Adverse
Effects of Prescription Drugs/NSAIDs/Antibiotics
1.
Studies have found pharmaceutical use to be a leading cause of hospitalizations and
the third leading cause of deaths(1).
In 1998 an extensive study published in the Journal of the American Medical
Association (JAMA) showed that 106,000 people die each year in American
hospitals from medication side effects (1). But studies also show that less
than 5% of hospitalizations and deaths due to pharmaceuticals are identified as
such so the actual total is much higher.
From 1998 through 2005,
reported serious adverse drug events to the FDA increased 2.6-fold from 34,966
to 89,842, and fatal adverse drug
events increased 2.7-fold from 5519 to 15,107. Reported serious events increased
4 times faster than the total number of outpatient prescriptions during the
period (37). Only a small percentage of such cases are reported to the FDA.
2. Tylenol/acetaminophen can cause serious or
chronic liver damage (2)(37)(38).
Tylenol/acetaminophen reduces glutathione levels, especially in elderly(20;
glutathione levels have been documented to be a marker for aging and health, as
well as chronic health conditions including degenerative eye conditions(Dr.
David Williams, Alternatives,1). Last year an FDA review estimated that there
are more than 14,000 unintentional overdoses of acetaminophen every year, with
about 100 of those cases resulting in death. In a large clinical trial taking
acetaminophen every six hours for one week, over 1/3 experienced serious liver
damage (more than tripled liver enzyme levels)(38). Studies have shown that N-acetylcysteine
(NAC) is an effective antidote for acetaminophen poisoning and is
especially effective within 8 hours of ingestion of the overdose.
3. NSAID use has been linked to “leaky gut”
and intestional damage by a large number of studies(3). Of a
group of arthritis patients with a history of NSAID use, 70% were found to have
intestinal erosion, and 25% had severe, large lesions(3b). "NSAIDs
are among the world's most frequently prescribed drugs for arthritis and
inflammatory conditions, but their use can quadruple the risk of upper
gastrointestinal problems"(3d) Ibuprofen(Advil,Midol,Motrin,Nuprin,Pamprin),
naproxen (Aleve,Naprosyn,Anaprox), and indomethacin had the worst adverse effects.
4. Newcastle Univ. researchers found that NSAIDs
are major contributors to heart problems(4).
There was evidence that NSAIDs are a major factor in
over 20% of first hospital admissions for congestive heart failure(4a). NSAIDs decrease the ability of the body to
excrete excess salt and water, resulting in fluid retention and buidup, the beginning of congestive heart failure.
In those with a history of heart problems, NSAID use increased the risk of hospital admission over 10 fold. NSAIDS have been found to sometimes cause adverse health effects including gastrointestinal, cardiovascular, and skin relations- some of which have been fata(4b).
5. NSAIDs taken by pregnant women dramatically
increase the risk of miscarriage(5). In a large
study those who took NSAIDs during pregnancy had an 80% increase in miscarraiges and even those taking baby aspirin had an
increased risk of 60%. NSAIDs interfere
with the attachment of a fertilized egg to the uterus. The Royal College of Obstetrics and Gynaecology in Britain has issued an
advisory telling women to avoid NSAID use during pregnancy.
6. NSAID use has been found to induce hypersentive reactions including asthma, respiratory
problems, and urinary problems(6). Between 8 - 20% of adult asthmatics
experience bronchospasm following ingestion of
aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs). Termed
aspirin-induced asthma, this reaction is potentially fatal. "The
prevalence of aspirin and NSAID-sensitive asthma in Australia is probably as
low as 5-10 per cent in all adults with asthma,"
7. Studies have documented an increased risk of renal
failure in some groups of elderly who use
NSAIDs(7).
8. Long term aspirin use commonly causes
gastrointestinal bleeding, and can increase your risk of heart attacks and
stroke. Long term aspirin use also
increases the risk of macula degeneration and the risk of cataracts by up to 44
%(8).
9. Antibiotic use in the first 6 months of life
has been found to be a
major cause of asthma and allergies(6,9), with an increased incidence of
over 250%. For those taking broad
spectrum antibiotics, the risk increased by from 8.9 to 11.5 times that of
those not taking antibiotics. In addition to the potential of leading to emergence
of ABx-resistant bacterial strains, Antibiotic
treatment is also responsible for 10-30% of all medication-induced adverse events(9c).
10. Gray
syndrome may be especially likely to
occur in children, who are usually more sensitive than adults to the effects of
chloramphenicol which is commonly used in the
treatment of ear infections in children. Effects include: blue tone to the
skin, changes in blood pressure or heart rate, eating problems, irregular breathing,
passage of loose green stools, or stomach bloating with or without vomiting.
11. The statin class of cholesterol-lowering drugs(Lipitor, Zocor,etc.) interrupt the body’s natural production of CoQ10 reducing blood and cellular levels(11) . CoQ10 is a necessary enzyme for heart function and other body processes. Cholestyramin(Questran,Prevalite) causes various gastrointestinal problems including constipation, bloating, inhibition of fat soluble vitamins which can lead to night blindness, bruising, increased triglyerides, osteoporosis. Numerous adverse side effect reports have implicated Lipitor and other statin drugs as a probable cause for severe neuromuscular degeneration. Some people who have been using Lipitor for as little as two months report serious muscle weakness and pain. Some who have taken it longer report much more serious symptoms, similar to Muscular Dystrophy, Parkinson's Disease, Multiple Sclerosis or ALS - Lou Gehrig's Disease - in which they are losing neuromuscular control of their bodies or losing significant muscle mass. Others have reported serious liver and kidney damage; many report significant cognitive impairment and memory loss problems. Still others have been told that they have nvCJD, the human equivalent of mad cow disease. (11a)
11.b According to Dr. Orli Etingin, vice chairman of medicine at New York-Presbyterian
Hospital, . “Statin drugs make women stupid,” There are
similar effects on men (11.ab)
11.c For healthy men, for women with or without heart disease and
for people over 70, there is little evidence, if any, that taking a statin will make a meaningful difference in how long they
live (11.c)
(11.d) A
partial listing of the potential side effects of statins: Muscle pain; Liver disease; Digestive
trouble; Kidney failure; Rhabdomyolysis (the breakdown of muscle fibers that can
result in death); Neuropathy (numbness, tingling, burning pain); Memory loss,
cognitive impairment, tinnitus, etc.
12. The FDA has notified Bristol-Myers Squibb Co. that
it must include a so-called black-box warning on its label for the
antidepressant Serzone advising patients that
life-threatening liver failure can occur with use of the drug(11). Serzone has been taken off the market in all European
countries because it has been linked to 26 deaths from liver damage.
13. Fluoroquinolone antibiotics have been found
to cause peripheral neuropathy(13). This study found that many cases are severe and
long term, with some cases affecting many organs. Of the cases followed in this study, 70%
lasted more than 3 months and 58% more than one year. Examples of fluoroquinolones causing PN are levofloxacin,
ciprofloacin,afloxacin.
14. Most cases of acute generalized exanthematic pustulosis(AGEP)
are drug induced, and get better after cesation
of drug use. amoxicillin, pristinamycin, hydroxychloroquine, ampicillin, diltiazem, co-trimoxazole, terbinafine, carbamazepine and spiramycin have most cases.
15. Merck
deliberately mislead doctors and public about safety
of Vioxx.
After a company study in
March 2000, known as VIGOR, reported increased heart attack risks, Merck
directed its sales force to show physicians a "cardiovascular card"
that made it appear Vioxx could be eight to 11 times
safer than other anti-inflammatory drugs. The card omitted any reference to
VIGOR and was based on data the FDA considered to be inappropriate for a safety
analysis.
After an FDA advisory committee agreed in a 2001 vote that physicians should be
informed of the risks found in the VIGOR study, Merck sent a bulletin to its
sales force that advised: "Do not initiate discussions of the FDA
Arthritis Committee ... or the results of the ... VIGOR study." If
physicians asked about the study, Merck representatives were told to respond,
"I cannot discuss the study with you."
After the New York Times reported on the cardiovascular danger of Vioxx in May 2001, Merck instructed its field staff to tell
physicians that patients on other anti- inflammatory medications were eight
times more likely to die from cardiovascular causes than patients on Vioxx.
After extensive negotiations with the FDA, Merck agreed to a label change for Vioxx in April 2002 that mentioned the cardiovascular risks
found in the VIGOR study, but it included a statement that the significance of
the findings was "unknown." The committee said Merck then instructed
its sales force to emphasize the uncertainty of the VIGOR study to counter
physician's concerns.
For Vioxx®, the
risk of blood clots was approximately 34 per cent higher than the risk in
comparable patients not treated with Vioxx®. On
average, blood clots appeared in 0.3 per cent of Vioxx®
users(15b).
16. Data from the ADAPT trial indicated an apparent
increase in cardiovascular and cerebrovascular events
among the participants taking naproxen(Aleve) when
compared with those on placebo.(16)
17.
Inositol supplementation was found to be more
effective than the SSRI fluvoxamine for panic
disorder, while also having less adverse health effects(17a).
Poor nutrition and lack of exercise have
been found to be major factors in neurological conditions such as depression(17b). Regular
exercise, meditation, and nutritional supplements including 5-HTP, SAMe, Tryptophan, vitamin B12, multi B vitamins, magnesium,
St. John’s Wort, DHEA, Rodelia
rosea, DMAE, choline, etc.
and testosterone in older men with low testosterone have been found to be
effective in preventing and treating depression(17b). Double blind studies have found 5-HTP to be
as effective as prescription antidepressives
including SSRIs at treating conditions such as depression(17c).
Mercury from dental amalgam fillings
and toxic metals have also been found to be common causes of depression and
mood disorders, with recover or significant improvement common after amalgam
replacement and detoxification (17c).
18. Bruxism(tooth grinding)
and headaches have been found to be
associated with the use of certain medications, such as L-dopa (used in
Parkinson's Disease) and with some of
the so-called "SSRI" antidepressants. These include Prozac, Paxil,
Zoloft, Celexa, and Luvox.
(18)
19. SSRIs cause hyperprolactinimemia
which results in erectile disfunction, increased
breast cancer, autoimmune conditions such as lupus, etc. (19)
. Proscar(finasteride) has been found to
increase significantly the risk of breast cancer in men as well as breast enlargement (gynecomastia) (19a)
20.
Children
and young people treated with SSRI or SNRI more frequently exhibit suicidal
thoughts and suicidal behavior as well as hostile behavior than comparable
patients treated with a placebo(20).
21.
Preliminary
results of a Danish register study1 show an increased occurrence of
malformation in children born by mothers who had used an antidepressant of the
type SSRI during the early pregnancy (1 st
trimester).
22. Moms' Antidepressants Affect Newborns . A study, headed by Dr. Rachel Levinson-Castiel of the Children's Medical Center in Petah Tiqwa,
found that nearly one in three infants born to women taking anti-depressants
showed signs of withdrawal. Symptoms
such as high-pitched crying, tremors, gastrointestinal problems and disturbed
sleep showed up in the first 48 hours after birth and were more pronounced in
babies whose mothers had been taking higher doses. The risk was highest among
those exposed to 27 mg or more. Thirty
percent of the 60 newborns exposed before birth to selective serotonin reuptake
inhibitors had withdrawal symptoms and the symptoms were classified as severe
in 13 percent. Symptoms usually did not
peak until after the first day of life but the long-term effects are not known,
the researchers said(24)
23. The makers of antidepressants like Prozac and Paxil never published the results of about a third of the drug trials that they conducted to win government approval, misleading doctors and consumers about the drugs’ true effectiveness, a new analysis has found. : when all data is considered the drugs outperform placebos, but by a modest margin, concludes the new report.
24.
It has
been detected that there is an increased risk of blood clots by use of the
selective COX-2 inhibitors (celecoxib, etoricoxib, lumiracoxib, paracoxib).
25. 2 osteoporosis drugs, Reclast, a drug made by Novartis
AG and Fosamax by Merck &
Co, were found to sometimes cause irregular heart rhythms.
26. Antibiotics are the leading cause of drug related adverse effects and deaths (26).
27. Certain antibiotics, such as the fluoroquinolones,
the class of antibiotics that includes the name-brands and generic brands of Levaquin™, Cipro™, Tequin™, and Avelox™, actually
are known to trigger a type of virus called bacteriophages
(viruses that can infect bacteria), to change the genetic sequencing of the
bacteria, causing the bacterium they have infected to start producing toxins.
These viruses can act as genetic delivery vans, invading bacteria, such as
spirochetes, and often lying dormant until activated by a change in the host
(your body) environment. Once activated, these viruses insert their
toxin-generating genes into the bacterial chromosomes. These viruses can turn
basically harmless bacterium into killers through this genetic sequencing of
toxins (27).
28. Based on
five years of data on 3,876 heart bypass patients from around the world, the
death rate among the 1,072 patients given Bayer AG's anti-bleeding drug aprotinin (Trasylol) was nearly
21 percent, two-thirds higher than the mortality rate among surgery patients
not given anti-bleeding drugs.
Bayer
failed to reveal to U.S. regulators the results of a large study suggesting
that a widely used heart-surgery medicine might increase the risks of death and
stroke, the U.S. Food and Drug Administration has announced. (28)
29. In clinical trials by Merck, the cholesterol
lowering drugs Zetia and Vytorin
were found to not be effective at preventing heart attacks, and in fact caused
fatty plaques to grow almost twice as fast as in the control. Fatty plaques are
a known risk factor for heart attacks and strokes(29).
30. Liberty Link(Bayer)
genetically modified corn has been found to cause adverse health effects to
test animals and people (28).
31. A new study gave
28 of the men a one-year course of finasteride (Proscar(r)), the standard drug for benign prostate
problems. The other 25 were given nothing. When the year was up, researchers
gave each man a second biopsy. Nearly 30% of the men taking Proscar(r) developed prostate Tumors. Yet tumors were found in only one of the 25 men
taking nothing.
32. Although studies have shown a connection between Singulair use to suicidal
thoughts, Merck does not widely publicize this, as they are supposed to.
33. Two creams used to treat eczema, Elidel and Protopic,
will also soon carry the FDA's strongest "black box" warning on their
packaging to alert doctors and patients to healh risks including cancer. The
warning advises doctors to prescribe short-term use of Elidel and Protopic only
after other available eczema treatments have failed in adults and children over
the age of 2. The FDA's Pediatric Advisory Committee reviewed research in
animals that of skin cancer and non-Hodgkin's lymphoma. In those studies, the risk of
cancer increased as the dose of the drugs increased. Research presented at the meeting also linked
Elidel and Protopic to about 25 cases of cancer in adults and children who used
the drugs. The FDA has also received
reports of serious adverse events in children under the age of 2 who were
prescribed the drugs.
34. An independent
analysis of thousands of older people with diabetes found that those treated with the
widely used drug Avandia had significantly elevated
risks of heart attack and death. “Our study suggests that at least in this
high-risk population, the harms of the drug may outweigh the benefits,” Confidential government reports say that about 500
heart attacks and 300 cases of heart failure would be averted every month if
patients switched away from Avandia.
(34b) One
report, by Dr. David Graham and Dr. Kate Gelperin of
the FDA, argued that Avandia should be withdrawn from
the market. (34b) A study was published in the New England Journal of
Medicine (NEJM) that linked Avandia to a 43
percent increased risk of heart attack and a 64 percent higher risk of
cardiovascular death than patients treated with other methods(34ad). A bipartisan multiyear Senate
investigation found
the sharply criticizes GlaxoSmithKline, saying it failed to warn patients years
earlier that Avandia was potentially deadly. The
study concluded that rosiglitazone causes increased
weight gain and edema, and
has a hazard ratio greater than unity. (34c)
35. computed tomography scans, or CT, are a health risk for radiation. each scan gives the patient a far higher dose of radiation
than a conventional X-ray would. Unfortunately, even many doctors have no idea
how much radiation a CT scan delivers. the researchers
suggest, as many as 2 percent of all cancers in the United States may be
because of radiation from CT scans performed today.
36. An experimental anticlotting drug from Eli Lilly, prasugrel, quadrupled the
risk of fatal bleeding though other benefits were found compared to Plavix.
37. The Rx
painkillers oxycodone and fentanyl
caused at least 9000 deaths between 1998 and 2005. The
antipsychotic Clozapine caused at least 3277 deaths
between 1998 and 2005.
The antipsychotic
medication risperidone (Risperdal) was
responsible for at least 1093 deaths between 1998 and 2005. interferon-beta, a drug that helps regulate the immune
system; and two immune-affecting drugs, Infliximab and Etanercept, were each responsible for over 1000 deaths
between 1998 and 2005.
38. Sodium benzoate with
vit C produces benzene, which is toxic and
carcinogenic. Found in most soft drinks, juices, pickles, salad dressings,
jams, etc. FDA tests have found levels
of benzene in some soft drinks 16 times the health standard for drinking
water. (38)
39. Seroquel, a drug used for
schizophrenia, caused weight gain, hyperglycemia (increased blood sugar), and
diabetes in thousands of patients. A Washington
Post analysis found that 4 out of 5 patients quit taking Seroquel in less than a year. A large study found that Seroquel
was no more effective than other options.
40. Drug-coated stents may
hinder
the heart's natural ability to form tiny collateral blood vessels that can
salvage heart muscle by rerouting the blood supply, according to at least 3 studies(40). Because drug-eluting stents reduce arterial
tissue growth, they can increase the risks of blood clots. Nearly a third of
patients who had drug-coated stents implanted in vein grafts to improve
coronary blood flow died within 32 months, Dutch cardiologists report(40b). According to the American Heart Assoc., invasive
heart treatments supply 45% of large hospital revenues.
41. Patients getting angioplasty after heart attacks had more repeat attacks than otherwise. Angioplasty works no better than standard heart medication (drugs to control blood pressure, lower cholesterol, and prevent blood clots) in preventing heart attack, stroke, and hospitalization in patients with stable coronary artery disease(41b).
42. People
who drink two or more sweetened soft drinks a week have a much higher (87%) risk
of pancreatic cancer. The high levels of sugar in soft drinks may be increasing
the level of insulin in the body, which the authors think contributes to
pancreatic cancer cell growth(42).
43. Excess
zinc exposure from sources such as GSK Superpolygrip
found to cause many neurological conditions including paresthesias,
desesthesias, and conditions related to copper
deficiency such as anemia, neuropathy, etc.
Some of the effects are similar to those of MS, Demyelinating
Syndrome, Chronic Inflammatory Demyelinating
Polyneuropathy (CIDP).
44. Depakene/Depakote (valproate acid) is a deadly drug that robs many nutrients
and damages the liver. Carbamazepine (Tegretol) is even
more dangerous. It also drains biotin, folic acid, vitamins D and E, carnitine, sodium, and may contribute to allergies by
decreasing IgG2. Ammonia is increased while alpha-ketoglutarate
is reduced. GI upset is common. While one should normally drink lots of water,
this drug may make you water intoxicated!
Thyroid testing on this drug is unreliable(44)
45. The ADHD drugs Ritalin and Adderall
have been found to cause cardiovascular problems in some, with hundreds of
deaths reported. Health
Canada has ordered ADDERALL XR to be taken off the market in that country,
primarily because of deaths that occurred in the U.S., In psychotic children Ritalin may worsen symptoms of behavior disturbance
and thought disorder. Abuse of this drug can lead to tolerance and psychic
dependence with varying degrees of abnormal behavior, severe depression can
occur with withdrawal(45c) Growth
retardation (suppression of height and/or weight gain) has been reported in
children using this drug. Long-term therapy (greater than 24 months) is
especially dangerous.(45c)
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www.nytimes.com/2007/12/12/business/12drug.html?_r=1&oref=slogin
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increases risk of stroke and heart failure for seniors, D.J. Graham et al, JAMA,
June 2010
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Ten Lies About Health Your Doctor Taught You
Date: 5/5/05 Author: Mike Adams Source: NewsTarget.com
Ten Lies About Health Your
Doctor Taught You
Lie #1: Prescription drugs will make you healthier.
Truth #1: Prescription drugs only mask symptoms. They do nothing to correct the
underlying biochemical causes of disease. Simultaneously, most prescription
drugs cause nutritional deficiencies which lead to further progression of
chronic disease.
See http://www.newstarget.com/001352.html
Lie #2: You should actively treat the swelling of sprains, strains and other
injuries.
Truth #2: Swelling is your body's natural strategy for enhancing the flow of
blood and nutrients to the injured area. If drugs or hormones are used to
prevent swelling, the injured tissues won't heal correctly, greatly increasing
the likelihood of repeat injuries to the same area.
Lie #3: Mammograms prevent cancer.
Truth #3: Mammograms actually cause cancer. They dose the breast tissues with
harmful radiation. Even when they spot breast cancer tumors, they aren't
"preventing" breast cancer; they're merely detecting breast cancer.
True prevention requires changes in food choice and lifestyle, not the use of
imaging technology. See http://www.newstarget.com/000895.html
Lie #4: Vitamins give you "expensive urine."
Truth #4: The most expensive urine in the world is created by taking multiple
overpriced prescription drugs, not vitamins. With more than 40% of the U.S.
population now on prescription drugs, the drug content in human urine is now so
high that trace amounts of antidepressant drugs can be found in public water
supplies. Compared to drugs, vitamins are cheap prevention.
See http://www.newstarget.com/001891.html
Lie #5: The sun will give you cancer.
Truth #5: The sun will prevent cancer due to the creation of vitamin D by the
skin. Most Americans (and Canadians and Europeans, for that matter) are
deficient in vitamin D. As a result, tumor cell growth in the breast and
prostate is unregulated. Sensible exposure to natural sunlight generates
cancer-preventing vitamin D... at no charge! Sunburns are actually caused by
nutritional deficiencies (lack of antioxidants in the skin), not by sensible
exposure to sunlight.
See http://www.newstarget.com/Vitamin_D.html
Lie #6: CT scans (CAT scans) are perfectly safe.
Truth #6: CT scans expose patients to 1000 times the radiation of chest X-rays.
Repeated exposure to CT scans raises a patient's cumulative radiation to levels
experienced by many hydrogen bomb victims in Hiroshima. In addition, rigorous
studies have concluded that CT scans offer no medical benefit whatsoever. See http://www.newstarget.com/004060.html
Lie #7: The U.S. health care system is the best in the world.
Truth #7: The health of U.S. citizens is actually the worst of any
industrialized nation. We pay double, triple, and even quadruple the price for
prescription drugs as any other country. We also have the highest rates of
obesity, Alzheimer's, cancer and diabetes, plus the highest health insurance
costs in the world. The U.S. health care system ("sick care system")
is so bad that people are fleeing the country to seek medical services in Asia.
It's a trend called "medical tourism," and it's flourishing.
See http://www.newstarget.com/007097.html
Lie #8: All surgical procedures have been proven safe and effective.
Truth #8: There is currently NO requirement whatsoever that
surgical procedures must be either safe or effective in order to be
practiced. Hundreds of thousands of medically unnecessary surgical procedures
are performed each year in the U.S. alone, including hysterectomies and
prostate cancer surgeries.
See http://www.newstarget.com/002608.html
Lie #9: You can get all the nutrition you need from three balanced meals a day.
Truth #9: Today's foods are nutrient depleted, and they come from depleted
soils. Processed and manufactured foods would have to be eaten at the rate of
10,000 calories a day just to meet minimum RDA requirements for basic nutrition
(see related ebook on nutrition). The only way to get
adequate nutrition is to supplement with superfoods
or whole food concentrates (vitamins, whole food powders, supplement capsules,
etc.) along with eating healthy meals. Organizations like the AHA, however,
insist that nutrient supplementation is actually bad for your health.
See http://www.newstarget.com/001587.html
Lie #10: All these lab tests are for your own good.
Truth #10: At least half of all diagnostic tests ordered by doctors are
medically unnecessary. They're often conducted merely to generate revenues for
the hospital or medical group that owns the doctor's clinic. Some doctors are
actually required to generate a certain dollar amount of lab test revenues in
order to keep their jobs.
Overview:
Ten Lies About Health Your Doctor Taught You
Source: http://www.newstarget.com/007348.html
K.
Johnson et al, Institute of Medicine, National Academy of
Sciences, July
2006
At least 1.5 million
Americans are injured or killed every year by medication errors at a direct
cost of billions of dollars. Approx. 98,000 people are killed each year as a
result of medical errors, 7,000 due to medication errors.
Please take special note of yesterdays post
regarding Depakene/Depakote
(valproate acid). This is a deadly drug that robs
many nutrients and damages the liver.
Carbamazepine (Tegretol) is
even more dangerous. It also drains biotin, folic acid, vitamins D and E, carnitine, sodium, and may contribute to allergies by
decreasing IgG2. Ammonia is increased while alpha-ketoglutarate
is reduced. GI upset is common. While one should normally drink lots of water,
this drug may make you water intoxicated!
Thyroid testing on this drug is unreliable (more than usual, that is)