturation levels (232,35). After amalgam replacement the majority of those with oxyhemoglobin levels equal to or less than 45% had significant increases in oxyhemoglobin saturation levels, on average about 15%. Heme is used for 2 main functions, in red blood cells and in production of energy by enzymatic processes in the ATP cytochromeoxidaze system. Mercury and other toxics have been documented to block these enzymatic processes, resulting in dumping porphyrin wastes into the urine rather than completing the proper heme functions. The level of these porphyrins in the urine can be measured by a standard urine test, the fractionated porphyrin test, and indicate the level of toxic disruption of the basic enzymatic ATP production process. The majority of the patients in the study had high levels of porphyrins in the urine, which decreased significantly after amalgam replacement. This has also been confirmed by other studies (260,233).
Mercury from amalgam binds to the -SH (sulfhydryl) groups, resulting in inactivation of sulfur and blocking of enzyme functions such as cysteine dioxygenase (CDO), gamma‑ glutamyltraspeptidase (GGC) and sulfite oxidase, producing sulfur metabolites with extreme toxicity that the body is unable to properly detoxify (34,111,114,405), along with a deficiency in sulfates required for many body functions. Sulfur is essential in enzymes, hormones, nerve tissue, and red blood cells. These exist in almost every enzymatic process in the body Mercury also blocks the metabolic action of manganese and the entry of calcium ions into cytoplasm (333). Mercury from amalgam thus has the potential to disturb all metabolic processes (33,35,60,111,114,180,181,194,333,405,500). Mercury is transported throughout the body in blood and can affect cells in the body and organs in different ways causing numerous types of chronic health conditions including blood conditions and cancer.
Mercury has a high affinity for and readily binds to selenium and to the thiol or sulfhydryl (sulfur/hydrogen combination) sites in living tissues. The higher the attraction between chemicals or elements, the stronger they bond to each other, and the harder it is to separate them. The thiol combination is extremely common in the human body. It occurs as part of certain amino acids, which are building blocks of proteins. Since these amino acids are used to build cells, hormones, and enzymes, the occurrence of the thiol combination in the body is not only common but extremely important, as normal function is altered. There are several thiol sites in the hemoglobin molecule in the red blood cells used to transport oxygen throughout the body. Mercury accumulates in red blood cells in humans and other animals. When mercury attaches to the thiol sites, the hemoglobin can't carry as much oxygen as it could. This results in decreased availability of oxygen (hypoxia) that is needed by all body cells and explains one way that mercury toxicity can cause chronic fatigue symptoms and other effects of low oxygen levels in the cells.
Toxic metal exposure’s adverse influence on thyrocytes can play a major role in thyroid cancer etiology (144,500). Among those with chronic immune system problems with related immune antibodies, the types showing the highest level of antibody reductions after amalgam removal include thyroglobulin and microsomal thyroid antigens (91,369). Similar results regarding mercury have been found for treatment of other types of cancer. Studies have found conventional chemotherapy (alone) to be only a little more effective than no treatment and clinical cases have demonstrated that detoxification and nutritional support can be effective in treating multiple myeloma (550,7,6) and other cancers (486,530,572,35,228a). For more on treating cancer see “Causes of Cancer and Natural Treatments”.
Exposure to mercury vapor causes decreased zinc, selenium, and methionine availability, depresses rates of methylation, and increased free radicals- all factors in increased susceptibility to cancer and other chronic conditions (14,17,34,38,43,143,144,180,237,239,251,256,283,530). Amalgam fillings have also been found to be positively associated with oral cancer (206,251,403). Mercury from amalgam fillings has also been found to cause increase in white blood cells and in some cases to result in leukemia (35,180). There is evidence that some forms of leukemia are abnormal response to antigenic stimulation by mercury or other such toxics, and total dental revision including removal of amalgam has led to remission very rapidly in some cases (35,38,180,239,500). Among a group of patients testing positive as allergic to mercury, low level mercury exposure was found to cause adverse immune system response, including effects on vitro production of tumor necrosis factor TNF alfa and reductions in interleukin-1. (126,131,152)
Mercury has been found to cause decreased sperm volume and motility, increased sperm abnormalities and spontaneous abortions, increased uterine fibroids/ endometritis, and decreased fertility in animals (4,104,105,162) and in humans (9,10,23,31,37,105,146,159, 395,433,27,35,38). In studies of women having miscarriages or birth defects, husbands were found to typically have low sperm counts and significantly more visually abnormal sperm (393). It's now estimated that up to 85 per cent of the sperm produced by a healthy male is DNA-damaged (433). Abnormal sperm is also being blamed for a global increase in testicular cancer, birth defects, and other reproductive conditions.
There are extensive documented cases (many thousands) where removal of amalgam fillings led to cure or significant improvement of serious health problems such as oral keratosis (pre cancer) (87,251), cancer (breast, leukemia, etc.) (35,38,94,180,228a,469,486,487,500, 530).
Some studies have found increased risk of lung, kidney, brain, and CNS system cancers among dental workers (34,99,143,283). Other studies reviewed found increased rates of brain cancer related to mercury exposure (193,383,328). Dr. Max Daunderer's serial biopsies on malignant tumors in-patients that had amalgam fillings found toxic metals contained in amalgam in the tumor. The concentration is highest in the center of the tumor (malignant melanoma, brain cancer, bladder, stomach, colon and tongue cancer). (570) An occupational study found that Occupations with likely exposure to mercury or arsenic such as dental nurses displayed increased risk of melanoma (14). For tests & detox, see(6).
Some studies have also found persons with chronic exposure to electromagnetic fields (EMF) to have higher release of mercury from dental amalgam, higher levels of mercury exposure and excretion (28,251c) and higher likelihood of getting chronic conditions like ALS (526) and Alzheimers (251c) and cancer (546).
Mercury causes significant destruction of stomach and intestine epithelial cells, resulting in damage to stomach lining which along with mercury’s ability to bind to SH hydroxyl radical in cell membranes alters permeability (338,405,35,21c) and adversely alters bacterial populations in the intestines- causing leaky gut syndrome with toxic, incompletely digested complexes in the blood(222,228b,35) and accumulation of heliobacter pylori, a suspected major factor in stomach ulcers and stomach cancer (256) and candida albicans (404), as well as poor nutrient absorption.
From extensive clinical experience the spread of cancer has been commonly found to be related to fungal/Candida incidence, and treating Candida through blood alkalinity balance and reduction of toxic metals body level has been found to reduce the spread of cancer(233a). Such treatments also increase oxygen supply to the cells. (580). An anaerobic environment favors the development of yeast infections and cancer, since yeast is a fermenting spore and cancer is a fermenting cell rather than a normal respiratory (oxygen using) cell.
Mercury has a symbiotic relation to Candida in the body and promotes the proliferation of Candida. Mercury impairs the body�s ability to kill Candida albicans by impairment of the lytic activity of neutrophils and myeloperoxidase in workers whose mercury excretion levels are within current safety limits (233,285,404). Immune Th1 cells inhibit Candida by cytokine related activation of macrophages and neutrophils. Development of Th2 type immune responses deactivate such defenses(404b,181). Mercury inhibits macrophage and neutrophil defense against Candida by its effects on Th1 and Th2 cytokine effects (181,285,404b). Candida also methylates inorganic mercury to the highly toxic methyl mercury form which like mercury vapor readily crosses the blood-brain barrier, causes neurological damage, and weakens the immune system (225,405). Candidiasis is often observed in immunocompromised individuals such as those with toxic metal exposures, especially those who are found by test to be immune reactive to mercury or other toxic metals (60,235,405). Amalgam replacement cures or significantly improves Candida (404,222,35, etc.),
Nickel and beryllium are 2 other metals commonly used in dentistry that are very carcinogenic, toxic, and cause DNA malformations (35,456,560,13). Nickel ceramic crowns, root canals and cavitations have also been found to be a factor in some breast cancer and other cancers and some have recovered after TDR, which includes amalgam replacement, replacement of metal crowns over amalgam, nickel crowns, extraction of root canaled teeth, and treatment of cavitations where necessary (35,200,228a,486,530,560). Nickel depletes intracellular ascorbate, which leads to the inhibition of cellular hydroxylases, manifested by the loss of hypoxia-inducible factor (HIF)-1alpha and -2alpha hydroxylation and hypoxia-like stress (13). Proline hydroxylation is crucial for collagen and extracellular matrix assembly as well as for assembly of other protein molecules that have collagen-like domains, including surfactants and complement. Thus, the depletion of ascorbate by chronic exposure to nickel could be deleterious for lung cells and may lead to lung cancer.
Root canals and cavitations also facilitate cancer by effect on immune system. (570,560) As more information is accumulated it is apparent that these areas (bone cavitations) of chronic infection in the craniofacial area are very real and the probable cause of multiple painful conditions in the head, neck and tooth area. (571) This is due in part to the progressive loss of vascularity in the jaw bones and associated structures. This allows the pathogenic anaerobic microbial population to exist and create a chronic infected, inflamed area. This area is effectively isolated from the circulatory system which is responsible for delivering any anti-microbial medications to the infected area. These types of bone cavities have also been shown to have accumulations of toxic heavy metals, as well as the pathogenic microbes. There have been considerable numbers of cases documented of recovery from cancer after dealing with oral infections such as root canals and cavitations. (571,560, etc.) (T: test root canal teeth toxicity & extract and treat if needed)
Prostate cancer is the most commonly diagnosed cancer in men in the US. Over 300,000 new prostate cancer cases are diagnosed annually, constituting about 30% of all new male cancer cases, and more than 40,000 men die from the disease each year (490). Both breast cancer and prostate cancer are hormonally responsive, containing estrogen, androgen, and progesterone receptors. Genetic susceptibility and environmental factors that promote the sequence that results in clinical prostate cancer have been found to be factors in prostate cancer, with environmental factors being the larger with exposures in early life facilitating later effects. Low-level developmental exposures to substances that modulate endocrine activity can have life- long impacts if the exposure occurs during window(s) of unique vulnerability.
Cadmium and arsenic are known human carcinogens and are linked to prostate & breast cancer in epidemiologic and laboratory animal studies. Arsenic has also been shown to be a factor in Lung cancer, Bladder cancer, Skin cancer, digestive tract, , , urothelial, and and systems (496). Cadmium and arsenic have also been found to be associated with lung cancer (491e,494c, etc.) Food, cigarette smoke, and well water are 3 sources of cadmium exposure. Cadmium has been found to be a cause of breast, lung, prostate, nasopharynx, pancreas, kidney, renal, & bladder cancer (497). T: test & detox (6, Pectasol, etc. )
A substantial number of environmental pollutants, such as polychlorinated biphenyls, dioxins, polycyclic aromatic hydrocarbons, phthalates, bisphenol A, pesticides, herbicides, alkylphenols and heavy metals (arsenic, cadmium, lead, mercury), have been shown to disrupt endocrine function. (100) diabetes, obesity, metabolic diseases and developmental problems These compounds can cause reproductive problems by decreasing sperm count and quality, increasing the number of testicular germ cells and causing male breast cancer, cryptorchidism, hypospadias, miscarriages, endometriosis, impaired fertility, irregularities of the menstrual cycle, and infertility. (100) Endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals (101).
Dietary factors such as consumption level of red meat, refined carbohydrates, and environmental exposures to estrogenic chemicals have been found to increase the incidence of both prostate and breast cancer (490,560,100,101). Many occupational studies show an increased incidence of prostate cancer incidence and/or mortality among farmers and pesticide applicators(102). One in vitro study of human prostate cancer cells showed that several organochlorine pesticides, a pyrethroid, and a fungicide each caused proliferation of androgen-dependent cancer cells (490). Another environmental estrogen, bisphenol A (BPA-a component of epoxy resins, polycarbonate plastic, and dental sealants to which the general population is exposed at low levels), has been found to affect the prostate and be related to development of prostate cancer (490).
The toxic metals mercury, lead, cadmium, copper, cobalt, nickel, lead, aluminum, and tin have been found to have reproductive and endocrine system disrupting effects (10,12,100), as well as synergistic effects. The ability of metals to activate estrogen receptor-alpha (ERalpha) was measured in the human breast cancer cell line, MCF-7. Similar to estradiol, treatment of cells with the divalent metals copper, cobalt, nickel, lead, mercury, tin, and chromium or with the metal anion vanadate stimulated cell proliferation; by day 6, there was a 2- to 5-fold increase in cell number. The metals also decreased the concentration of ERalpha protein and mRNA by 40-60% and induced expression of the estrogen-regulated genes progesterone receptor and pS2 by1.6- to 4-fold. Furthermore, there was a 2- to 4-fold increase in chloramphenicolacetyltransferase activity after treatment with the metals in COS-1 cells transiently cotransfected with the wild-type receptor and an estrogen-responsive chloramphenicol acetyltransferase reporter gene. The ability of the metals to alter gene expression was blocked by an antiestrogen, suggesting that the activity of these compounds is mediated by ER alpha (10,12). Aluminum in the form of aluminum chloride or aluminium chlorhydrate, which are used in antiperspirants, can interfere with the function of oestrogen receptors of MCF7 human breast cancer cells both in terms of ligand binding and in terms of oestrogen-regulated reporter gene expression (12).
As previously seen, there are several estrogenic or carcinogenic metals (100, etc.), and clinical experience has found metals detoxification to be beneficial in cancer case treatment(6). There are also diet measures and supplements that have been found to be beneficial in preventing or treating cancer. A comprehensive and well documented summary of natural cancer treatments clinically documented to be effective in treating cancer is Outsmarting Your Cancer (560). Many effective options are covered, with considerable detail and documentation. Another source of such information in Cancer and Natural Treatments for Cancer
Vit K2, Vit D, zinc, and green tea have all been found to be effective in preventing or treatment of prostate cancer and other types of cancer(501-503,493a). Black tea theaflavins have been found to be effective at prevention of cigarette smoke-induced lung damage and cancer (504), and have demonstrated effectiveness in switching off the genes involved in many types of cancer (505). Studies have shown theaflavin supplementation significantly reduces levels of inflammatory cytokines such as TNF-alpha, Il-6, Il-8, and C-reactive protein; and lowered rates of production of inflammation-generating trasnscription factor NF-kB, cytokine generating COX-2, and the adhesion molecule ICAM-1(506). Vitamin K2 has been shown to induce apoptosis in leukemia cells in vitro and inhibitory effects against myeloma and lymphoma, as well as being effective at reducing liver cancer in patients with hepatitis B or C(known risk factors for liver cancer), and also to be effective at reducing rate of re-occurrence of liver cancer in liver cancer patients in remission(506). Apatone (Vit C & Vit K3) was demonstrated to significantly delay cancer progression in a group of end stage prostate cancer patients.
Patients with advanced cancer have been found to be vitamin K deficient and it is recommended to monitor levels and supplement where needed (506). Several studies found evidence of benefit of intravenous Vit C in treatment of cancer (15). A connection between cancer and fungus/candida has been demonstrated and many types of cancers have been successfully treated using sodium bicarbonate in the treatment (551,552). Adding ¼ teaspoon of sodium bicarbonate to morning coffee has been suggested by doctors as preventative. Magnesium and Iodine have also been found beneficial in treating cancer (552) and flax oil with cottage cheese which addresses common digestive problems that can be related to cancer (553). Supplementation with chlorella has been found to result in beneficial effects when used in cancer patients or for other chronic conditions such as ulcerative colitis, hypertention, or Fibromyalgia (572). Doctors such as D. Klinghardt have suggested that the mechanism by which chlorella improves treatment of such conditions is metals detoxification, which is the main mechanism of action of chlorella.
People who drink two or more high fructose syrup sweetened soft drinks a week have a much higher (87%) risk of pancreatic cancer. The high levels of sugar in soft drinks may be increasing the level of insulin in the body, which the authors think contributes to pancreatic cancer cell growth (495).
(1) Documentation of the average level of mercury exposure from dental amalgam fillings, DAMS Intl,
(2) An Investigation of Factors Related to Levels of
Mercury in Human Hair, Environmental Quality
Institute, October 01, 2005, Greenpeace Report
(3) Mercury in Pancreatic Cells of People with and without Pancreatic Cancer, Int J Environ Res Public Health, 2020 Dec 2;17(23):8990. https://pubmed.ncbi.nlm.nih.gov/33276658/
(b) Toxic metals show evidence of carcinogenic and estrogenic properties. Epidemiology, 2019 Jan;30(1):20-28. 2019 Jan;30(1):20-28. https://pubmed.ncbi.nlm.nih.gov/30198937/ &
(c) Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines, Oxid Med Cell Longev, 2017;2017:7028583. https://pubmed.ncbi.nlm.nih.gov/29430283/
(4) Lee IP, Effects of Mercury on Spermatogenisis, J
Pharmacol Exp Thera 1975, 194(1);171- 181; & Ben-Ozer
EY Rosenspire AJ, et al, Mercuric chloride damages
cellular DNA by a non-apoptotic mechanism. Mutat Res.
2000 Oct 10;470(1):19-27; & Ogura H, Takeuchi T,
Morimoto K, A comparison of chromosome aberrations and
micronucleus techniques for the assessment of
the genotoxicity of mercury compounds in human blood
lymphocytes. Mutat Res 1996 Jun;340(2‑3):175‑82
(5) Metal ions and carcinogenesis, Durham TR, Snow ET.,
EXS. 2006;(96):97-130; & (b) Estrogen-like activity of metals in MCF-7
breast cancer cells. Martin MB, Reiter R, Pham T, Avellanet YR, Camara J,
Stoica A, Endocrinology. 2003 Jun;144(6):2425-36, & (c) Aluminium,
antiperspirants and breast cancer. Darbre P D., Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, P.O. Box 228, Whiteknights, Reading, RG6 6AJ, UK. J Inorg Biochem. 2005 Se p;99(9):1912-9, & (d) Ascorbate depletion: a critical step in nickel carcinogenesis? Salnikow K, Kasprzak KS., Laboratory of Comparative Carcinogenesis, Building 538, Room 205 E., National Cancer Institute at Frederick/NIH, Frederick, MD 21702, USA., Environ Health Perspect. 2005 May;113(5):577-84. & (e) Cutaneous melanoma in Swedish women: Occupational risks by anatomic site. Perez-Gomez B, B, Aragones, Lopez-Abente G, PollanM, Cancer and Environmental Epidemiology Section, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. Am J Ind Med. 2005 Oct;48(4):270-81, & (f) Increased levels of transition metals in breast cancer tissue. Ionescu JG, Novotny J, Stejskal VD, Latsch A, Blaurock-Busch E, Research Department of Spezialklinik Neukirchen, Neukirchen, Germany. Neuro Endocrinol Lett. 2006 Aug 5;27(Suppl1). & (g) Biliary heavy metal concentrations in carcinoma of the gall bladder: case-control study, Shukla VK et al, Departments of Surgery and Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India, British Medical Journal 1998;317:1288-1289 http://www.melisa.org/abstracts.php#1
& (b) Take Charge of Your Health (Testing & Chelation of Heavy Metals) - Dr. Chris Shade - CEO of Quicksilver Scientific https://s115.podbean.com/pb/1860a0ddeed2ad45db31477355f265e8/60103875/data1/fs48/6936790/uploads/Take_Charge_1218208ati1.mp3?pbss=f02615a5-91d0-5c11-8e0e-81cca9f7c721
(8) Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines. Zefferino R, PiccoliC, et al; Oxid Med Cell Longev. 2017; 2017: 7028583.
(9) Heavy Metals and Fertility, J of Toxicology and
Environmental Health, Part A, 54(8):593-611, 1998;
Gerhard I, Monga B, Waldbrenner A, Runnebaum B; &
(c) Impact of heavy metals on hormonal and immunological
factors in women with repeated miscarriages, Hum Reprod
Update -1998 May;4(3):301‑309; Gerhard I, Waibel S,
Daniel V, Runnebaum B,
(10) Estrogen-like activity of metals in MCF-7 breast cancer cells. Martin MB, Reiter R, et al, Endocrinology. 2003 Jun;144(6):2425-36; & Dr.T. Colborn, D.Dumanoski, JP Myers (Ed.), Our Stolen Future Dutton Books, NY, 1996;
(11) Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium. Drasch G, Schopfer J, Schrauzer GN. Biol Trace Elem Res. 2005 Feb;103(2):103-7.
(12) Aluminum, antiperspirants and breast cancer. Darbre PD., J Inorg Biochem. 2005 Se p;99(9):1912-9.
(13) Ascorbate depletion: a critical step in nickel carcinogenicis? Salnikow K, Kasprzak KS., Environ Health Perspect. 2005 May;113(5):577-84.
(14) Cutaneous melanoma
in Swedish women: Occupational risks by anatomic site. Perez-Gomez B, Aragones N, et al, Am J Ind Med. 2005
(15) Intravenously administered vitamin C as cancer therapy: three cases. Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M., CMAJ. 2006 Mar 28;174(7):937-42; & Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use, Padayatty, et al. Ann Intern Med. 2004 Apr 6;140(7):533-; & Orthomolecular oncology review: ascorbic acid and cancer 25 years later, Gonzalez MJ, Miranda-Massari JR et al, Integr Cancer Ther. 2005 Mar;4 (1):32-44.
(16) Increased levels of transition metals in breast cancer tissue. Ionescu JG, Novotny J, Stejskal VD, Latsch A, Blaurock-Busch E, Eisenmann-Klein M, Neuro Endocrinol Lett. 2006 Aug 5;27 (Suppl1)
(17) Environmental Mercury and Its Toxic Effects, J Prev Med Public Health. 2014 Mar; 47(2): 74–83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988285/
(18) Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses. Li Y, He B, Liu QS et al; Environ Pollut. 2018 Jul;238:213-221.
(19) Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium. Nersesyan A, Kundi M et al; MutatRes. 2016 Oct - Dec;770(Pt A):119-139.
(20) Mortality and cancer incidence in chloralkali workers exposed to inorganic mercury; , BMJ, Occup Environ Med, http://dx.doi.org/10.1136/oem.47.2.99; & (b) Cancer occurrence among European mercury miners, Cancer Causes & Control, 9, 591–599(1998) https://link.springer.com/article/10.1023/A:1008849208686
(21) Impact of Endodontically Treated Teeth on Systemic Diseases, Dentistry 2018, 8:3 Johann Lechner and Volker von Baehr; & (c) THE ROOT CANAL AND BREAST-CANCER CONNECTION, AliReza PaNahPouR,D.D.s. , https://iaomt.org/wp-content/uploads/Unit-9-REQUIRED-Accred..pdf
(22) THE ROOTS OF DISEASE, DR. T LEVY, & HIDDEN EPIDEMIC, SILENT ORAL INFECTIONS CAUSE MOST HEART ATTACKS AND BREAST CANCER, DR. T LEVY, 2017.
(23) Toxic Root Canals, Dr. T. Levy, The Toxic Tooth;& Dr. J. Mercola, Root Canals Linked to Heart Disease and Inflammatory Conditions,; & TOXIC BACTERIA IN TEETH CONTRIBUTES TO ILLNESS THROUGHOUT THE BODY,
(24) ROOT CANAL COVERUP, DR. G.MEINIG DDS; & HTTPS://WWW.FOODMATTERS.COM/ARTICLE/ROOT-CANAL-COVER-UP-EXPOSED: & WESTON PRICE FINDINGS,
(25) Cancer/Root Canals, https://www.cancertutor.com/advdental/
(26) (a) Root Canals & Cancer (issels, diamond,huggins)
http://www.whale.to/d/root2.html; & (b) Many cancer doctors in Europe and elsewhere urge removal of root canal teeth before cancer fighting treatments are administered. http://www.annieappleseedproject.org/dentalissues.html; &
(c) The Relationship Between Root Canals and Cancer, Independent Cancer Research Foundation, &(d) Dr. Robert Kulacz's The Roots of Disease: Connecting Dentistry and Medicine, Root Canals and Cancer, (see29-31)
& (e) Cancer Care Expert Details-Root Canal Case Studies :
& (f) Central (intraosseous) adenoid cystic carcinoma of the mandible: report of a case with periapical involvement. J Endod. 2000 Dec;26(12):760-3, Favia G, Maiorano E, Orsini G, Piattelli A.
(27) . Dr. Frank Shallenberger, Second Opinion: Healing Series, V2,2015, & Second Opinion, Journal of Natural Health, 2016-2018, https://www.secondopinionnewsletter.com/Home.htm& (b)Potpourri of Healing Secrets, 2015; & The Nevada Center for Alternative and Anti-Aging Medicine; &(c) The Ozone Miracle: How you can harness the power of oxygen to keep you and your family healthy
(28) Dr. Joseph Mercola, https://www.mercola.com & Vitamin D from sunshine exposure, , https://search.mercola.com/results.aspx?q=prostate%20cancer#stq=prostate%20cancer ,
(29) 40. Dr. Bruce West, Doctors A-Z Phytoceutical Guide; & (b) Health Alert, 2017-2019, & Health Alert Store, ; &(c) )National Health and Nutrition Examination Survey, 2015 (26,000 adults); & (f) Dr. Ralph Moss, The Ultimate Guide to Cancer,; & (g) [HTML] nih.gov
(30) . (a) The Complete Guide to Reversing Alzheimers, Dr, Glen Rothfeld, & (b) 81 Natural Cures for Cancer, Alzheimers, Diabetes, etc. Dr. Rothfeld, & & (f) Dr. Rothfeld’s Secrets to a Disease- Free Life; & (g) The Best of Nutrition & Healing, Vol. XVII
110. Biomed Rep. 2016 Sep; 5(3): 283–288. Potential role of bromelain in clinical and therapeutic applications, Vidhya Rathnavelu et al
(34) Patrick Stortebecker,Associate Professor of Neurology, Karolinska Institute, Stockholm. Mercury Poisoning from Dental amalgam-A Hazard to the Human Brains, ISBN: 0-941011001-1
(35) (a)Huggins HA, Levy,TE, Uniformed Consent: the hidden dangers in dental care, 1999, Hampton Roads Publishing Company Inc; & (c) Toxic Elements Research Foundation, Colorado Springs Colorado, Survey of 1320 patients being treated for heavy metal toxicity, 2001. 800-331-2303 www. peakenergy.com
(38) S.Ziff and M.Ziff, Infertility and Birth Defects: Is
Mercury from Dental Fillings a Hidden Cause?, Bio-Probe,
Inc. ISBN: 0-941011-03-8.1987.
(41) Khera et al.,Teratogenic and genetic effects of Mercury
toxicity. The biochemistry of Mercury in the environment,
Nriagu, J.O. Ed, Amsterdam, Elsevier, 503‑18,1979; &
Teratology, 8: 293-304; & Prati M, Gornati R, et al;
A comparative study of the toxicity of mercury dichloride
and methylmercury, assayed by the Frog Embryo
Teratogenesis Assay--Xenopus(FETAX). Altern Lab Anim.
(42) Babich et al., The mediation of mutagenicity and
clastogenicity of heavy metals by physiochemical factors.
Environ Res., 1985:37;253‑286; & K. Hansen et al; A
survey of metal induced mutagenicity in vitro and in vivo,
J Amer Coll Toxicol, 1984:3;381‑430; & Rodgers JS,
Hocker JR, et al, Mercuric ion inhibition of eukaryotic
transcription factor binding to DNA. Biochem Pharmacol.
2001 Jun 15;61(12):1543-50.
(43) M. J. McCabe, University of Rochester School of
Medicine & Dentistry, 2002, Mechanisms of
Immunomodulation by Metals,
(52) Life Extension, Disease Prevention and Treatment, Fifth Edition, 2013; & Life Extension Disease Prevention and Treatment Book, 6th Edition; & (b) Life Extension Magazine, www.lifeextension.com & Life Extension Magazine, Jan 2009,July 2018, etc.
(60)Melisa Medica Foundation, http://www.melisa.org/candida.php ; & VDM Stejskal et al, "MELISA: tool for the study of metal allergy", Toxicology in Vitro, 8(5):991-1000, 1994;
(84) J.C. Veltman et al, Alterations of heme, cytochrome P-450, and steroid
metabolism by mercury in rat adrenal gland, Arch Biochem Biophys, 1986,
248(2):467-78; & Porphyrinurias Induced by Mercury and Other Metals,
B.A. Fowler, J.S. Woods, et al, Toxicological Sciences 61, 197-198 (2001),
& A.G.Riedl et al, Neurodegenerative Disease Research Center, King’s
College, UK, P450 and hemeoxygenase enzymes in the basal ganglia and
their roles in Parkinsons disease, Adv Neurol, 1999; 80:271-86;
(87) P.O.Ostman et al, Amalgam-associated oral lichenoid reactions: Clinical & histologic changes after removal of amalgam, Oral Surgery, Oral Medicine and Endodontics, 1996, 81(4):459-465; & S.H. Ibbotson et al, The relevance of amalgam replacement on oral lichenoid reactions, British Journal of Dermatology, 134(3):420-3, 1996; (270 cases)
(91) B. Lindqvist et al, "Effects of removing amalgam fillings from patients with diseases affecting the immune system", Med Sci Res 24(5): 355-356, 1996.
(94) F.Berglund, Case reports spanning 150 years on the adverse effects of dental amalgam, Bio-Probe, Inc.,Orlando,Fl,1995;ISBN 0-9410011-14-3(245 cured);
(99) M. Nylander et al, Mercury accumulation in tissues from dental staff and controls, Swedish Dental Journal, 13:235-243, 1989
(100) Dyer C.A. (2007) Heavy Metals as Endocrine-Disrupting Chemicals. In: Gore A.C. (eds) Endocrine-Disrupting Chemicals. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/1-59745-107-X_5 ; & (b) Toxic metals show evidence of carcinogenic and estrogenic properties. Epidemiology, 2019 Jan;30(1):20-28. 2019 Jan;30(1):20-28. https://pubmed.ncbi.nlm.nih.gov/30198937/ &
(c) Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines, Oxid Med Cell Longev, 2017;2017:7028583. https://pubmed.ncbi.nlm.nih.gov/29430283/
(101) [Ahmad MI, Usman A, Ahmad M. 2017. Chemosphere. 173:395-403.]; & (b) Negative impact of endocrine-disrupting compounds on human reproductive health, Reproduction, Fertility and Development 23 (3) 403-416 https://doi.org/10.1071/RD09300; & (c) Exposure to endocrine disruptors during adulthood: consequences for female fertility, Journal of Endocrinology, Vol 233, Issue 3, June 2017 https://joe.bioscientifica.com/view/journals/joe/233/3/R109
(102) Beyond Pesticides: Pesticide & Cancer Database (see study documentation for this category)- https://www.beyondpesticides.org/resources/pesticide-induced-diseases-database/cancer
(105) T.Colborn (Ed.), Chemically Induced Alterations in Functional Development, Princeton Scientific Press,1992; & Developmental Effects of Endocrine-Disrupting Chemicals", Environ Heath Perspectives, V 101, No.5, Oct 1993
(111) (a) Quig D, Doctors Data Lab,"Cysteine metabolism and metal toxicity", Altern Med Rev, 1998;3:4, p262‑270, & (b) J. de Ceaurriz et al, Role of gamma- glutamyltraspeptidase (GGC) and extracellular glutathione in dissipation of inorganic mercury",J Appl Toxicol,1994, 14(3): 201
(114) M. Aschner et al, Metallothionein induction in fetal rat brain by in utero exposure to elemental mercury vapor, Brain Research, 1997, dec 5, 778(1):222-32 & Aschner M, Rising L, Mullaney KJ. Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): studies on K+ and amino acid transport and metallothionein (MT) induction. Neurotoxicology. 1996 Spring;17(1):107-16. & T.V. O Halloran, Transition metals in control of gene expression, Science, 1993, 261(5122):715-25;
(131) Christensen MM, Ellermann Eriksen S, Mogensen SC. Influence of mercury chloride on resistance to generalized infection with herpes simplex virus type 2 in mice. Toxicology 1996, 114(1): 57-66; & S. Ellermann-Eriksen et al, "Effect of mercuric chloride on macrophage-mediated resistance mechanisms against infection", Toxicology, 93:269-297,1994; &M.M. Christensen et al, Institute of Medical Microbiology, Comparison of interaction of meHgCl2 and HgCl2 with murine macrophages, Arch Toxicol, 1993, 67(3):205-11;
(142) Ariza ME; Bijur GN; Williams MV. Lead and mercury mutagenesis: role of H2O2, superoxide dismustase, and xanthine oxidase. Environ Mol Mutagen 1998;31(4):352‑61; & M.E. Ariza et al,
Mercury mutagenesis, Biochem Mol Toxicol, 1999, 13(2):107-12;
(143) P.Boffetta et al, "Carciagenocity of mercury", Scand J Work Environ Health, 1993,19(1):1-7, & Study of workers compensated for mercury intoxication, J Occup Med, 1994,36(11):1260-4; & J Occup Med, 36(11):1260-64, 1994;
(144) .Y Zaichick et al, Trace Elements and thyroid cancer",Analyst, 120(3),1995.
(152) Langworth et al, Effects of low exposure to inorganic mercury on the human immune system, Scand J Work Environ Health, 19(6): 405-413.1993;
(159) W. Eggert-Kruse et al, Effect of heavy metals on in vitro interaction between human sperm and cervical mucus, Dtsch Med Wochenschr , 1992, 117(37):1383-9(German); E.Ernst et al, Effect of mercury on human sperm motility, Toxicol 1991, 68(6):440-4; & A.Daily et al, Declining sperm count: evidence that Young�s syndrome is associated with mercury, BMJ, 1996, 313(7048): 44;
(162) M.K.Mohamed et al, Effects of methyl mercury on testicular functions in monkeys.Toxicol, 1987, 60(1):29-36;
& N.F. Ivanitskaia, Evaluation of effect of mercury on reproductive function of animals, Gig Sanit, 1991, 12: 48-51;
(180) Pinto OF et al, J Intl Acad Prev Med, Vol 3, No.2, 1976; & Huggins HA, Proposed role of dental amalgam toxicity in leukemia and hemotopoietic dyscrasias. International J of Biosocial and Medical Research, 1989, 11:84-93; & Schimpff SC, Young WH, Greene WH, Origin of infections in acute nonlymphocytic leukemia. Annals of International Medicine 1972, 77:707-711; & Y.Kinjo et al, Cancer mortality in patients exposed to methyl mercury through fish diet, J Epidemiol, 1996, 6(3):134-8..
(181) P.W. Mathieson, Mercury: god of TH2 cells,1995, Clinical Exp Immunol.,102(2):229-30
(193) E.N.Cohen et al, Occupational disease in dentistry, Amer. Dent Assoc, 1980, 101(1): 21-31; & G. Bjorklund, Risk evaluation of the occupational environment in dental care, Tidsski Nor Laegeforen, 1991, 111(8): 948-50; & A.Ahlbom et al, :Dentists, dental nurses, and brain tumors, Br Med J, 1986, 202(6521):662.
(200) V.Nadarajah et al, Localized cellular inflammatory response to subcutaneously implanted dental mercury, J Toxicol Environ Health, 1996, 49(2):113-25; Kulacz & Levy , "The Roots of Disease” Xlibris Corporation at 1-888-795-4274 www.xlibris.com; & B.E. Haley, Dental Lab, www.altcorp.com
(201) Henningsson C, Hoffmann S, McGonigle L, Winter JS. Acute mercury poisoning mimicking pheochromocytoma in an adolescent. J Pediatr1993 Feb;122(2):252‑3
(206) R. Ma et al, Association between dental restorations and carcinoma of the tongue, European Journal of Cancer. Part B, Oral Oncology, 1995; 31B(4): 232-4.R; & P.34 Evaluation of premalignancy in oral lichenplanus and oral lichenoid lesions using immunohistochemical expression of p53 and Ki67;
R.R. Acay, S.C.O.M. Sousa and C.R. Felizzola; Oral Oncology Supplement, Volume 1, Issue 1, 2005, Page 155; & Lichenoid dysplasia and malignant transformation of oral lichen planus and oral lichenoid lesions;
P. Vescovi, M. Meleti, A. Ripasarti, et al; Oral Oncology Supplement; Volume 2, Issue 1, Supplement 1, May 2007, Page 201
(222) M. Daunderer, Handbuch der Amalgamvergiftung, Ecomed Verlag, Landsberg 1998, ISBN 3‑609‑71750‑5 (in German); & Improvement of Nerve and Immunological Damages after Amalgam Removal, Amer. J. Of ProbioticDentistry and Medicine, Jan 1991;
(225) S. Yannai et al, Transformations of inorganic mercury by candida albicans , Applied Envir Microbiology,1991, 7:245-247; & Ridley WP, Dizikes L, Cheh A, Wood JM. Recent studies on biomethylation and demethylation of toxic elements. Environ Health Perspect 1977 Aug;19:43‑6
(228) (a)A.F.Zamm, Removal of dental mercury: often an effective treatment for very sensitive patients, J Orthomolecular Med, 1990, 5(53):138-142. (22 patients), & (b)Dr. T. Rau, Paracelsus Alergy Clinic, Lustmuhle, Switzerland, Allergies: Causes, Clarification, Treatment; Explore, 8(4),1996,
(232) H.A. Huggins study funded by Adolph Coors Foundation, Denver, Study of blood chemistry changes related to the presence or absence of amalgam in 30 patients,
(233)(a) Surviving The Toxic Crisis by William R. Kellas , Andrea S. Dworkin , Comprehensive Health, 1996; & (b) Histidin as a mercurial poisoning inhibitor. Myshkin AE, Khromova VS. Biochem Biophys Res Commun. 2000 273(3):816-9;
(235) H.J.Hamre, Mercury from Dental Amalgam and Chronic Fatigue Syndrome, The CFIDS Chronicle, Fall 1994, p44-47.
(237) H.D. Foster, The calcium-selenium-mercury connection in cancer and heart disease, Hypotheses, 1997, 48(4):335-60; & Whanger PD. Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. J Trace Elem Electrolytes Health Dis. 1992 Dec;6(4):209-21.
(239) J.M.Varga et al, High incidence of cross stimulation by natural allergens of rat basophilic leukemia cells sensitized with IgE antibodies, Int Arch Allergy Immunol, 1995, 108(2):196-9; & J.H.Gainer, Activation of Rauscher leukemia virus by metals, J Natl Cancer Inst, 1973, 51(2).609-13.
(251) (a) Y.Omura et al, Heart Disease Research Foundation, NY,NY, Role of mercury in resistant infections and recovery after Hg detox with cilantro, Acupuncture & Electro-Therapeutics Research, 20(3):195-229, 1995; &(b) Mercury exposure from silver fillings, Acupuncture & Electrotherapy Res, 1996, 133- & The mercury connection to oral cancers, DAMS, www.flcv.com/olp.html
(256) D.B.Alymbaevaet al, Med Tr Prom Ekol, 6:13-15, 1995 (Russian)
(260) J.S. Woods et al, Urinary porphyrin profiles as biomarker of mercury exposure: studies on dentists, J Toxicol Environ Health, 40(2-3):1993, p235-; & Altered porphyrin metabolites as a biomarker of mercury exposure and toxicity, Physiol Pharmocol, 1996,74(2):210-15, & Canadian J Physiology and Pharmacology, Feb 1996; & M.D.Martin et al, Validity of urine samples for low-level mercury exposure assessment and relationship to porphyrin and creatinine excretion rates, J Pharmacol Exp Ther, Apr 1996;
(271) Alternative treatment of Multiple Schlerosis, Tumor or Cancer, Institute for Naturopathic Medicine 1997 (40 cases
(283) A.Ahlbom et al, Dentists, dental nurses, and brain tumors, British Medical Journal, Vol292, March 8, 1986, p262.
(285) R.C. Perlingeiro et al, Polymorphonuclear phagentosis in workers exposed to mercury vapor, Int J Immounopharmacology, 16(12):1011-7,1994; & Hum Exp Toxicol 1995, 14(3):281-6;
(296) L.Bucio et al, Uptake, cellular distribution and DNA damage produced by mercuric chloride in a human fetal hepatic cell line. Mutat Res 1999 Jan 25;423(1‑2):65‑72; & (b) Ho PI, Ortiz D, Rogers E, Shea TB. Multiple aspectsof homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNAdamage.J Neurosci Res. 2002 Dec 1;70(5):694-702; &(c) Snyder RD; Lachmann PJ; Thiol involvement in the inhibition of DNA repair by metals in mammalian cells. Source Mol Toxicol, 1989 Apr‑Jun, 2:2, 117‑28; & L.Verschaeve et al, Comparative in vitro cytogenetic studies in mercury-exposed human lymphocytes, Muta Res, 1985, 157(2-3):221-6; & L.Verschaeve, Genetic damage induced by low level mercury exposure, EnvirRes,12:306-10,1976.
(328) P. McKeever et al, Patterns of antigenic expression in human glioma cells, Crit Rev Neurobiology, 1991, 6:119-147; & Navas-Acien A, Pollan M, Gustavsson P, Plato N. Occupation, exposure to chemicals and risk of gliomas and meningiomas in Sweden. Am J Ind Med. 2002 Sep;42(3):214-27.
(330) (a) Wilkinson LJ, Waring. Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production. Toxicol In Vitro. 2002, Aug; 16(4): 481-3;; & (b) C.M. Tanner et al, Abnormal Liver Enzyme Metabolism in Parkinsons, Neurology, 1991, 41(5): Suppl 2, 89-92; & M.T.Heafield et al, “Plasma cysteine and sulphate levels in patients with Motor neurone disease, Parkinson's Disease, and Alzheimers Disease", Neurosci Lett, 1990, 110(1‑2), 216,20; & A. Pean et al, "Pathways of cysteine metabolism in MND/ALS", J neurol Sci, 1994, 124, Suppl:59‑61; & Steventon GB, et al; Xenobiotic metabolism in motor neuron disease, The Lancet, Sept 17 1988, p 644-47; & Neurology 1990, 40:1095-98.
(331) C. Gordon et al, Abnormal sulphur oxidation in systemic lupus erythrmatosus (SLE), Lancet, 1992, 339:8784,25-6; & P. Emory et al, Poor sulphoxidation in patients with rheumatoid arthitis, Ann Rheum Dis, 1992, 51:3,318-20; & Bradley H, et al, Sulfate metabolism is abnormal in patients with rheumatoid arthritis. Confirmation by in vivo biochemical findings. J Rheumatol. 1994 Jul; 21(7): 1192-6; & T.L. Perry et al, Hallevorden-Spatz Disease: cysteine accumulation and cysteine dioxygenase deficiency, Ann Neural, 1985, 18(4):482-489.
(333) A.J. Freitas et al, Effects of Hg2+ and CH3Hg+ on Ca2+ fluxes in the rat brain, Brain Research, 1996, 738(2): 257-64; & P.R.Yallapragoda et al, Inhibition of calcium transport by Hg salts in rat cerebellum and cerebral cortex, J Appl toxicol, 1996, 164(4): 325-30; & E.Chavez et al, Mitochondrial calcium release by Hg+2",J Biol Chem, 1988, 263:8, 3582-;
(369) Sterzl I, Prochazkova J, Stejskal VDM et al, Mercury and nickel allergy: risk factors in fatigue and autoimmunity. Neuroendocrinology Letters 1999; 20:221-228; & Prochazkova J, Stejskal VD, et al; The beneficial effect of amalgam replacement on health in patients with autoimmunity. Neuro Endocrinol Lett. 2004 Jun;25(3):211-8. www.nel.edu/pdf_/25_3/NEL250304A07_Prochazkova_.pdf
(395) Baranski B. Environmental Health Perspectives 1993; 101(suppl 2): 85-90; & (b)Baranski B. Effect of mercury on the sexual cycle and prenatal and postnatal development of progeny. Med Pr 1981; 32(4): 271-6; & (c) Hooper A, Mercury poisoning in Dentistry, Wisconsin Medical J, Aug 1980, vol 79; & (d) Neurophysiological and neuropsychological function in mercury-exposed dentists. The Lancet 1982; 1:1147-1150; Shapiro IM, et al; &(e) Chronic low-level mercury exposure and neuropsychological functioning. J of Clin and Exper Neuropsych 1986; 8:581-93; Uzzell BP and Oler J.
(403) "An amalgam tattoo of the soft palate: a case report with energy dispersive X-ray analysis. J Laryngol Otol, 1992 Sep, 106:9, 834-5; Mayall FG; et al; & Pierson HF. "Pharmacological perturbation of murine melanoma growth by copper chelates. Cancer Lett, 1985 Mar, 26:2, 221-33.
(404) Candida, Dysbiosis and Amalgam. J. Adv. Med. vol 9 no 2 (1996); M. E. Godfrey, & (b)
Immunity to Candida Albicans: Th1, Th2 cells and beyond. Curr Opin Microbiol 1999, 2(4):363-7; Romani L, & Alfred V. Zamm. CANDIDA ALBICANS THERAPY: Dental mercury removal, an effective adjunct. J. Orthmol. Med. v1#4 pp261-5 (1986)
(405) Stejskal J, Stejskal V. The role of metals in autoimmune diseases and the link to neuroendocrinology Neuroendocrinology Letters, 20:345‑358, 1999. www.melisa.org/knowledge/education14.html
(456) Panasiuk J, Peripheral blood lymphocyte transformation test in various skin diseases of allergic origin. PrzeglDermatol 1980;67(6):823‑9 [Article in Polish] (nickel & lupus)
(469) M.M. van Benschoten, Acupoint Energetics of Mercury Toxicity and Amalgam Removal with Case Studies, American Journal of Acupuncture, Vol. 22, No. 3, 1994, pp. 251-262; & M.M. Van Benschoten and Associates, Reseda, Calif. Clinic; http://www.mmvbs.com/
(486) Dr. Hulda Clark, The Cure for All Cancers, 1998, www.drclark.net; & Gerson Clinics,
www.gerson.org ; & The End of Cancer, Nelson�s Books, 2003; Charlotte Du Bois and John Lubecki, & Mercury detoxification, Healing Cancer Naturally, Dr. D. Klinghardt, http://www.klinghardtacademy.com; &
The Cancer Homepage, www.curezone.com/diseases/cancer/cancer_dental_risk.asp
(487) Dr. Hulda Clark, The Cure of HIV/AIDS, New Century Press, 1993; &Dr. Hulda Clark, The Cure for All Diseases, New Century Press, 2000,
(490) Prostate cancer, Ted Schettler, MD, Science Director, Science and Environmental Health Network, and Chair, Science Work Group, CHE,
(491) DOH, Agency for Toxics Substances and Disease Registry 1997; Waalkes 2000); & (c) Prostate-specific antigen levels in relation to cadmium exposure and zinc intake: results from the 2001-2002 National Health and Nutrition Examination Survey. van WijngaardenE, Singer EA, Palapattu GS. Prostate. 2008 Feb 1;68(2):122-8; & (d) Cadmium-induced cancers in animals and in humans. Huff J, et al; Int J Occup Environ Health. 2007 Apr-Jun;13(2):202-12; &(e) Trace elements and cancer risk: a review of the epidemiologic evidence. Navarro Silvera SA, Rohan TE. Cancer Causes Control. 2007 Feb;18(1):7-27
(492) Inorganic arsenic and human prostate cancer. Benbrahim-Tallaa L, Waalkes MP. Environ Health Perspect. 2008 Feb;116(2):158-64
(493) Effects of metal ions, catechins, and their interactions on prostate cancer. Yu HN, Shen SR, Yin JJ. Crit Rev Food Sci Nutr. 2007; 47(8):711-9; & (b)Inorganic arsenic and human prostate cancer. Benbrahim-Tallaa L, Waalkes MP. Environ Health Perspect. 2008 Feb;116(2):158-64
(494) (a) Cadmium-induced cancers in animals and in humans. Huff J, et al. Int J Occup Environ Health. 2007 Apr-Jun;13(2):202-12, & (b) Trace elements and cancer risk: a review of the epidemiologic evidence. Navarro Silvera SA, Rohan TE. Cancer Causes Control. 2007 Feb;18(1):7-27; & (c) Prostate-specific antigen levels in relation to cadmium exposure and zinc intake: results from the 2001-2002 National Health and Nutrition Examination Survey. van Wijngaarden E, Singer EA, Palapattu GS. Prostate. 2008 Feb 1;68(2):122-8.
(495) Soda drinkers have high pancreatic cancer risk, M. Pereira et al, Cancer Epidemiology, Biomarkers & Prevention; Feb 2010.
Prolonged ingestion of arsenic-containing drinking water is associated with an increased risk of and , and medical exposure to arsenic has been clearly associated with skin cancer in epidemiological studies. In addition, cancers of the , digestive tract, , , and and systems have been linked to arsenic exposure. ; & (c ) Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis, Int J Environ Res Public Health, 2020 Apr 29;17(9):3105.
(497) The Effects of Cadmium Toxicity, Int J Environ Res Public Health, 2020 May 26;17(11):3782.
(Epigenetic changes and development of breast, lung, prostate, nasopharynx, pancreas, and kidney cancers.) & (b) Cadmium carcinogenesis, Mutat Res. 2003 Dec 10;533(1-2):107-20 (lung, prostate, renal) & (c) Cadmium as a possible cause of bladder cancer: a review of accumulated evidence, Envir Sci Pollut Res Int. 2014 Sep;21(18):10561-73; & (d) Cadmium and renal cancer, Toxicol Appl Pharmacol. 2005 Sep 1;207(2):179-86.
(498) Cancer risk assessment for occupational exposure to chromium and nickel in welding fumes from pipeline construction, pressure container manufacturing, and shipyard building in Taiwan, J Occup Health, 2018 Nov 27;60(6):515-524. https://pubmed.ncbi.nlm.nih.gov/30122732/
(500) The mercury connection to chronic health conditions, Review (B.Windham, Ed.), http://www.myflcv.com/indexa.html, over 5,000 peer-reviewed studies cited
(501) European Prospective Investigation into Cancer and Nutrition (EPIC), American Journal of Clinical Nutrition.87(4):985-92 ; & NutraIngredients.com April 9, 2008
(503) Effects of metal ions, catechins, and their interactions on prostate cancer. Yu H, Yin JJ. Crit Rev Food Sci Nutr. 2007;47(8):711-9.
(504) Banerjee S, Manna S, Saha P, Panda CK, Das S. Black tea polyphenols suppress cell proliferation and induce apoptosis during benzo(a)pyrene-induced lung cancer. Eur J Cancer Prev. 2005, 14(3):215-21; & Banerjee S, Manna S, Mukherjee S, et al, Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhabitation of Cox-2 and induction of caspase-3 expression. Asian Pac J Cancer Prev. 2006, 7(4):661-6; & Banerjee S, Maity P, Mukherjee S et al, Black tea prevents cigarette smoke-induced apoptosis and lung damage, J Inflamm (Lond.) 2007: 43.
(505) Beltz LA, Bayer DK, Moss AL, Simet IM. Mechanisms of cancer prevention by green tea and black tea polyphenols. Anticancer Agents, Med Chem. 2006, 6(5):389-406; & Kalra N, Set K, Prasad S, et al, Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life Sci 2007 16:80(23):2137-46; & Park AM, Dong Z. Signal transduction pathways: targets for green and black tea polyphenols. J Biochem Mol Biol. 2003 Jan 31:36(1):66-77.
(506) Life Extension, Disease Prevention and Treatment, Fifth Edition, 2013; & Life Extension Disease Prevention and Treatment Book, 6th Edition; & (b) Life Extension Magazine, www.lifeextension.com & Life Extension Magazine, Jan 2009,July 2018, etc.
(530) Cancer case histories followed by doctors, www.whale.to/d/cancer.html
(531) Integrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy MetIntegrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation and Detoxification, Five Case Reports; Eliaz, I., Wilk, B. ; Forsch Komplementrmed 2007;14:358-364 http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalFreeSample&ProduktNr=224242
(539) A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production. Heyer NJ, Bittner AC, Echeverria D, Woods JS. Toxicol Lett. 2006 Feb 20;161(2):159-66. Epub 2005 Oct 7.
(543) U.S. Centers for Disease Control, National Center for Health Statistics, NHANES III study(thousands of people�s health monitored), http://www.myflcv.com/NHanes3.html
(546) Rob Edwards and Duncan Graham-Rowe. "Electrical connection" New Scientist 6 March 2002; & Dr. Mae-Wan Ho, National Radiological Protection Board (NRPB), Electromagnetic Fields Double Leukemia Risks 2002; & Richard Doll et al, Cancer Studies Unit, Oxford Univ., March 2002; & London SJ; Bowman JD; Sobel E; Thomas DC; GarabrantDH; Pearce N; Bernstein L; Peters JM. Exposure to magnetic fields among electrical workers in relation to leukemia risk in Los Angeles County. Am J Ind Med 1994 Jul;26(1):47-60; & Caplan LS; Schoenfeld ER; O'Leary ES; Leske MC. Breast cancer and electromagnetic fields--a review. Ann Epidemiol 2000 Jan;10(1):31-44;
(547) Environmental Cancer Risk: What We Can Do Now." President�s Cancer Panel Report, 2008-2009Dr. LaSalle Leffall et al, US National Institutes of Health. National cancer Institute. Division of Extramural Activities /Suzanne H. Reuben for the President�s Cancer Panel
(550) J. S. Malpas, M.D., Treatment Options for Multiple Myeloma, New England Journal of Medicine, December 12th, 2002; & Riccardi et al, British Journal of Cancer 2000;82:1254-60.
(551) Cancer Treatment, Dr. T. Simoncini, http://www.curenaturalicancro.com/
(552) International Medical Veritas Assoc., & http://www.winningcancer.com/ &
(553) Budwig Flax Oil & Cottage Cheese Cancer Treatment,
(560) Outsmart Your Cancer: Alternative Non-Toxic Treatments that Work, Tanya Pierce, MFCC, 2009
(570) Reversing Cancer: A Journey from Cancer to Cure, Dr. Gerald H. Smith, ICNR, 2006
(571) Of metalicized mouths, mycotoxicosis, and oxygen, Townsend Letter for Doctors and Patients, June, 2005 by Philip Mollica, Robert Harris www.findarticles.com/p/articles/mi_m0ISW/is_263/ai_n13784466/pg_1
(572) Dietary Supplementation with Chlorella pyrenoidosa Produces Positive Results in Patients with Cancer or Suffering from Certain Common Chronic Illnesses, R.E. Merchant and C.A. Andre, Townsend Letter for Doctors & Patients, Feb/Mar 2001; & Amalgam Detox, Klinghardt Academy of Neurobiology, 2008
(580) Cancer as a Fungal Disease, Tullio Simoncini, MS, www.cancerisafungus.com/
(581) The Prime Cause and Prevention of Cancer (1969)--Dr Otto Warburg (Nobel prize winner)
(582) Rising Ocean Temperatures, Toxic Metal Pollution Have Oysters In Hot Water, American Physiological Society, Comparative Physiology 2006, www.sciencedaily.com/releases/2006/10/061012185131.htm
Case #3: A 51 year-old male presented with stage four squamous cell carcinoma located in the right pharyngeal-tonsil space. EG underwent conventional therapy with little to no success. Clinical exam revealed cavitational osteonecroticlesion in the area of the lower right third molar. Soft tissue exam revealed swollen and inflamed pharyngeal arches, bilateral tonsilar inflammation and enlargement. Extraoral palpation revealed minor swelling of lymphatic nodes on the right side. Treatment goal was not to treat the cancer but to eradicate the infective state in the head and neck. EG was placed on a 3- month head and neck oxygen/ozone protocol developed by Dr. Mollica. This protocol was inclusive of direct and indirect infusion of 21 micograms/cc of oxygen/ozone into the afflicted areas. The afflicted areas being the osteonecrotic lesions, soft tissues, and lymphatic tissue. In addition to the oxygen/ozone therapy nutritional and drainage support was provided. Within a month after the completion of the protocol EG was given an exam which included a PET scan. No trace of the cancer or any activity associated with the lesion was found. Attributed to spontaneous remission.
(I witnessed 2 very similar “cures” while being treated for cavitation problems by Dentist in West Palm Beach, Florida-B.Windham)